DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations

Autor: John Gallon, Antonio Rodriguez-Calero, Andrej Benjak, Dilara Akhoundova, Sina Maletti, Ursula Amstutz, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Felix Y. Feng, Silke Gillessen, Charlotte K.Y. Ng, Mark A. Rubin, Salvatore Piscuoglio

Publikováno v: Gallon, John; Rodríguez-Calero, Antonio; Benjak, Andrej; Akhoundova, Dilara; Maletti, Sina; Amstutz, Ursula; Hewer, Ekkehard; Genitsch, Vera; Fleischmann, Achim; Rushing, Elisabeth J; Grobholz, Rainer; Fischer, Ingeborg; Jochum, Wolfram; Cathomas, Gieri; Osunkoya, Adeboye O; Bubendorf, Lukas; Moch, Holger; Thalmann, George; Feng, Felix Y; Gillessen, Silke; ... (2023). DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations. Cancer research, 83(8), pp. 1203-1213. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-22-2236
Cancer research, vol. 83, no. 8, pp. 1203-1213

Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce9031aefed757cc227ffba65be48c1
https://boris.unibe.ch/178505/1/can-22-2236.pdf

The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

Autor: Diederik W. D. Kuster, Michel van Weeghel, Vida Alizadeh Tazehkandi, Luciënne Baks-Te Bulte, Gustav J. Strijkers, Bram F. Coolen, Ntsiki M. Held, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Mariah R R Daal, Marit Wiersma, Rob C. I. Wüst

Publikováno v: Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100 . https://doi.org/10.3390/ijms22084100
International journal of molecular sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(8):4100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 8
Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100, pp. 1-19 . https://doi.org/10.3390/ijms22084100
International Journal of Molecular Sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 4100, p 4100 (2021)

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba143ec8e34cf744f53dea11e2bd5101
https://doi.org/10.3390/ijms22084100

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

Autor: Gavin S. McNee, Jing Zhang, Durga Pokharel, Grant S. Stewart, Ryan C James, Yongqing Zhang, John J. Reynolds, Michael M. Seidman, Marina A. Bellani, Andrew P. Jackson

Publikováno v: Zhang, J, Bellani, M A, James, R C, Pokharel, D, Zhang, Y, Reynolds, J J, McNee, G S, Jackson, A P, Stewart, G S & Seidman, M M 2020, ' DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain ', Nature Communications, vol. 11, no. 1, pp. 3951 . https://doi.org/10.1038/s41467-020-17449-1
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

Duplication of mammalian genomes requires replisomes to overcome numerous impediments during passage through open (eu) and condensed (hetero) chromatin. Typically, studies of replication stress characterize mixed populations of challenged and unchall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c851bb2ae9cc2384921e694cae79affc
https://doi.org/10.1038/s41467-020-17449-1

Right diaphragmatic palsy as a cause of QRS alternans

Autor: Anne-Lise Hachulla, Philippe Meyer, Nicolas Johner, Jean-Paul Janssens

Publikováno v: European Heart Journal, Vol. 41, No 21 (2020) P. 2039

Loss of body mass and exercise intolerance are common findings in chronic obstructive pulmonary disease and are often difficult to reverse despite optimal nutritional intake. Similar findings have been reported in healthy individuals during high-alti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7950496e46f4f01df9318dd18b3b9e
https://archive-ouverte.unige.ch/unige:154588

Microtubule end conversion mediated by motors and diffusing proteins with no intrinsic microtubule end-binding activity

Autor: Maxim Godzi, Fazly I. Ataullakhanov, Ekaterina L. Grishchuk, Ekaterina V. Tarasovetc, Manas Chakraborty, Ana C. Figueiredo, Anatoly V. Zaytsev

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Accurate chromosome segregation relies on microtubule end conversion, the ill-understood ability of kinetochores to transit from lateral microtubule attachment to durable association with dynamic microtubule plus-ends. The molecular requirements for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e54311e9b3649648ad42a8f1d75ff3
http://europepmc.org/articles/PMC6459870