Alternative promoters in CpG depleted regions are prevalently associated with epigenetic misregulation of liver cancer transcriptomes

Autor: Chirag Nepal, Jesper B. Andersen

Publikováno v: Nepal, C & Andersen, J B 2023, ' Alternative promoters in CpG depleted regions are prevalently associated with epigenetic misregulation of liver cancer transcriptomes ', Nature Communications, vol. 14, 2712 . https://doi.org/10.1038/s41467-023-38272-4

Transcriptional regulation is commonly governed by alternative promoters. However, the regulatory architecture in alternative and reference promoters, and how they differ, remains elusive. In 100 CAGE-seq libraries from hepatocellular carcinoma patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40d8087079cfd0f686daad42602d97b
https://curis.ku.dk/ws/files/346531529/s41467_023_38272_4.pdf

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

Autor: Arimura, Y., Tachiwana, H., Takagi, H., Hori, T., Kimura, Hiroshi, Fukagawa, T., Kurumizaka, H.

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications

Centromeric nucleosomes are composed of the centromere-specific histone H3 variant CENP-A and the core histones H2A, H2B, and H4. To establish a functional kinetochore, histone H4 lysine-20 (H4K20) must be monomethylated, but the underlying mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6094ec20ee267479939d26b32b54b4
https://doaj.org/article/b792e5547ea1411d9cc207781efaa5ba

Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins

Autor: Sandya Subramanian, Erika Shor, Timothy Hoggard, Michael Weinreich, Edel M. Hyland, Fu-Jung Chang, Jessica Kenworthy, Catherine A. Fox, Jef D. Boeke, Julie Chueng, Kelsey Rae Perry

Publikováno v: PLoS Genetics, Vol 14, Iss 5, p e1007418 (2018)
Hoggard, T A, Chang, F, Perry, K R, Subramanian, S, Kenworthy, J, Chueng, J, Shor, E, Hyland, E M, Boeke, J D, Weinreich, M & Fox, C A 2018, ' Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins ', PLoS Genetics, vol. 14, no. 5, pp. e1007418 . https://doi.org/10.1371/journal.pgen.1007418
PLoS Genetics

Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f3a624f5325cda21023ddcc285f771
http://europepmc.org/articles/PMC5991416?pdf=render

A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver

Autor: Fukunaga, S., Kanda, G., Tanase, J., Harashima, H., Ohyama, T., Kamiya, H.

Publikováno v: Gene therapy. 19(8):828-835

The intranuclear disposition of plasmid DNA is extremely important for transgene expression. The interactions between the plasmid DNA and the histone proteins are one of the keys for controlling the disposition. In this study, the effects of a left-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::a0d24aaa0ea97fe1076c755a45142038
http://hdl.handle.net/2115/52121

Nuclear factor I genomic binding associates with chromatin boundaries

Autor: Giovanna Ambrosini, Jan Kerschgens, A. Gaussin, Giovani Dietler, Jozef Adamcik, Nicolas Mermod, Christoph D. Schmid, Philipp Bucher, Genta Plasari, Petar Pjanic, Milos Pjanic

Publikováno v: BMC Genomics, vol. 14, pp. 99
BMC Genomics

Background: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation. Using chromatin immuno-precipitation and high throughput se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f290c75e051309871e5b8c7b68dbbdf
https://edoc.unibas.ch/28776/