Robust and Sustained STING Pathway Activation via Hydrogel-Based In Situ Vaccination for Cancer Immunotherapy.

Autor: Cheng SL; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.; International Intercollegiate Ph.D. Program, National Tsing Hua University, Hsinchu 30013, Taiwan., Lee HM; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan., Li CP; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Division of Clinical Skills Training, Department of Medical Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Therapeutic and Research Center of Pancreatic Cancer, Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Lin MW; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310401, Taiwan., Chou MY; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310401, Taiwan., Yen YT; Institute of Translational Medicine and New Drug Development, School of Medicine, China Medical University, Taichung 406040, Taiwan., Wu TH; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan., Lian YC; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan., Shih YC; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan., Chiang CS; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan., Chen TW; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Wan D; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan., Chen Y; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.; Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.

Publikováno v: ACS nano [ACS Nano] 2024 Oct 29; Vol. 18 (43), pp. 29439-29456. Date of Electronic Publication: 2024 Oct 15.

Stimulator of Interferon Genes-Activated Biomimetic Dendritic Cell Nanovaccine as a Chemotherapeutic Booster to Enhance Systemic Fibrosarcoma Treatment.

Autor: Wang Z; Department of Hepatobiliary Surgery, Xiang'an Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China., Miao F; Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China., Gu L; Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China., Zhang R; Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China., Ma Y; Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China., Li Y; Heji Hospital Affiliated with Changzhi Medical College, Changzhi 046000, Shanxi, China., Zheng J; Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China., Lin Z; Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China., Gao Y; Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China., Huang L; Fuzhou No. 1 Hospital Affiliated with Fujian Medical University, Fuzhou 350000, Fu Jian, China., Shen Y; Shanghai Jiangxia Blood Technology Co., Ltd. Shanghai 200000, China., Wu T; Cancer Research Center, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China., Luo F; Cancer Research Center, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China., Li W; Department of Hepatobiliary Surgery, Xiang'an Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.

Publikováno v: ACS nano [ACS Nano] 2024 Sep 03; Vol. 18 (35), pp. 24219-24235. Date of Electronic Publication: 2024 Aug 22.

A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance.

Autor: Mertens RT; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Misra A; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Xiao P; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA., Baek S; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea., Rone JM; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Mangani D; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA., Sivanathan KN; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Arojojoye AS; Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA., Awuah SG; Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA; Center for Pharmaceutical Research and Innovation, College of Pharmacy and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA., Lee I; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea; POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea., Shi GP; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Petrova B; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Brook JR; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Anderson AC; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT, USA., Kanarek N; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hemberg M; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nowarski R; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: rnowarski@bwh.harvard.edu.

Publikováno v: Immunity [Immunity] 2024 Sep 10; Vol. 57 (9), pp. 2077-2094.e12. Date of Electronic Publication: 2024 Jun 20.

Delivery of a STING Agonist Using Lipid Nanoparticles Inhibits Pancreatic Cancer Growth.

Autor: Shaji SG; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA., Patel P; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA., Mamani UF; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA., Guo Y; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA., Koirala S; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA., Lin CY; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA., Alahmari M; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA., Omoscharka E; Department of Pathology, University Health/Truman Medical Center, School of Medicine, University of Missouri-Kansas City, Kansas, MO, USA., Cheng K; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.

Publikováno v: International journal of nanomedicine [Int J Nanomedicine] 2024 Aug 27; Vol. 19, pp. 8769-8778. Date of Electronic Publication: 2024 Aug 27 (Print Publication: 2024).

Cyclic nucleotides - the rise of a family.

Autor: Kwiatkowski M; Department of Plant Physiology and Biotechnology, Nicolaus Copernicus University in Toruń, Lwowska St. 1, 87-100 Toruń, Poland., Zhang J; Department of Biology, College of Science, Mathematics, and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou 325060, Zhejiang Province, China., Zhou W; Department of Biology, College of Science, Mathematics, and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou 325060, Zhejiang Province, China., Gehring C; Department of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia 06121, Italy. Electronic address: christophandreas.gehring@unipg.it., Wong A; Department of Biology, College of Science, Mathematics, and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou 325060, Zhejiang Province, China; Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics, Ouhai, Wenzhou 325060, Zhejiang Province, China; Zhejiang Bioinformatics International Science and Technology Cooperation Center, Ouhai, Wenzhou 325060, Zhejiang Province, China. Electronic address: alwong@kean.edu.

Publikováno v: Trends in plant science [Trends Plant Sci] 2024 Aug; Vol. 29 (8), pp. 915-924. Date of Electronic Publication: 2024 Mar 12.