Výsledky vyhledávání - "Nuclear Proteins/genetics/*metabolism"

Subnuclear gene positioning through lamina association affects copper tolerance

Autor: Sakamoto, Y., Sato, M., Sato, Y., Harada, A., Suzuki, T., Goto, C., Tamura, K., Toyooka, K., Kimura, Hiroshi, Ohkawa, Y., Hara-Nishimura, I., Takagi, S., Matsunaga, S.

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

The nuclear lamina plays an important role in the regulation of chromatin organization and gene positioning in animals. CROWDED NUCLEI (CRWN) is a strong candidate for the plant nuclear lamina protein in Arabidopsis thaliana but its biological functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949272ba3b3b82233de1724517e6100f
https://doaj.org/article/c86f370d5995440ea4edd12a155f947b

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Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

Autor: Ludwig A. Hothorn, Joka Pipercevic, Sebastian Hiller, Rebekka Wild, Robert K. Harmel, Jinsheng Zhu, Michael Hothorn, Dorothea Fiedler, Kristina Sturm, Larissa Broger, Martina Katharina Ried, Luciano A. Abriata

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.384. ⟨10.1038/s41467-020-20681-4⟩
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.384. ⟨10.1038/s41467-020-20681-4⟩
Nature Communications 12 (2021), Nr. 1
Nature Communications, Vol. 12, No 384 (2021)

Phosphorus is an essential nutrient taken up by organisms in the form of inorganic phosphate (Pi). Eukaryotes have evolved sophisticated Pi sensing and signaling cascades, enabling them to stably maintain cellular Pi concentrations. Pi homeostasis is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b14105c08592d3d2097a82178d60b5
https://hal.science/hal-03328790/document

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mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution

Autor: Antonina Hafner, Gerald R. Crabtree, Christopher M. Weber, Jacob G. Kirkland, Benjamin Z. Stanton, Alistair N. Boettiger, Simon M. G. Braun

Publikováno v: Nature Structural & Molecular Biology, Vol. 28, No 6 (2021) pp. 501-511
Nat Struct Mol Biol

The mammalian SWI/SNF complex, or BAF complex, has a conserved and direct role in antagonizing Polycomb-mediated repression. Yet, BAF also promotes repression by Polycomb in stem cells and cancer. How BAF both antagonizes and promotes Polycomb-mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d553f63fe89284877c325a5813a60c66
https://archive-ouverte.unige.ch/unige:154515

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A conserved splicing mechanism of the LMNA gene controls premature aging

Autor: Jamal Tazi, Isabelle Behm-Ansmant, José M.P. Freije, Claire Navarro, James Stévenin, Annachiara De Sandre-Giovannoli, Fernando G. Osorio, Isabel C. Lopez-Mejia, Cyril F. Bourgeois, Christiane Branlant, Nicolas Lévy, Carlos López-Otín, Valentin Vautrot, Marion de Toledo

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2011, 20 (23), pp.4540-4555. ⟨10.1093/hmg/ddr385⟩
Human Molecular Genetics, 2011, 20 (23), pp.4540-4555. ⟨10.1093/hmg/ddr385⟩
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Human Molecular Genetics, Oxford University Press (OUP), 2011, 20 (23), pp.4540--55. ⟨10.1093/hmg/ddr385⟩

International audience; Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder phenotypically characterized by many features of premature aging. Most cases of HGPS are due to a heterozygous silent mutation (c.1824C\textgreaterT; p.Gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d814b0799cc4a5ebd703c809c3ce67
https://doi.org/10.1093/hmg/ddr385

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A wave of nascent transcription on activated human genes

Genome-wide studies reveal that transcription by RNA polymerase II (Pol II) is dynamically regulated. To obtain a comprehensive view of a single transcription cycle, we switched on transcription of five long human genes (>100 kbp) with tumor necrosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb364651bfa42025113982760f966bd4
https://ora.ox.ac.uk/objects/uuid:7a6527f5-5557-40c7-b3ee-9dcf50baddea

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New pool of cortical interneuron precursors in the early postnatal dorsal white matter

Autor: Cécile Lebrand, Jozsef Zoltan Kiss, O Riccio, Sahana Murthy, Alexandre Dayer, Gábor Szabó, Laszlo Vutskits, Tania Vitalis

Publikováno v: Cerebral cortex (New York N.Y. : 1991)
Cerebral Cortex
Cerebral Cortex, vol. 22, no. 1, pp. 86-98
Cerebral Cortex, Vol. 22, No 1 (2012) pp. 86-98

The migration of cortical γ-aminobutyric acidergic interneurons has been extensively studied in rodent embryos, whereas few studies have documented their postnatal migration. Combining in vivo analysis together with time-lapse imaging on cortical sl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3ec69afe3edee46e752dc669e1ea96

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ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells

Autor: Francesca Frigerio, Søren Fisker Schmidt, Lars la Cour Poulsen, Pierre Maechler, Michael Boergesen, Susanne Mandrup

Publikováno v: The Journal of biological chemistry
Boergesen, M, Poulsen, L L C, Schmidt, S F, Frigerio, F, Maechler, P & Mandrup, S 2011, ' ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor {alpha} Expression in Pancreatic {beta}-Cells ', Journal of Biological Chemistry, vol. 286, no. 15, pp. 13214-13225 . https://doi.org/10.1074/jbc.M110.215467
Journal of Biological Chemistry, Vol. 286, No 15 (2011) pp. 13214-25

Chronic exposure to elevated levels of glucose and fatty acids leads to dysfunction of pancreatic β-cells by mechanisms that are only partly understood. The transcription factor peroxisome proliferator-activated receptor α (PPARα) is an important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae9b8a2ff1fd58876384a3edb2c9166

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Histone Acetyltransferase Cofactor Trrap Is Essential for Maintaining the Hematopoietic Stem/Progenitor Cell Pool

Autor: Andreas Trumpp, Carla Sawan, Rabih Murr, Zhao-Qi Wang, Zdenko Herceg, Gabriela M. Oser, Joanna I. Loizou, Vivek Shukla

Publikováno v: Journal of Immunology, Vol. 183, No 10 (2009) pp. 6422-31

The pool of hematopoietic stem/progenitor cells, which provide life-long reconstitution of all hematopoietic lineages, is tightly controlled and regulated by self-renewal and apoptosis. Histone modifiers and chromatin states are believed to govern es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382c6d693083645a966552013f39b655
https://doi.org/10.4049/jimmunol.0901969

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Coordination of dual incision and repair synthesis in human nucleotide excision repair

Autor: Jacqueline H. Enzlin, Adebanke F. Fagbemi, Giuseppina Giglia-Mari, Wim Vermeulen, Stuart G. Clarkson, Lidija Staresincic, Audrey M. Gourdin, Isabelle Dunand-Sauthier, Orlando D. Schärer, Nils Wijgers

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2009, 28 (8), pp.1111-1120. ⟨10.1038/emboj.2009.49⟩
EMBO Journal, Vol. 28, No 8 (2009) pp. 1111-1120
EMBO Journal, 28(8), 1111-1120. Wiley-Blackwell

Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the involved proteins at sites of DNA damage. Following damage recognition, dual incision 5' to the lesion by ERCC1-XPF and 3' to the lesion by XPG leads to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272338a7bb4b863e64e94c3bd36259ba
https://doi.org/10.1038/emboj.2009.49

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