AMPK-mediated regulation of endogenous cholesterol synthesis does not affect atherosclerosis in a murine Pcsk9-AAV model.

Autor: Smith TKT; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Ghorbani P; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., LeBlond ND; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Nunes JRC; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., O'Dwyer C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Ambursley N; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Fong-McMaster C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Minarrieta L; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Burkovsky LA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., El-Hakim R; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Trzaskalski NA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Locatelli CAA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Stotts C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Pember C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Rayner KJ; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Kemp BE; Protein Chemistry and Metabolism, St. Vincent's Institute of Medical Research, Fitzroy, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia., Loh K; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia., Harper ME; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Mulvihill EE; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., St-Pierre J; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Fullerton MD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Centre for Catalysis Research and Innovation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada. Electronic address: morgan.fullerton@uottawa.ca.

Publikováno v: Atherosclerosis [Atherosclerosis] 2024 Oct; Vol. 397, pp. 117608. Date of Electronic Publication: 2024 Jun 03.

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection.

Autor: Ghorbani P; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Kim SY; Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California, United States of America., Smith TKT; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Minarrieta L; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Robert-Gostlin V; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Kilgour MK; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Ilijevska M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Alecu I; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Snider SA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Margison KD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Nunes JRC; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Woo D; Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California, United States of America., Pember C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., O'Dwyer C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Ouellette J; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Kotchetkov P; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., St-Pierre J; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Bennett SAL; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada.; University of Ottawa Brain and Mind Institute, University of Ottawa, Ottawa, Ontario, Canada., Lacoste B; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; University of Ottawa Brain and Mind Institute, University of Ottawa, Ottawa, Ontario, Canada., Blais A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.; University of Ottawa Brain and Mind Institute, University of Ottawa, Ottawa, Ontario, Canada.; Éric Poulin Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., Nair MG; Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California, United States of America., Fullerton MD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Sep 25; Vol. 19 (9), pp. e1011658. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).

Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1.

Autor: Salt IP; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Nunes JRC; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Fullerton MD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2021 Apr 23; Vol. 117 (5), pp. 1233-1234.

Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis.

Autor: LeBlond ND; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Ottawa, ON K1H 8M5, Canada.; Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada., Nunes JRC; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Ottawa, ON K1H 8M5, Canada.; Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada., Smith TKT; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Ottawa, ON K1H 8M5, Canada.; Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada., O'Dwyer C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Ottawa, ON K1H 8M5, Canada.; Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada., Robichaud S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada., Gadde S; Centre for Infection, Immunity and Inflammation, Ottawa, ON K1H 8M5, Canada.; Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Côté M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Ottawa, ON K1H 8M5, Canada.; Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada., Kemp BE; St. Vincent's Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Melbourne, VIC 3065, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC 3065, Australia., Ouimet M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada., Fullerton MD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, Ottawa, ON K1H 8M5, Canada.; Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 27; Vol. 21 (23). Date of Electronic Publication: 2020 Nov 27.

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.

Autor: Loh K; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia., Tam S; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia., Murray-Segal L; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia., Huynh K; Baker Heart and Diabetes Institute Melbourne Australia., Meikle PJ; Baker Heart and Diabetes Institute Melbourne Australia., Scott JW; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia.; Mary MacKillop Institute for Health Research Australian Catholic University Fitzroy Australia.; The Florey Institute of Neuroscience and Mental Health Parville Australia., van Denderen B; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia., Chen Z; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia., Steel R; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia., LeBlond ND; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Burkovsky LA; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., O'Dwyer C; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Nunes JRC; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Steinberg GR; Division of Endocrinology and Metabolism, Department of Medicine and Department of Biochemistry and Biomedical Sciences McMaster University Hamilton Canada., Fullerton MD; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Galic S; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia., Kemp BE; St. Vincent's Institute of Medical Research and Department of Medicine University of Melbourne Fitzroy Australia.; Mary MacKillop Institute for Health Research Australian Catholic University Fitzroy Australia.

Publikováno v: Hepatology communications [Hepatol Commun] 2018 Nov 12; Vol. 3 (1), pp. 84-98. Date of Electronic Publication: 2018 Nov 12 (Print Publication: 2019).