Zobrazeno 1 - 10 of 553 pro vyhledávání: '"Nucleophilic acyl substitution"'
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Akademický článek
Synthesis, characterization and crystal structure of pentyl 2-(1H-indole-2-carboxamido)benzoate
Autor: Kamal Sweidan, Monther Khanfar, A. Al-Shamaileh, Mahmoud Sunjuk, Rajendra Joshi
Publikováno v: Current Chemistry Letters, Vol 8, Iss 1, Pp 63-68 (2018)
Pentyl 2-(1H-indole-2-carboxamido)benzoate (5) is obtained in good yield as stable crystals by reaction of pentyl 2-amino benzoate (6) with indole-2-carbonyl chloride acid (7) in the presence of pyridine. The crystal structure of 5 confirms the prese
Externí odkaz: https://doaj.org/article/b31677feb8944142af565da68f430942
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2
Benzylic aroylation of toluenes with unactivated tertiary benzamides promoted by directed ortho-lithiation
Autor: Bing-Tao Guan, Hui-Zhen Du, Yan-Long Luo, Can-Can Bao
Publikováno v: Science China Chemistry. 64:1349-1354
The deprotonative functionalization of toluenes, for their weak acidity, generally needs strong bases, thus leading to the requirement of harsh conditions and the generation of by-products. Direct nucleophilic acyl substitution reaction of amides wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe537e579682f758bd964c3350f16243
https://doi.org/10.1007/s11426-021-1035-5
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4
Synthesis of Substituted Phthalimides via Ultrasound-Promoted One-Pot Multicomponent Reaction
Autor: Christoph Janiak, Abdolali Alizadeh, Behnaz Farajpour, Tim-Oliver Knedel
Publikováno v: The Journal of Organic Chemistry. 86:574-580
In this work, a novel strategy for the straightforward synthesis of substituted phthalimides is described, which includes base-mediated Michael addition/intramolecular cyclization/[1,5]-H shift/cleavage of CS2/aromatization/nucleophilic acyl substitu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f81b77e01ecbfe6e622f3ad363ea077b
https://doi.org/10.1021/acs.joc.0c02245
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5
Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety
Autor: Andrea Angeli, Zeynep Gönül, Gianluca Bartolucci, Hasan Kucukbay, Fatumetuzzehra Küçükbay, Claudiu Supuran, AlessanRSS Reis
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1021-1026 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
New dipeptide–dihydroquinolinone derivatives were successfully synthesised by benzotriazole mediated nucleophilic acyl substitution reaction and their structures were elucidated by spectroscopic and analytic techniques. The carbonic anhydrase (CA,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ef3941a6c1bc6fb7acc6b0c97a916d
https://doaj.org/article/7891745f096745c19eef8332aaea68a3
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6
Transition metal-free domino acyl substitution/Michael addition of alkenyl Grignard reagents to lactam esters: synthesis of lactam-bearing homoallylic ketones
Autor: Muhannad Rabah, Timothy K. Beng, Abdikani Omar Farah
Publikováno v: RSC Advances. 10:22454-22459
A solvent-controlled protocol for the direct and transition metal-free addition of alkenyl Grignard reagents to vicinally functionalized sp3-rich morpholinones has been developed, leading to the chemo and regioselective synthesis of lactam-bearing ho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b863bab4e32d6d65814e4d5b37499600
https://doi.org/10.1039/d0ra03885g
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8
Facile Synthesis of Alkylidene Phthalides by Rhodium-Catalyzed Domino C-H Acylation/Annulation of Benzamides with Aliphatic Carboxylic Acids
Autor: Xiaofeng Zhang, Hongyi Li, Bangyue He, Yaping Shang, Sien Liu, Weiping Su
Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 27(63)
The Rh-catalyzed ortho-C(sp2 )-H functionalization of 8-aminoquinoline-derived benzamides with aliphatic acyl fluorides generated in situ from the corresponding acids has been developed. This reaction initiated with 8-aminoquinoline-directed ortho-C(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bf53214ec7504737d43f0b010b84ac
https://pubmed.ncbi.nlm.nih.gov/34519367
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9
Tandem Acyl Substitution/Michael Addition of Thioesters with Vinylmagnesium Bromide
Autor: Vera Hirschbeck, Ivana Fleischer, Marlene Böldl, Paul H. Gehrtz
Publikováno v: Organic Letters. 21:2578-2582
A tandem reaction of thioesters with vinylmagnesium bromide is reported. The initial acyl substitution provides an α,β-unsaturated ketone which further reacts with the liberated thiolate. This transition-metal-free synthesis of β-sulfanyl ketones
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96457312be30f736168e9067c1619352
https://doi.org/10.1021/acs.orglett.9b00538
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10
Directed ortho-metalation–nucleophilic acyl substitution strategies in deep eutectic solvents: the organolithium base dictates the chemoselectivity
Autor: Cristina Prandi, Simone Ghinato, Vito Capriati, Giuseppe Dilauro, Marco Blangetti, Filippo Maria Perna
Publikováno v: Chemical Communications. 55:7741-7744
Directed ortho metalation (DoM) or nucleophilic acyl substitution (SNAc) can be efficiently programmed on the same aromatic carboxylic acid amide, in a choline chloride-based eutectic mixture, by simply switching the nature of the organolithium reage
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124b9b7bb83828f76268ca48d30d5c72
https://doi.org/10.1039/c9cc03927a
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