Zobrazeno 1 - 10
of 490
pro vyhledávání: '"Nuclear Lamins"'
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significa
Externí odkaz:
https://doaj.org/article/b7ff68354deb4ed4af99500f91c6b65f
Autor:
Lin Batha, Mohammad Azhar Aziz, Mahmoud Zhra, Jasmine Holail, Wedad S. Al-Qahtani, Rajaa Fakhoury, Ahmad Aljada
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 6, p 113 (2023)
Background: Lamins are the major component of nuclear lamina. Alternative splicing of the 12 exons comprising lamin A/C gene creates five known transcript variants, lamin A, lamin C, lamin AΔ10, lamin AΔ50, and lamin C2. The main objective for this
Externí odkaz:
https://doaj.org/article/d1998e6e47684510be0704181c78442f
Autor:
Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity
Externí odkaz:
https://doaj.org/article/13a63de43af34811a3f699cc04d6c57d
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively. Importantly, mutations in nuclear lamins not only participate in lipid disorders bu
Externí odkaz:
https://doaj.org/article/2a4bace251d44b4a8e8eb724c094ddb9
Autor:
Naresh Kumar Manda, Upendarrao Golla, Kishore Sesham, Parth Desai, Shrushti Joshi, Satyam Patel, Sharada Nalla, Susmitha Kondam, Lakhwinder Singh, Deepak Dewansh, Hemalatha Manda, Namita Rokana
Publikováno v:
Cells, Vol 12, Iss 5, p 706 (2023)
The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements,
Externí odkaz:
https://doaj.org/article/97cf3273d7864d2bbc0c589185b96b98
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Olga Lityagina, Gergana Dobreva
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The heart continually senses and responds to mechanical stimuli that balance cardiac structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the different cardiac cell types and converted into signals instructing pr
Externí odkaz:
https://doaj.org/article/9dba56caffda4b959e168edfbc926eb4
Publikováno v:
Nucleus, Vol 11, Iss 1, Pp 237-249 (2020)
The nuclear membranes function as a barrier to separate the cell nucleus from the cytoplasm, but this barrier can be compromised by nuclear membrane ruptures, leading to intermixing of nuclear and cytoplasmic contents. Spontaneous nuclear membrane ru
Externí odkaz:
https://doaj.org/article/4cb55d56a0a941d7b14f8d53e39ae9db
Autor:
Manindra Bera, Kaushik Sengupta
Publikováno v:
Nucleus, Vol 11, Iss 1, Pp 99-110 (2020)
Nuclear lamins form an elastic meshwork underlying the inner nuclear membrane and provide mechanical rigidity to the nucleus and maintain shape. Lamins also maintain chromosome positioning and play important roles in several nuclear processes like re
Externí odkaz:
https://doaj.org/article/ac2901bd281a46a98db0e33949f53240