Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Nukhet Aykin-Burns"'
Autor:
Kimberly K. Richardson, Gareeballah Osman Adam, Wen Ling, Aaron Warren, Adriana Marques-Carvalho, Jeff D. Thostenson, Kimberly Krager, Nukhet Aykin-Burns, Stephanie D. Byrum, Maria Almeida, Ha-Neui Kim
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102012- (2024)
Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive. Methods:
Externí odkaz:
https://doaj.org/article/b1c37c9a2bd346bf8f32edeea3efc5b8
Autor:
Mitchell R. McGill, Yihong Kaufmann, Francesca V. LoBianco, Mary A. Schleiff, Nukhet Aykin-Burns, Grover P. Miller
Publikováno v:
Livers, Vol 3, Iss 2, Pp 310-321 (2023)
Tyrosine kinase inhibitors (TKIs) are increasingly popular drugs used to treat more than a dozen different diseases including some forms of cancer. Despite having fewer adverse effects than traditional chemotherapies, they are not without risks. Live
Externí odkaz:
https://doaj.org/article/cb87a53173f0461394b2908ac863a3c6
Autor:
Hee Jo, Eun, Eun Moon, Ji, Han Chang, Moon, Jin Lim, Ye, Hyun Park, Jung, Hee Lee, Suk, Rae Cho, Young, Cho, Art E, Pil Pack, Seung, Kim, Hyeon-Wee, Crowley, Liana, Le, Brandy, Nukhet, Aykin-Burns, Chen, Yinfeng, Zhong, Yihang, Zhao, Jiangchao, Li, Ying, Cha, Hanvit, Hoon Pan, Jeong, Kyeom Kim, Jae, Hyup Lee, Jin
Publikováno v:
In Journal of Advanced Research April 2023 46:17-29
Autor:
Stephen A. Shrum, Ujwani Nukala, Shivangi Shrimali, Edith Nathalie Pineda, Kimberly J. Krager, Shraddha Thakkar, Darin E. Jones, Rupak Pathak, Philip J. Breen, Nukhet Aykin-Burns, Cesar M. Compadre
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 1987 (2023)
Tocotrienols have powerful radioprotective properties in multiple organ systems and are promising candidates for development as clinically effective radiation countermeasures. To facilitate their development as clinical radiation countermeasures, it
Externí odkaz:
https://doaj.org/article/025774aeb31a47a8886e67dfde8f0adf
Autor:
Francesca V. LoBianco, Kimberly J. Krager, Erica Johnson, Christopher O. Godwin, Antino R. Allen, Peter A. Crooks, Cesar M. Compadre, Michael J. Borrelli, Nukhet Aykin-Burns
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Hepatocellular carcinoma (HCC) is both a devastating and common disease. Every year in the United States, about 24,500 men and 10,000 women are diagnosed with HCC, and more than half of those diagnosed patients die from this disease. Thus far, conven
Externí odkaz:
https://doaj.org/article/d6d60f2b0ea64b4a892940f526bb9c89
Autor:
Shivangi Shrimali, Awantika Singh, Rajeshkumar Manian, Shraddha Thakkar, Darin E. Jones, Nukhet Aykin-Burns, Philip Breen, Cesar M. Compadre
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 136-137 (2023)
OBJECTIVES/GOALS: We have designed an analogue of the Vitamin E tocotrienols called tocoflexol, which improves their pharmacokinetic limitations to make it an effective radiation medical countermeasure. Our goal is to demonstrate that tocoflexol is a
Externí odkaz:
https://doaj.org/article/201ed12be68747c2b703bbceb902db82
Autor:
Bhaba K Das, Lei Wang, Toshifumi Fujiwara, Jian Zhou, Nukhet Aykin-Burns, Kimberly J Krager, Renny Lan, Samuel G Mackintosh, Ricky Edmondson, Michael L Jennings, Xiaofang Wang, Jian Q Feng, Tomasa Barrientos, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao
Publikováno v:
eLife, Vol 11 (2022)
Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation and bone-resorbing activities. Transferrin receptor 1 (Tfr1) mediates cellular iron uptake through endocytosis
Externí odkaz:
https://doaj.org/article/e7aaa3c107a7445d8a2e1c1f94e4180c
Autor:
J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M. Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N. Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V. Costes, Gustavo Gastão Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M. Bowman, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti, Shannon M. Wallet, Robert Maile, Jason R. Mock, Jose L. Torres-Castillo, Miriya K. Love, Will Lovell, Colleen Rice, Olivia Mitchem, Dominique Burgess, Jessica Suggs, Jordan Jacobs
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109839- (2021)
Summary: MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determ
Externí odkaz:
https://doaj.org/article/86972322eb3c4fa78fa77d4ae3931268
Autor:
Wen Ling, Kimberly Krager, Kimberly K. Richardson, Aaron D. Warren, Filipa Ponte, Nukhet Aykin-Burns, Stavros C. Manolagas, Maria Almeida, Ha-Neui Kim
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Altered mitochondria activity in osteoblasts and osteoclasts has been implicated in the loss of bone mass associated with aging and estrogen deficiency — the 2 most common causes of osteoporosis. However, the mechanisms that control mitochondrial m
Externí odkaz:
https://doaj.org/article/d5d541c4793546f1b079b8934ee93010
Autor:
Vijayalakshmi Sridharan, Kristin A Johnson, Reid D Landes, Maohua Cao, Preeti Singh, Gail Wagoner, Abdallah Hayar, Emily D Sprick, Kayla A Eveld, Anusha Bhattacharyya, Kimberly J Krager, Nukhet Aykin-Burns, Hartmut Weiler, Jose A Fernández, John H Griffin, Marjan Boerma
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252142 (2021)
Accidental exposure to ionizing radiation may lead to delayed effects of acute radiation exposure (DEARE) in many organ systems. Activated protein C (APC) is a known mitigator of the acute radiation syndrome. To examine the role of APC in DEARE, we u
Externí odkaz:
https://doaj.org/article/50e75a3eea9247aa991916479ae21a30