Zobrazeno 1 - 10
of 2 028
pro vyhledávání: '"Nucleoside analogues"'
Autor:
Konstantin V. Kozlov, Oleg V. Maltsev, Kristina V. Kasyanenko, Vitalii S. Sukachev, Yuri I. Lyashenko, Anastasia A. Kosuhina
Publikováno v:
Терапевтический архив, Vol 96, Iss 8, Pp 797-803 (2024)
Aim. To evaluate the clinical effectiveness, safety and compare the incidence of hospitalization during treatment with antiviral drugs with a direct mechanism of action (riamilovir and umifenovir) in people with acute respiratory viral infections (AR
Externí odkaz:
https://doaj.org/article/4026690b9cb546b495982bed9b96dacd
Autor:
Cassandra Present, Roberson Donola Girão, Cai Lin, Guy Caljon, Serge Van Calenbergh, Otacilio Moreira, Leonardo Alexandre de Souza Ruivo, Marcos Meuser Batista, Raquel Azevedo, Denise da Gama Jaen Batista, Maria de Nazaré Correia Soeiro
Publikováno v:
Parasitology, Vol 151, Pp 506-513 (2024)
Leishmania is a trypanosomatid parasite that causes skin lesions in its cutaneous form. Current therapies rely on old and expensive drugs, against which the parasites have acquired considerable resistance. Trypanosomatids are unable to synthesize pur
Externí odkaz:
https://doaj.org/article/fdbc09b2ce2b46c1a1ac11bb0c9763fd
Autor:
K. V. Zhdanov, О. V. Maltsev, K. V. Kasyanenko, K. V. Kozlov, V. S. Sukachev, N. I. Lvov, V. V. Sharabhanov
Publikováno v:
Антибиотики и Химиотерапия, Vol 68, Iss 9-10, Pp 63-71 (2024)
Aim. To study the efficacy and safety of Riamilovir in patients diagnosed with acute respiratory viral infection using several dosage regimens of the drug.Material and Methods. The clinical efficacy and safety of Riamilovir were evaluated based on th
Externí odkaz:
https://doaj.org/article/34781a5941ea4b1d8b4ccd5130eb0c10
Autor:
Naveen Kumar, Sanjeev Kumar, Alok Shukla, Sanjay Kumar, Rishi Kant Singh, Ilya Ulasov, Sandeep Kumar, Anand Kumar Patel, Lokesh Yadav, Ruchi Tiwari, Rachana, Shivashish Priyadarshi Mohanta, Kaushalendra, Vikram Delu, Arbind Acharya
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Purpose T-cell lymphomas, refer to a diverse set of lymphomas that originate from T-cells, a type of white blood cell, with limited treatment options. This investigation aimed to assess the efficacy and mechanism of a novel fluorinated nucle
Externí odkaz:
https://doaj.org/article/b69e853613c94f9fbb52569ed28d295e
Autor:
Konstantin V. Zhdanov, Oleg V. Maltsev, Kristina V. Kasyanenko, Konstantin V. Kozlov, Vitalii S. Sukachev, Nikolai I. Lvov, Valerian V. Sharabkhanov, Alexander A. Litvinov
Publikováno v:
Терапевтический архив, Vol 95, Iss 11, Pp 930-936 (2023)
Aim. To evaluate the clinical efficacy and safety of antiviral drug riamilovir in patients with acute respiratory viral infections (ARVI) of non-coronavirus (SARS-CoV-2) etiology with different dosing regimens. Materials and methods. The study inc
Externí odkaz:
https://doaj.org/article/aae55b48a53c4cc6a36b8e0da0f4e7d8
Autor:
Irina A. Bychek, Anastasia A. Zenchenko, Maria A. Kostromina, Marat M. Khisamov, Pavel N. Solyev, Roman S. Esipov, Sergey N. Mikhailov, Irina V. Varizhuk
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1069 (2024)
The enzymatic synthesis of nucleoside derivatives is an important alternative to multi-step chemical methods traditionally used for this purpose. Despite several undeniable advantages of the enzymatic approach, there are a number of factors limiting
Externí odkaz:
https://doaj.org/article/72697b09fb0e4f97ab3e3b61f244b639
Publikováno v:
Molecules, Vol 29, Iss 16, p 3767 (2024)
Nucleosides, nucleotides, and their analogues are an important class of molecules that are used as substrates in research of enzymes and nucleic acid, or as antiviral and antineoplastic agents. Nucleoside phosphorylation is usually achieved with chem
Externí odkaz:
https://doaj.org/article/e1379b9c37a34d9ba773f9fe81ca106a
Autor:
Rehan Deshmukh, Utpal Roy
Publikováno v:
Journal of Pure and Applied Microbiology, Vol 17, Iss 1, Pp 1-11 (2023)
The world has been rocked by the 2019 coronavirus disease (COVID-19), which has significantly changed our way of life. Despite the unusual measures taken, COVID-19 still exists and affects people all over the world. A remarkable amount of study has b
Externí odkaz:
https://doaj.org/article/22fddfc0b65044578e67b70d60016c9f
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Autor:
Dorien Mabille, Kayhan Ilbeigi, Sarah Hendrickx, Marzuq A. Ungogo, Fabian Hulpia, Cai Lin, Louis Maes, Harry P. de Koning, Serge Van Calenbergh, Guy Caljon
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 21-30 (2022)
Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleos
Externí odkaz:
https://doaj.org/article/67220a1220024591ad64ccc816d06c7e