The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.

Autor: Wildenberg ME; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., Koelink PJ; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands., Diederen K; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands., Te Velde AA; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., Wolfkamp SC; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., Nuij VJ; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands., Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands., Nobis M; Beatson Institute for Cancer Research, Bearsden, Glasgow, UK., Sansom OJ; Beatson Institute for Cancer Research, Bearsden, Glasgow, UK., Anderson KI; Beatson Institute for Cancer Research, Bearsden, Glasgow, UK., van der Woude CJ; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands., D'Haens GR; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands., van den Brink GR; Tytgat Institute for Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2017 Mar; Vol. 10 (2), pp. 352-360. Date of Electronic Publication: 2016 Jul 20.

Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease.

Autor: Parikh K; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Deusinglaan 1, NL-9713 AV Groningen, the Netherlands., Zhou L, Somasundaram R, Fuhler GM, Deuring JJ, Blokzijl T, Regeling A, Kuipers EJ, Weersma RK, Nuij VJ, Alves M, Vogelaar L, Visser L, de Haar C, Krishnadath KK, van der Woude CJ, Dijkstra G, Faber KN, Peppelenbosch MP

Publikováno v: Science translational medicine [Sci Transl Med] 2014 Apr 23; Vol. 6 (233), pp. 233ra53.

Phenotype of inflammatory bowel disease at diagnosis in the Netherlands: a population-based inception cohort study (the Delta Cohort).

Autor: Nuij VJ; Department of Gastroenterology and Hepatology, ErasmusMC, Rotterdam, The Netherlands. v.nuij@erasmusmc.nl, Zelinkova Z, Rijk MC, Beukers R, Ouwendijk RJ, Quispel R, van Tilburg AJ, Tang TJ, Smalbraak H, Bruin KF, Lindenburg F, Peyrin-Biroulet L, van der Woude CJ

Publikováno v: Inflammatory bowel diseases [Inflamm Bowel Dis] 2013 Sep; Vol. 19 (10), pp. 2215-22.

Majority of patients with inflammatory bowel disease in clinical remission have mucosal inflammation.

Autor: Baars JE; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands. j.baars@erasmusmc.nl, Nuij VJ, Oldenburg B, Kuipers EJ, van der Woude CJ

Publikováno v: Inflammatory bowel diseases [Inflamm Bowel Dis] 2012 Sep; Vol. 18 (9), pp. 1634-40. Date of Electronic Publication: 2011 Nov 08.