Contribution of direct InhA inhibitors to novel drug regimens in a mouse model of tuberculosis.

Autor: Encinas L; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Li S-Y; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., Rullas-Trincado J; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Tasneen R; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., Tyagi S; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., Soni H; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., Garcia-Perez A; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Lee J; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., González Del Río R; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., De Mercado J; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Sousa V; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., Sosič I; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Gobec S; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Mendoza-Losana A; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Converse PJ; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., Mdluli K; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Fotouhi N; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Barros-Aguirre D; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Nuermberger EL; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Nov 06; Vol. 68 (11), pp. e0035724. Date of Electronic Publication: 2024 Sep 30.

Dose optimization of TBI-223 for enhanced therapeutic benefit compared to linezolid in antituberculosis regimen.

Autor: Strydom N; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy, University of California, San Francisco, CA, USA., Ernest JP; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy, University of California, San Francisco, CA, USA., Imperial M; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy, University of California, San Francisco, CA, USA., Solans BP; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy, University of California, San Francisco, CA, USA., Wang Q; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy, University of California, San Francisco, CA, USA., Tasneen R; Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Tyagi S; Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Soni H; Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Garcia A; Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Bigelow K; Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Gengenbacher M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.; Hackensack Meridian School of Medicine, Hackensack Meridian Health, Nutley, NJ, USA., Zimmerman M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Xie M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Sarathy JP; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Yang TJ; TB Alliance, New York, NY, USA., Dartois V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.; Hackensack Meridian School of Medicine, Hackensack Meridian Health, Nutley, NJ, USA., Nuermberger EL; Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Savic RM; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy, University of California, San Francisco, CA, USA. rada.savic@ucsf.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 25; Vol. 15 (1), pp. 7311. Date of Electronic Publication: 2024 Aug 25.

Enhanced dynamic covalent chemistry for the controlled release of small molecules and biologics from a nanofibrous peptide hydrogel platform.

Autor: Pogostin BH, Wu SX, Swierczynski MJ, Pennington C, Li SY, Vohidova D, Seeley EH, Agrawal A, Tang C, Cabler J, Dey A, Veiseh O, Nuermberger EL, Ball ZT, Hartgerink JD, McHugh KJ

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 23. Date of Electronic Publication: 2024 May 23.

Restocking the tuberculosis drug arsenal.

Autor: Nuermberger EL; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chaisson RE; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA. rchaiss@jhmi.edu.

Publikováno v: Nature medicine [Nat Med] 2024 Mar; Vol. 30 (3), pp. 642-643.

The Many Hosts of Mycobacteria 9 (MHM9): A conference report.

Autor: Klever AM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Alexander KA; Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, VA, USA; CARACAL/Chobe Research Institute Kasane, Botswana., Almeida D; Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD, USA., Anderson MZ; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA; Department of Microbiology, The Ohio State University, Columbus, OH, USA., Ball RL; Eckerd College, St. Petersburg, FL, USA., Beamer G; Host Pathogen Interactions and Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Boggiatto P; Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA., Buikstra JE; Center for Bioarchaeological Research, Arizona State University, Tempe, AZ, USA., Chandler B; Division of Public Health, Alaska Department of Health, AK, USA., Claeys TA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Concha AE; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Converse PJ; Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD, USA., Derbyshire KM; Division of Genetics, The Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Biomedical Sciences, University at Albany, Albany, NY, USA., Dobos KM; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA., Dupnik KM; Center for Global Health, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Endsley JJ; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Endsley MA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Fennelly K; Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, USA., Franco-Paredes C; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA; Hospital Infantil de México Federico Gómez, México, USA., Hagge DA; The Leprosy Mission International, Kathmandu, Nepal., Hall-Stoodley L; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Hayes D Jr; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Hirschfeld K; Department of Anthropology, University of Oklahoma, Norman, OK, USA., Hofman CA; Department of Anthropology, University of Oklahoma, Norman, OK, USA; Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK, USA., Honda JR; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA., Hull NM; Department of Civil, Environmental, and Geodetic Engineering, The Ohio State University, Columbus, OH, USA., Kramnik I; Pulmonary Center, The Department of Medicine, Boston University Chobanian & Aveedisian School of Medicine, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Lacourciere K; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Lahiri R; United States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA, USA., Lamont EA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Larsen MH; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Lemaire T; Norton Sound Health Corporation, Nome, AK, USA., Lesellier S; French Agency for Food, Environmental & Occupational Health & Safety (ANSES), Laboratory for Rabies and Wildlife,Nancy, France., Lee NR; Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ, USA., Lowry CA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Mahfooz NS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., McMichael TM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Merling MR; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Miller MA; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Nagajyothi JF; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Nelson E; Microbial Paleogenomics Unit, Dept of Genomes and Genetics, Institut Pasteur, Paris, France., Nuermberger EL; Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD, USA., Pena MT; United States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA, USA., Perea C; Animal & Plant Health Inspection Service, United States Department of Agriculture, Ames, IA, USA., Podell BK; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA., Pyle CJ; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, USA; Department of Immunology, Duke University School of Medicine, Durham, NC, USA., Quinn FD; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA., Rajaram MVS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Mejia OR; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA., Rothoff M; Division of Public Health, Alaska Department of Health, AK, USA., Sago SA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Salvador LCM; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, USA., Simonson AW; Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Spencer JS; Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA., Sreevatsan S; Pathobiology & Diagnostic Investigation Department, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA., Subbian S; Public Health Research Institute (PHRI), New Jersey Medical School, Rutgers University, Newark, NJ, USA., Sunstrum J; Corewell East Health, Westland, MI, USA., Tobin DM; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, USA; Department of Immunology, Duke University School of Medicine, Durham, NC, USA., Vijayan KKV; Department of Microbiology and Immunology, Center for AIDS Research, and Children's Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wright CTO; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA., Robinson RT; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA. Electronic address: richard.robinson@osumc.edu.

Publikováno v: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2023 Sep; Vol. 142, pp. 102377. Date of Electronic Publication: 2023 Jul 23.