Výsledky vyhledávání - "Nucleotides/genetics"

Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site

Autor: Celso M. Teixeira-Duarte, J.H. Morais Cabral, Fátima Fonseca

Publikováno v: eLife
'eLife ', vol: 8, pages: e50661-1-e50661-28 (2019)
eLife, Vol 8 (2019)

RCK domains regulate the activity of K+ channels and transporters in eukaryotic and prokaryotic organisms by responding to ions or nucleotides. The mechanisms of RCK activation by Ca2+ in the eukaryotic BK and bacterial MthK K+ channels are well unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1924106a515f93f57d68463a95168673
http://europepmc.org/articles/PMC6957272

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Cold adaptation of tRNA nucleotidyltransferases: A tradeoff in activity, stability and fidelity

Autor: Mario Mörl, Heike Betat, Frank Jühling, Lieselotte Erber, Felix G.M. Ernst, Joana Sammler

Publikováno v: RNA Biology
RNA Biology, Taylor & Francis, 2018, 15 (1), pp.144-155. ⟨10.1080/15476286.2017.1391445⟩

PMC5785979; Cold adaptation is an evolutionary process that has dramatic impact on enzymatic activity. Increased flexibility of the protein structure represents the main evolutionary strategy for efficient catalysis and reaction rates in the cold, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d540db0972cb09918ba06ab1e339164
https://hal.archives-ouvertes.fr/hal-03250763

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Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates

Autor: Dominique Sanglard, Luís A. Vale-Silva, Emmanuel Beaudoing, Van Du T. Tran

Publikováno v: G3, vol. 7, no. 8, pp. 2413-2426
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2413-2426 (2017)

Candida glabrata is an important fungal pathogen which develops rapidly antifungal resistance in treated patients. It is known that azole treatments lead to antifungal resistance in this fungal species and that multidrug efflux transporters are invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698ebfa2f035fb1d52c4a933da7ebcdc
https://serval.unil.ch/resource/serval:BIB_CDBF97BBE25A.P001/REF.pdf

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Describing ancient horizontal gene transfers at the nucleotide and gene levels by comparative pathogenicity island genometrics

Autor: François Collyn, Claude-Alain H. Roten, Lionel Guy, Michel Simonet, Michael Marceau

Publikováno v: Bioinformatics, vol. 22, no. 9, pp. 1072-1079

Motivation: Lateral gene transfer is a major mechanism contributing to bacterial genome dynamics and pathovar emergence via pathogenicity island (PAI) spreading. However, since few of these genomic exchanges are experimentally reproducible, it is dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937b36059be157694846987037e7febc
https://doi.org/10.1093/bioinformatics/bti793

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Accuracy and quality assessment of 454 GS-FLX Titanium pyrosequencing

Autor: Thibaut Malausa, André Gilles, Stéphanie Ferreira, Jean-François Martin, Nicolas Pech, Emese Meglécz

Publikováno v: BMC Genomics
BMC Genomics, BioMed Central, 2011, 12 (1), ⟨10.1186/1471-2164-12-245⟩
BMC Genomics, Vol 12, Iss 1, p 245 (2011)
BMC Genomics (12), . (2011)
BMC Genomics, 2011, 12 (1), ⟨10.1186/1471-2164-12-245⟩

Background The rapid evolution of 454 GS-FLX sequencing technology has not been accompanied by a reassessment of the quality and accuracy of the sequences obtained. Current strategies for decision-making and error-correction are based on an initial a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a4b63d6c532c8886e8a282c4143f03
https://hal-montpellier-supagro.archives-ouvertes.fr/hal-01995051/file/document(1).pdf

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New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism

Autor: Doron Lipson, Stylianos E. Antonarakis, Patrice M. Milos, Steve Roels, Philipp Kapranov, Christelle Borel, Fatih Ozsolak, Chris Hart, A. Paula Monaghan, Sang Woo Kim, Sylvain Foissac, Bino John

Publikováno v: Nature
Nature, Nature Publishing Group, 2010, 466 (7306), pp.642-646. ⟨10.1038/nature09190⟩
Nature, Vol. 466, No 7306 (2010) pp. 642-646

Short (< 200 nt) RNA (sRNA) profiling of human cells using various technologies demonstrates unexpected complexity of sRNAs with 100’s of thousands of sRNA species present 1,2,3,4. Genetic and in vitro studies argue that these RNAs are not merely d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a3d4b0cb96c92f496cf95aa94a0958
https://hal.archives-ouvertes.fr/hal-01214708

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Novel human pathological mutations. Gene symbol: SLC3A1. Disease: Cystinuria

Autor: Chatzikyriakidou, A., Kollios, K. D., Ioannis Georgiou

Publikováno v: Scopus-Elsevier

Hum Genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e986809337d9cb554170ba24c6d81fc3
http://olympias.lib.uoi.gr/jspui/handle/123456789/19700

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The Critical cis-Acting Element Required for IMD2 Feedback Regulation by GDP Is a TATA Box Located 202 Nucleotides Upstream of the Transcription Start Site

Autor: Bertrand Daignan-Fornier, Martine A. Collart, Mafalda Escobar-Henriques

Publikováno v: Molecular and Cellular Biology, Vol. 23, No 17 (2003) pp. 6267-78

Guanylic nucleotides are essential cellular players, and the critical enzyme in their tightly regulated synthesis in Saccharomyces cerevisiae is encoded by the IMD2 gene. The transcription of IMD2 is subject to general repression by nutrient limitati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bd09bda550fa3f2750a53c01a895a6
https://europepmc.org/articles/PMC180940/

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