Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Nuggehally R. Srinivas"'
Autor:
Krishnarup Ghoshdastidar, Hoshang Patel, Hitesh Bhayani, Ankit Patel, Kinjal Thakkar, Dinesh Patel, Manoranjan Sharma, Jaideep Singh, Jogeswar Mohapatra, Abhijit Chatterjee, Dipam Patel, Rajesh Bahekar, Rajiv Sharma, Lakshmikant Gupta, Nirmal Patel, Poonam Giri, Nuggehally R. Srinivas, Mukul Jain, Debdutta Bandyopadhyay, Pankaj R. Patel, Ranjit C. Desai
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Bruton's tyrosine kinase (BTK) plays a central and pivotal role in controlling the pathways involved in the pathobiology of cancer, rheumatoid arthritis (RA), and other autoimmune disorders. ZYBT1 is a potent, irreversible, specific BTK inhi
Externí odkaz:
https://doaj.org/article/426ccabb23744fc0aceb0a7d29b505f0
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21, Iss 1 (2018)
Number of drugs with different mechanisms of actions is undergoing clinical trials for non-alcoholic steatohepatitis (NASH). Given the complexity of the disease with respect to pathophysiology in the liver and associated changes in the renal function
Externí odkaz:
https://doaj.org/article/65ffe87523c54eeb9a75c01b415b0840
Autor:
Mohd Zainuddin, Umesh Todmal, Narayanan Balaji, Ramesh Mullangi, Nuggehally R. Srinivas, Bhavesh Babulal Gabani, Vinay Kiran, Saibabu Polina, Neeraj Kumar Saini, Suresh P. Sulochana
Publikováno v:
Drug Metabolism Letters. 14:54-65
Background: Darolutamide is recently approved for the treatment of non-metastatic castrate resistance prostate cancer. Hitherto, no stereoselective pharmacokinetic data have been published pertaining to darolutamide and its diastereomers in animals o
Autor:
R. Jayachandra Babu, Peter Panizzi, Robert D. Arnold, Li Chen, Nuggehally R. Srinivas, Mallesh Kurakula, Amit K. Tiwari, Ranjeet P Dash
Publikováno v:
Critical Reviews™ in Therapeutic Drug Carrier Systems. 38:1-38
Melanoma is one of the most aggressive forms of cancer with limited treatment options available. Successful treatment involves a combination of surgical resection of the tumor; chemotherapy and immunotherapy. Given their complex nature, the rapid dev
Whole blood or plasma: what is the ideal matrix for pharmacokinetic-driven drug candidate selection?
Autor:
Jennifer A. Thomas, Vijayabhaskar Veeravalli, Ranjeet P Dash, Nirali Mehta, Clint Rosenfeld, Nuggehally R. Srinivas
Publikováno v:
Future Medicinal Chemistry. 13:157-171
In the present era of drug development, quantification of drug concentrations following pharmacokinetic studies has preferentially been performed using plasma as a matrix rather than whole blood. However, it is critical to realize the difference betw
Autor:
Jennifer A. Thomas, R. Jayachandra Babu, Lakshmi Mohan Vamsi Madgula, Vijayabhaskar Veeravalli, Ranjeet Prasad Dash, Nuggehally R. Srinivas
Publikováno v:
Drug Safety. 43:711-725
The introduction of novel, small-molecule Janus kinase inhibitors namely tofacitinib, baricitinib and upadacitinib has provided an alternative treatment option for patients with rheumatoid arthritis outside of traditional drugs and expensive biologic
Autor:
Namrata Prajapati, Poonam Giri, Prashant Delvadia, Shyamkumar Giri, Nuggehally R. Srinivas, Nirmal Patel, Vipul Joshi, Mukul R. Jain, Meera K. Ladani
Publikováno v:
Xenobiotica. 50:815-821
Recent approvals of beta-lactamase inhibitor (BLI) drug in combination with cephalosporins/penems have provided the right impetus for novel BLIs. One important research question, hitherto not addressed, is pertaining to the relevance of preclinical p
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 18, Iss 3 (2015)
Purpose: The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous and oral pharmacokinetics of six dipeptidy peptidase-IV (DPP-IV) inhibitors viz. ABT-279, ABT-341, alogliptin, carmeglip
Externí odkaz:
https://doaj.org/article/5c77592ad2354919b0695b3df1032d2d
Autor:
Nuggehally R. Srinivas
Publikováno v:
European Journal of Clinical Pharmacology. 76:469-471
Publikováno v:
Drug Development and Industrial Pharmacy. 45:1421-1429
Sorbitol is a popular sugar alcohol which has been used as an excipient in formulations of various drugs. Although from a safety perspective the presence of sorbitol in drug formulations does not raise a concern, reports have emerged and these sugges