Zobrazeno 1 - 10
of 10 341
pro vyhledávání: '"Nuclear factor-κB"'
Autor:
Fei-fei Guan, Zhao-xu Han
Publikováno v:
Linchuang shenzangbing zazhi, Vol 24, Iss 9, Pp 760-771 (2024)
Objective To explore the effect of allicin on renal injury in rats with membranous nephropathy （MN） and elucidate its potential mechanism. Methods A total of 65 male Wistar rats were assigned into two groups of normal （n = 10） and modeling
Externí odkaz:
https://doaj.org/article/dd9293f9208b4035b46cc786cde65431
Publikováno v:
Shipin gongye ke-ji, Vol 45, Iss 16, Pp 340-347 (2024)
Objective: To investigate the effect and mechanism of Hippophae rhamnoides flavone (HRF) on polycystic ovarian syndrome (PCOS) in rats, and to provide new ideas for the prevention and treatment of PCOS. Methods: A PCOS rat model was duplicated by giv
Externí odkaz:
https://doaj.org/article/5f6eaec194a9434398d23e58bee4909a
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117367- (2024)
The pyroptosis of cardiomyocytes has become an essential topic in heart failure research. The abnormal accumulation of these biological factors, including angiotensin II, advanced glycation end products, and various growth factors (such as connective
Externí odkaz:
https://doaj.org/article/8402e07d41bc4889a55b01347fe46c01
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Loss-of-function mutations in nucleotide-binding oligomerization domain 2 (NOD2) constitute the primary risk factors for Crohn’s disease. NOD2 is an intracellular sensor for muramyl dipeptide (MDP), a small molecule derived from the peptidoglycan l
Externí odkaz:
https://doaj.org/article/9f173f2b96d5413bae2d4fdf8f772407
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 4, Pp 489-495 (2024)
Objective To explore the therapeutic effect and mechanism of pachymic acid(PA) on Helicobacter pylori(Hp)-associated gastritis in rats. Methods A rat model of Hp-associated gastritis was established; all rats were separated into control group(CT grou
Externí odkaz:
https://doaj.org/article/b3c0928b34be40949c40b5bbd28960f9
Autor:
Liying Shan, Xiaoxia Liao, Xiaoli Yang, Endong Zhu, Hairui Yuan, Jie Zhou, Xiaoxia Li, Baoli Wang
Publikováno v:
Genes and Diseases, Vol 12, Iss 1, Pp 101209- (2025)
Naked cuticle homolog 2 (NKD2) has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor. The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully understood. In this study, we identi
Externí odkaz:
https://doaj.org/article/9689ba4d45e545a5b86f6539ccc9f2cc
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Objective This study was designed to observe the effect of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway activity on sepsis-associated acute kidney injury (SA-AKI), thereby providing new considerations for the prevention and tre
Externí odkaz:
https://doaj.org/article/535110157df24377afd50559a4bcfc3e
Autor:
Jie Yuan, Bhanuprakash C. Narasimhachar, Akshay Ravish, Li Yang, Hua Zhang, Qun Wang, Zhi Li, Jun Huang, Bei Wang, Geng Wang, Keshav Kumar Harish, Arunachalam Chinnathambi, Chandramohan Govindasamy, Mahendra Madegowda, Basappa Basappa
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionNuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and piperazine-lin
Externí odkaz:
https://doaj.org/article/66c2cc0a7bac4368a394f36398fd78cd
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34509- (2024)
Macrophages are important for maintaining tissue homeostasis and defending against pathogens in periodontal tissues. However, these tissues are often vulnerable to damage due to local inflammatory responses within the host tissues. This study aimed t
Externí odkaz:
https://doaj.org/article/55bf5a3571b4495da28a1c7cf259d1bb
Publikováno v:
Endocrine Journal, Vol 71, Iss 4, Pp 417-427 (2024)
Lipopolysaccharide (LPS) and Receptor Activator of Nuclear Factor-κB Ligand (RANKL) are the two important factors causing bone loss, which is an important pathogenesis for osteoporosis. However, the relationship between LPS and RANKL is not yet clea
Externí odkaz:
https://doaj.org/article/17dc99b2950a44d1b47acb7ba13b272d