Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nuala M. Maguire"'
Autor:
Chiara Zanetti, Rafael Di Lazaro Gaspar, Alexander V. Zhdanov, Nuala M. Maguire, Susan A. Joyce, Stuart G. Collins, Anita R. Maguire, Dmitri B. Papkovsky
Publikováno v:
Bioconjugate Chemistry. 33:2161-2169
Autor:
Chiara, Zanetti, Rafael Di Lazaro, Gaspar, Alexander V, Zhdanov, Nuala M, Maguire, Susan A, Joyce, Stuart G, Collins, Anita R, Maguire, Dmitri B, Papkovsky
Publikováno v:
Bioconjugate chemistry. 33(11)
Biological applications of phosphorescent probes for sensing molecular oxygen (O
Publikováno v:
The Journal of Organic Chemistry. 83:10510-10517
The synthesis of guanine α-carboxy nucleoside phosphonate (G-α-CNP) is described. Two routes provide access to racemic G-α-CNP 9, one via base construction and the other utilizing Tsuji-Trost allylic substitution. The latter methodology was also a
Autor:
Nuala M. Maguire, Anita R. Maguire, Simon E. Lawrence, Balakrishna R. Bhogala, U. B. Rao Khandavilli, Abhijeet S. Sinha, Eliška Skořepová
Publikováno v:
Crystal Growth & Design. 18:4571-4577
Cocrystallization studies on Naringenin with 27 coformers have led to the formation of five new solid forms: a piperazinium salt (PIP+-NR-) and four cocrystals with the coformers flavone (FLV), 4-hydroxypyridine (4-HP), anthranilamide (ATA), and 4,4
Autor:
Eddy Arnold, Jan Balzarini, Jubi John, Anita R. Maguire, Wim Dehaen, Nuala M. Maguire, Alan Ford, Kalyan Das
Publikováno v:
Future medicinal chemistry. 11(2)
Acyclic nucleoside phosphonates represent a well-defined class of clinically used nucleoside analogs. All acyclic nucleoside phosphonates need intracellular phosphorylation before they can bind viral DNA polymerases. Recently, a novel class of alpha-
Autor:
Johan Vande Voorde, Jubi John, Eddy Arnold, Nuala M. Maguire, Jean A. Bernatchez, Jan Balzarini, Alan Ford, Sandra Liekens, Sergio E. Martinez, Niki Mullins, Anita R. Maguire, Kalyan Das, Marianne Ngure, Matthias Götte, Lieve Naesens, Wim Dehaen, Sarah Keane, Youngju Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 112:3475-3480
Polymerases have a structurally highly conserved negatively charged amino acid motif that is strictly required for Mg(2+) cation-dependent catalytic incorporation of (d)NTP nucleotides into nucleic acids. Based on these characteristics, a nucleoside
Autor:
Alan Ford, Sarah Keane, Nicholas D. Mullins, Anita R. Maguire, Thibaut Legigan, Jan Balzarini, Nuala M. Maguire
Publikováno v:
The Journal of Organic Chemistry. 80:2479-2493
The synthesis of the first series of a new class of nucleoside phosphonate analogues is described. Addition of a carboxyl group at the α position of carbocyclic nucleoside phosphonate analogues leads to a novel class of potent HIV reverse transcript
Autor:
Anita R. Maguire, Sandra Liekens, Paul E. Boehmer, Eddy Arnold, Jan Balzarini, Matthias Götte, Michael Menni, Lizette van Berckelaer, Alan Ford, Nuala M. Maguire, Kalyan Das
Publikováno v:
Biochemical pharmacology. 136
α-Carboxy nucleoside phosphonates (α-CNPs) are modified nucleotides that represent a novel class of nucleotide-competing reverse transcriptase (RT) inhibitors (NcRTIs). They were designed to act directly against HIV-1 RT without the need for prior
Autor:
Kalyan Das, Jan Balzarini, Nuala M. Maguire, Nicholas D. Mullins, Alan Ford, Anita R. Maguire, Edward Arnold
Publikováno v:
Organicbiomolecular chemistry. 14(8)
As α-carboxy nucleoside phosphonates (α-CNPs) have demonstrated a novel mode of action of HIV-1 reverse transcriptase inhibition, structurally related derivatives were synthesized, namely the malonate 2, the unsaturated and saturated bisphosphonate
Autor:
Simon E. Lawrence, Michael E. Foreman, Anita R. Maguire, Nuala M. Maguire, Bridget N. Hogan, Åke C. Rasmuson, Curtis J. Elcoate, Denise M. Croker, Benjamin K. Hodnett
Publikováno v:
Crystal Growth & Design. 12:869-875
A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3: