Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Nuala J, Meyer"'
Autor:
L. K. Metthew Lam, Emily Oatman, Kaitlyn A. Eckart, Nathan J. Klingensmith, Emily Flowers, Layal Sayegh, Julia Yuen, Rebecca L. Clements, Nuala J. Meyer, Kellie A. Jurado, Andrew E. Vaughan, Stephanie C. Eisenbarth, Nilam S. Mangalmurti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Red blood cells (RBCs) express the nucleic acid-binding toll-like receptor 9 (TLR9) and bind CpG-containing DNA. However, whether human RBCs express other nucleic acid-binding TLRs is unknown. Here we show that human RBCs express the RNA sen
Externí odkaz:
https://doaj.org/article/afd7120448ec4e1f9581ca8408fd6e8a
Autor:
Gan Zhao, Maria E. Gentile, Lulu Xue, Christopher V. Cosgriff, Aaron I. Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P. Holcomb, Maria C. Basal, Kathleen M. Stewart, Joseph D. Planer, Edward Cantu, Jason D. Christie, Maria M. Crespo, Michael J. Mitchell, Nuala J. Meyer, Andrew E. Vaughan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Inflammation induced by lung infection is a double-edged sword, moderating both anti-viral and immune pathogenesis effects; the mechanism of the latter is not fully understood. Previous studies suggest the vasculature is involved in tissue i
Externí odkaz:
https://doaj.org/article/298e4f96eba74047b28b7e392be57e41
Autor:
Joe Bean, Leticia Kuri-Cervantes, Michael Pennella, Michael R. Betts, Nuala J. Meyer, Wail M. Hassan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-28 (2023)
Abstract The novel coronavirus pandemic continues to cause significant morbidity and mortality around the world. Diverse clinical presentations prompted numerous attempts to predict disease severity to improve care and patient outcomes. Equally impor
Externí odkaz:
https://doaj.org/article/f88aa008d52d4790bc0be4aace6049b5
Autor:
Robert B. Lindell, Nuala J. Meyer
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-7 (2023)
Abstract This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2023 . Further information
Externí odkaz:
https://doaj.org/article/3d0e4a6dba6a4d47a47718c708733353
Autor:
Christopher W. Seymour, MD, MSc, Kelly Lynn Urbanek, MS, Anna Nakayama, Jason N. Kennedy, MS, Rachel Powell, MD, Renã A.S. Robinson, PhD, Kathryn L. Kapp, BS, Timothy R. Billiar, MD, Yoram Vodovotz, PhD, Stacy L. Gelhaus, PhD, Vaughn S. Cooper, PhD, Lu Tang, PhD, Flo Mayr, MD, Katherine M. Reitz, MD, MSc, Christopher Horvat, MD, Nuala J. Meyer, MD, MS, Robert P. Dickson, Derek Angus, MD, Octavia Peck Palmer, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 11, p e0974 (2023)
BACKGROUND:. Sepsis is a common and deadly syndrome, accounting for more than 11 million deaths annually. To mature a deeper understanding of the host and pathogen mechanisms contributing to poor outcomes in sepsis, and thereby possibly inform new th
Externí odkaz:
https://doaj.org/article/7ed111b6ecb34b9ea933120437ef9700
Autor:
Hu Meng, Arjun Sengupta, Emanuela Ricciotti, Antonijo Mrčela, Divij Mathew, Liudmila L. Mazaleuskaya, Soumita Ghosh, Thomas G. Brooks, Alexandra P. Turner, Alessa Soares Schanoski, Nicholas F. Lahens, Ai Wen Tan, Ashley Woolfork, Greg Grant, Katalin Susztak, Andrew G. Letizia, Stuart C. Sealfon, E. John Wherry, Krzysztof Laudanski, Aalim M. Weljie, Nuala J. Meyer, Garret A. FitzGerald
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Abstract Background Lipids may influence cellular penetrance by viral pathogens and the immune response that they evoke. We deeply phenotyped the lipidomic response to SARs‐CoV‐2 and compared that with infection with other pathogens in patients a
Externí odkaz:
https://doaj.org/article/810742408e2d4ead95afe8bcbe4b3a81
Autor:
Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras, Elena Espinosa, Arturo Muriel, Eduardo Tamayo, María M. Martin, Leonardo Lorente, David Domínguez, Abelardo García de Lorenzo, Heather M. Giannini, John P. Reilly, Tiffanie K. Jones, José M. Añón, Marina Soro, Ángel Carracedo, Louise V. Wain, Nuala J. Meyer, Jesús Villar, Carlos Flores, the Genetics of Sepsis (GEN-SEP) Network
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-10 (2022)
