Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Nucleic Acid Synthesis Inhibitor"'
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing the outbreak of severe acute respiratory syndrome–coronavirus 2 (CoV-2). Remdesivir (RDV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9314abf1827086422996ad7e1935e8a
https://pubmed.ncbi.nlm.nih.gov/32094225
https://pubmed.ncbi.nlm.nih.gov/32094225
Publikováno v:
Modern Crop Protection Compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86c4df351a9b81f0a0e786fa637b44f0
https://doi.org/10.1002/9783527699261.ch25
https://doi.org/10.1002/9783527699261.ch25
Publikováno v:
Forensic Science International: Genetics. 24:55-59
Inhibitors of polymerase chain reaction (PCR) amplification often present a challenge in forensic investigations of e.g., terrorism, missing persons, sexual assaults and other criminal cases. Such inhibitors may be counteracted by dilution of the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f876a0a10240cba70613c81e9dfb426
https://doi.org/10.1016/j.fsigen.2016.05.017
https://doi.org/10.1016/j.fsigen.2016.05.017
Autor:
Kristina R. Chacko, Paul J. Gaglio
Publikováno v:
Clinics in Liver Disease. 19:605-617
This article discusses direct-acting antiviral agents that target hepatitis C virus replication, their mechanism of action, strengths, and weaknesses. In addition, varying strategies using combinations of these agents are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3192c6cb147e6e76b2e900006db07377
https://doi.org/10.1016/j.cld.2015.06.002
https://doi.org/10.1016/j.cld.2015.06.002
Autor:
M. A. Makhotkin, N. V. Boiko, I. E. Chikunov, D. G. Matishov, A. A. Kirpii, A. N. Mashkarina, V. A. Tarasov, A. V. Naboka, E. F. Shin, M. G. Tyutyakina
Publikováno v:
Doklady Biochemistry and Biophysics. 467:99-101
It was first shown that DNA damage induction in mitomycin C-treated HeLa cells leads to a change in the selection of 5p and 3p microRNA duplex strands in the formation of the RNA-induced silencing complex (RISC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fafda329167872800b12341da5056a4
https://doi.org/10.1134/s160767291602006x
https://doi.org/10.1134/s160767291602006x
Autor:
Daniel J. Wilson, Eva Nagy, Lena Miller, Jayakanth Kankanala, Michael A. Parniak, Zhengqiang Wang, Karen A. Kirby, Sanjeev Kumar V. Vernekar, Zheng Liu, Stefan G. Sarafianos
Publikováno v:
Journal of Medicinal Chemistry
Reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not targeted by current chemotherapy against human immunodeficiency virus (HIV). Although numerous chemotypes have been reported to inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcbc72caf7bcca09c19b4a7d2899aca
https://doi.org/10.1021/jm501132s
https://doi.org/10.1021/jm501132s
Publikováno v:
Expert Opinion on Pharmacotherapy. 15:2361-2372
Intensive laboratory, preclinical and clinical studies have identified and validated molecular targets in cancers, leading to a shift toward the development of novel, rationally designed and specific therapeutic agents. However, gastrointestinal canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9a11af576f016de7891de4e57df735
https://doi.org/10.1517/14656566.2014.958074
https://doi.org/10.1517/14656566.2014.958074
Autor:
Kaan Yilancioglu
Publikováno v:
Antibiotics
Antibiotics, Vol 8, Iss 3, p 114 (2019)
Volume 8
Issue 3
Antibiotics, Vol 8, Iss 3, p 114 (2019)
Volume 8
Issue 3
Antimicrobial multidrug resistance and its transmission among strains are serious problems. Success rate is decreased and treatment options are narrowed due to increasing bacterial multidrug resistance. On the other hand, the need for long-term effor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d416564cff9b49b9d815c6b94fb48e20
https://doi.org/10.3390/antibiotics8030114
https://doi.org/10.3390/antibiotics8030114
Publikováno v:
Food Chemistry. 141:1000-1007
During the screening of selective DNA polymerase (pol) inhibitors, we isolated cycloartenyl trans-ferulate (CAF), which is a major component of γ-oryzanol, which is a byproduct formed during the production of Japanese rice wine "sake". CAF selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf062ff9ad7ddf4e48e78c79f76f875
https://doi.org/10.1016/j.foodchem.2013.04.048
https://doi.org/10.1016/j.foodchem.2013.04.048
Publikováno v:
ChemMedChem. 11(13)
Iridium-based metal complexes containing polypyridyl-pyrazine ligands show properties of DNA intercalation. They serve as roadblocks to DNA polymerase activity, thereby inhibiting the polymerization process. Upon the addition of increasing concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03b4fbde4236ef78b51086acf4c685d
https://pubmed.ncbi.nlm.nih.gov/27240728
https://pubmed.ncbi.nlm.nih.gov/27240728