Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nufar Edinger"'
Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF.
Autor:
Nufar Edinger, Mario Lebendiker, Shoshana Klein, Maya Zigler, Yael Langut, Alexander Levitzki
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162321 (2016)
Selective delivery of drugs to tumor cells can increase potency and reduce toxicity. In this study, we describe a novel recombinant chimeric protein, dsRBEC, which can bind polyIC and deliver it selectively into EGFR over-expressing tumor cells. dsRB
Externí odkaz:
https://doaj.org/article/5cf736c79c244d99893e7ece5e425c2b
Autor:
Alexander Levitzki, Mark X. Sliwkowski, Anat Globerson Levin, Gabriel Mizraji, Shang-Fan Yu, Jeffrey Lau, Nufar Edinger, Shoshana Klein, Anna Sagalov, Salim Joubran, Alexei Shir, Maya Zigler
Supplementary Material and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba8b54e7bdb6781ac551d6c860fe44e
https://doi.org/10.1158/2326-6066.22538000.v1
https://doi.org/10.1158/2326-6066.22538000.v1
Autor:
Alexander Levitzki, Mark X. Sliwkowski, Anat Globerson Levin, Gabriel Mizraji, Shang-Fan Yu, Jeffrey Lau, Nufar Edinger, Shoshana Klein, Anna Sagalov, Salim Joubran, Alexei Shir, Maya Zigler
The development of targeted therapies that affect multiple signaling pathways and stimulate antitumor immunity is greatly needed. About 20% of patients with breast cancer overexpress HER2. Small molecules and antibodies targeting HER2 convey some sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e4fb8c734f4b546b57e4f28878440a6
https://doi.org/10.1158/2326-6066.c.6548633.v1
https://doi.org/10.1158/2326-6066.c.6548633.v1
Autor:
Alexander Levitzki, Mark X. Sliwkowski, Anat Globerson Levin, Gabriel Mizraji, Shang-Fan Yu, Jeffrey Lau, Nufar Edinger, Shoshana Klein, Anna Sagalov, Salim Joubran, Alexei Shir, Maya Zigler
Supplementary Figure illustrating the difference in cytokine mRNA and protein expression following treatment of BT-474 with pIC/PPHAffibody and pIC/PPCys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67253c4e105aeefd9eb88b5d1004811b
https://doi.org/10.1158/2326-6066.22538006.v1
https://doi.org/10.1158/2326-6066.22538006.v1
Autor:
Suraj J. Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, Frankie D. Heyward, Tyler Sermersheim, Nufar Edinger, Harini Srinivasan, Margo P. Emont, Gregory P. Westcott, Jay Luther, Raymond T. Chung, Shuai Yan, Manju Kumari, Reeby Thomas, Yann Deleye, André Tchernof, Phillip J. White, Guido A. Baselli, Marica Meroni, Dario F. De Jesus, Rasheed Ahmad, Rohit N. Kulkarni, Luca Valenti, Linus Tsai, Evan D. Rosen
Publikováno v:
Sci Transl Med
Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transcriptional r
Autor:
Salim Joubran, Alexander Levitzki, Nufar Edinger, Anna Sagalov, Yael Langut, Shoshana Klein, Efrat Flashner-Abramson, Samarasimhareddy Mamidi, Alexei Shir, Maya Zigler, Alaa Talhami
Publikováno v:
Proceedings of the National Academy of Sciences. 114:13655-13660
There is an urgent need for an effective treatment for metastatic prostate cancer (PC). Prostate tumors invariably overexpress prostate surface membrane antigen (PSMA). We designed a nonviral vector, PEI-PEG-DUPA (PPD), comprising polyethylenimine-po
Autor:
Mark X. Sliwkowski, Alexander Levitzki, Nufar Edinger, Anna Sagalov, Gabriel Mizraji, Shoshana Klein, Shang-Fan Yu, Anat Levin, Alexei Shir, Jeffrey Lau, Maya Zigler, Salim Joubran
Publikováno v:
Cancer Immunology Research. 4:688-697
The development of targeted therapies that affect multiple signaling pathways and stimulate antitumor immunity is greatly needed. About 20% of patients with breast cancer overexpress HER2. Small molecules and antibodies targeting HER2 convey some sur
Autor:
Michael R. Hoopmann, Nufar Edinger, Caroline Haupt, Solis-Mezarino, Michael Götze, Yufei Xiang, Ravit Mesika, Michael J. MacCoss, Ninnis R, Juri Rappsilber, Huang L, Christoph H. Borchers, Heck Ajr, Chris P. Sarnowski, Daniel S. Ziemianowicz, Nesati, Alex Zelter, Francis J. O’Reilly, Cecilia Emanuelsson, Ruedi Aebersold, Gianluca Degliesposti, Christine Piotrowski, Heike Stephanowitz, Alexander Leitner, Nicholas I. Brodie, Dana Reichmann, Nagarjuna Nagaraj, Carolin Sailer, Kasper D. Rand, Karl Mechtler, Fabio C. Gozzo, Amaral Bc, Carla Schmidt, Gutierrez C, Oleg Klykov, Franz Herzog, Manolo Plasencia, Petr Novák, Stéphane Claverol, Florian Stengel, Richard A. Scheltema, Meng-Qiu Dong, Christian E. Stieger, Matthias Pelzing, David C. Schriemer, Juan D. Chavez, Andrea Sinz, Fan Liu, Nir Kalisman, Şule Yılmaz, Jürgen Cox, Yi Shi, Stéphane Chaignepain, Philip C. Andrews, Zdeněk Kukačka, Frank Sobott, Moriya Slavin, Robert L. Moritz, Lolita Piersimoni, Evgeniy V. Petrotchenko, James E. Bruce, Tara L. Pukala, Michael J. Trnka, J. M. Skehel, Claudio Iacobucci, Rosa Viner, Marta Vilaseca
The number of publications in the field of chemical cross-linking combined with mass spectrometry (XL-MS) to derive constraints for protein three-dimensional structure modeling and to probe protein-protein interactions has largely increased during th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39734b91a442fd5fc7e0ef0b4292d8ba
https://doi.org/10.1101/424697
https://doi.org/10.1101/424697
Autor:
Idit Sagiv-Barfi, Alexander Levitzki, Alexei Shir, Yael Langut, Nufar Edinger, Shoshana Klein, Tamar Geiger, Maya Zigler
Publikováno v:
The Journal of infectious diseases. 217(2)
Superantigens (SAgs) are extremely potent bacterial toxins, which evoke a virulent immune response, inducing nonspecific T-cell proliferation, rapid cytokine release, and lethal toxic shock, for which there is no effective treatment. We previously de
Autor:
Yael Levi-Kalisman, Naomi Melamed-Book, Shoshana Klein, Efrat Flashner-Abramson, Nufar Edinger, Mario Lebendiker, Alexander Levitzki, Yael Langut
Publikováno v:
Oncotarget
// Yael Langut 1 , Nufar Edinger 1 , Efrat Flashner-Abramson 1 , Naomi Melamed-Book 2 , Mario Lebendiker 3 , Yael Levi-Kalisman 4 , Shoshana Klein 1 and Alexander Levitzki 1 1 Department of Biological Chemistry, Unit of Cellular Signaling, Silberman