Výsledky vyhledávání - "Nuclear Proteins/physiology"

TWIST1 upregulation affects E-cadherin expression in brain metastases

Autor: Anja Bukovac, Petar Brlek, Nives Pećina-Šlaus, Anja Kafka

Publikováno v: Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 23(6)

Purpose: E-cadherin is a calcium-dependent glycoprotein whose main role is cell-cell adhesion. Its transcriptional repressor TWIST1 is a basic helix-loop-helix (bHLH) protein that participates in gastrulation and formation of mesodermal tissues durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5d91b3fff23ecb4392c81740e70b1f
https://pubmed.ncbi.nlm.nih.gov/33006113

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Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

Publikováno v: Cancer Cell, Vol. 32, No 4 (2017) pp. 444-459.e7

Proper organization of the mitotic spindle is key to genetic stability, but molecular components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still largely unknown. Here we identify a kinase-independent function of cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd23d035f5c1e2c0a81a3e6f5cba9da
https://archive-ouverte.unige.ch/unige:107106

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SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown

Autor: Patrick Meraldi, Daniel W. Gerlich, Alberto Toso, Yagmur Turgay, Ulrike Kutay, Lysie Champion, Csaba Balazs, Michael Held

Publikováno v: The Journal of Cell Biology
The Journal of Cell Biology, Vol. 204, No 7 (2014) pp. 1099-109
JOURNAL OF CELL BIOLOGY

SUN proteins in the inner nuclear membrane function in mitotic membrane remodeling during nuclear envelope breakdown.
SUN proteins reside in the inner nuclear membrane and form complexes with KASH proteins of the outer nuclear membrane that conn

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The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms

Autor: Valerio Pazienza, Michelangelo Foti, Francesco Negro, Sophie Clément, Alessandra Mangia, Paolo Pugnale, Stéphanie Conzelman

Publikováno v: Hepatology, Vol. 45, No 5 (2007) pp. 1164-71

Both molecular and clinical evidence support a link between HCV infection and insulin resistance. We examined the in vitro interaction between the HCV core protein of genotypes 3a and 1b with the insulin-signaling pathway. We measured the expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddeee949b31fe1f48e40c15b4b9dc061
https://doi.org/10.1002/hep.21634

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Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

Autor: Bodo Grimbacher, Annette Schmitt-Graeff, A. D. B. Webster, Qiang Pan-Hammarström, Michael Schlesier, Jürgen K. Rockstroh, Ulrich Salzer, Pascal Schneider, Lennart Hammarström, Hans-Hartmut Peter, Alejandro A. Schäffer, Helen Chapel

Publikováno v: Nature Genetics, vol. 37, no. 8, pp. 820-828

The functional interaction of BAFF and APRIL with TNF receptor superfamily members BAFFR, TACI and BCMA is crucial for development and maintenance of humoral immunity in mice and humans. Using a candidate gene approach, we identified homozygous and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042c023982477131bc66639caf3e4f71
https://doi.org/10.1038/ng1600

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Fibroblast Growth Factor Receptor Signaling Promotes Radial Glial Identity and Interacts with Notch1 Signaling in Telencephalic Progenitors

Autor: Susana Vaz Nery, Nicholas Gaiano, Gord Fishell, Keejung Yoon, Freddy Radtke, Michael Rutlin

Publikováno v: The Journal of Neuroscience. 24:9497-9506

The Notch and fibroblast growth factor (FGF) pathways both regulate cell fate specification during mammalian neural development. We have shown previously that Notch1 activation in the murine forebrain promotes radial glial identity. This result, toge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d90ada8438fda00ff15bb6dc979e469
https://doi.org/10.1523/jneurosci.0993-04.2004

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Genome-wide analysis of gene expression reveals function of the bZIP transcription factor HY5 in the UV-B response of Arabidopsis

Autor: Eberhard Schäfer, Attila Oravecz, Alexander Baumann, Ferenc Nagy, Edward J. Oakeley, Roman Ulm, Zoltán Máté, Éva Ádám

Publikováno v: Proceedings of the National Academy of Sciences, Vol. 101, No 5 (2004) pp. 1397-1402

The light environment is a key factor that governs a multitude of developmental processes during the entire life cycle of plants. An important and increasing part of the incident sunlight encompasses a segment of the UV-B region (280–320 nm) that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf05f9ff0bcb33d4d081beeefdbee314
https://doi.org/10.1073/pnas.0308044100

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Bimodal expression of PHO84 is modulated by early termination of antisense transcription

Autor: Françoise Stutz, Samir Rahman, Manuele Castelnuovo, Daniel Zenklusen, Valentina Infantino, Elisa Guffanti

Publikováno v: Nature Structural & Molecular Biology, Vol. 20, No 7 (2013) pp. 851-858
Nature structural & molecular biology

Many S. cerevisiae genes encode antisense transcripts some of which are unstable and degraded by the exosome component Rrp6. Loss of Rrp6 results in the accumulation of long PHO84 antisense RNAs and repression of sense transcription through PHO84 pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6f07bfe571ed8f4dfbda6f58f186fa
https://archive-ouverte.unige.ch/unige:36376

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Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana

Autor: Fehér, Balázs, Kozma-Bognár, László, Kevei, Eva, Hajdu, Anita, Binkert, Melanie, Davis, Seth Jon, Schäfer, Eberhard, Ulm, Roman, Nagy, Ferenc

Publikováno v: The Plant Journal, Vol. 67, No 1 (2011) pp. 37-48

Circadian clocks regulate many molecular and physiological processes in Arabidopsis (Arabidopsis thaliana), allowing the timing of these processes to occur at the most appropriate time of the day in a 24-h period. The accuracy of timing relies on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94d1d4f5d74dfde16738d781f0e8f1c9
https://pubmed.ncbi.nlm.nih.gov/21395889

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An NF-χB-like element plays an essential role in interleukin-1-mediated costimulation of the mouse interleukin-2 promoter

Autor: Edgar Serfling, Werner Falk, Kirstin Strieker, Peter H. Krammer

Publikováno v: European Journal of Immunology. 23:1475-1480

Interleukin-1 (IL-1) costimulation is required for efficient IL-2 synthesis and IL-2 receptor (IL-2R) expression of T cells. The molecular events leading to these effects are largely unknown. We utilized an IL-1-responsive and an IL-1-non-responsive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e5dd5889e9f267d52c5d3fe05a7c2
https://doi.org/10.1002/eji.1830230712

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