Abstract Background Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene variants associated wi
Externí odkaz:
https://doaj.org/article/6a41f741af084c4dab8e4ca22baabbb6
Autor:
Philip Yang, MD, MSc, Neal W. Dickert, MD, PhD, Angela Haczku, MD, PhD, Christine Spainhour, RN, CCRC, Sara C. Auld, MD, MSc, the I-SPY COVID Consortium, Neil R. Aggarwal, MD, MHSc, Timothy Albertson, MD, Sara Auld, MD, Jeremy R. Beitler, MD, MPH, Paul Berger, DO, Ellen L. Burnham, MD, Carolyn S. Calfee, MD, MAS, Nathan Cobb, MD, Alessio Crippa, PhD, Andrea Discacciati, PhD, Martin Eklund, PhD, Laura Esserman, MD, MBA, D. Clark Files, MD, Eliot Friedman, MD, Sheetal Gandotra, MD, Kashif Khan, MD, Jonathan Koff, MD, Santhi Kumar, MD, Kathleen D. Liu, MD, PhD, Thomas R. Martin, MD, Michael A. Matthay, MD, Nuala J. Meyer, MD, Timothy Obermiller, MD, MS, Philip Robinson, MD, Derek Russell, MD, Karl Thomas, MD, Se Fum Wong, MD, Richard G. Wunderink, MD, Mark M. Wurfel, PhD, MD, Albert Yen, MD, Fady A. Youssef, MD, Anita Darmanian, MD, Amy L. Dzierba, PharmD, Ivan Garcia, RRT, Katarzyna Gosek, PharmD, Purnema Madahar, MD, MS, Aaron M. Mittel, MD, Justin Muir, PharmD, Amanda Roden, MD, John Schicchi, MD, Alexis L. Serra, MD, MPH, Romina Wahab, MD, Kevin W. Gibbs, MD, Leigha Landreth, RN, Mary LaRose, RN, Lisa Parks, RN, Adina Wynn, MPH, CCRP, Caroline A. G. Ittner, PhD, Nilam S. Mangalmurti, MD, John P. Reilly, MD, MS, Donna Harris, BSN, Abhishek Methukupally, MBBS, Siddharth Patel, MBBS, MPH, Lindsie Boerger, BA, John Kazianis, MD, Carrie Higgins, Jeff McKeehan, MS, Brian Daniel, RCP, RRT, Scott Fields, PharmD, James Hurst-Hopf, MS, Alejandra Jauregui, BA, Lamorna Brown Swigart, PhD, Daniel Belvins, CCRP, Catherine Nguyen, MD, Alexis Suarez, MS, Maged A. Tanios, MD, Farjad Sarafian, MD, Usman Shah, MD, Max Adelman, MD, MSc, Christina Creel-Bulos, MD, Joshua Detelich, MD, Gavin Harris, MD, Katherine Nugent, MD, Philip Yang, MD, Erin Hardy, Richart Harper, MD, Brian Morrissey, MD, Christian Sandrock, MD, MPH, G. R. Scott Budinger, MD, Helen K. Donnelly, RN, BSN, Benjamin D. Singer, MD, Ari Moskowitz, MD, Melissa Coleman, MD, Joseph Levitt, MD, Ruixiao Lu, PhD, Paul Henderson, PhD, Adam Asare, PhD, Imogene Dunn, PhD, Alejandro Botello Barragan
Publikováno v:
Critical Care Explorations, Vol 5, Iss 6, p e0930 (2023)
OBJECTIVES:. To analyze the temporal trend in enrollment rates in a COVID-19 platform trial during the first three waves of the pandemic in the United States. DESIGN:. Secondary analysis of data from the I-SPY COVID randomized controlled trial (RCT).
Externí odkaz:
https://doaj.org/article/7af4c25ca81249e2a0432daa16bb510e
Autor:
D. Clark Files, Neil Aggarwal, Timothy Albertson, Sara Auld, Jeremy R. Beitler, Paul Berger, Ellen L. Burnham, Carolyn S. Calfee, Nathan Cobb, Alessio Crippa, Andrea Discacciati, Martin Eklund, Laura Esserman, Eliot Friedman, Sheetal Gandotra, Kashif Khan, Jonathan Koff, Santhi Kumar, Kathleen D. Liu, Thomas R. Martin, Michael A. Matthay, Nuala J. Meyer, Timothy Obermiller, Philip Robinson, Derek Russell, Karl Thomas, Se Fum Wong, Richard G. Wunderink, Mark M. Wurfel, Albert Yen, Fady A. Youssef, Anita Darmanian, Amy L. Dzierba, Ivan Garcia, Katarzyna Gosek, Purnema Madahar, Aaron M. Mittel, Justin Muir, Amanda Rosen, John Schicchi, Alexis L. Serra, Romina Wahab, Kevin W. Gibbs, Leigha Landreth, Mary LaRose, Lisa Parks, Adina Wynn, Caroline A.G. Ittner, Nilman S. Mangalmurti, John P. Reilly, Donna Harris, Abhishek Methukupally, Siddharth Patel, Lindsie Boerger, John Kazianis, Carrie Higgins, Jeff McKeehan, Brian Daniel, Scott Fields, James Hurst-Hopf, Alejandra Jauregui, Lamorna Brown Swigart, Daniel Blevins, Catherine Nguyen, Alexis Suarez, Maged A. Tanios, Farjad Sarafian, Usman Shah, Max Adelman, Christina Creel-Bulos, Joshua Detelich, Gavin Harris, Katherine Nugent, Christina Spainhour, Philip Yang, Angela Haczku, Erin Hardy, Richart Harper, Brian Morrissey, Christian Sandrock, G. R. Scott Budinger, Helen K. Donnelly, Benjamin D. Singer, Ari Moskowitz, Melissa Coleman, Joseph Levitt, Ruixiao Lu, Paul Henderson, Adam Asare, Imogene Dunn, Alejandro Botello Barragan
Publikováno v:
EClinicalMedicine, Vol 58, Iss , Pp 101889- (2023)
Summary: Background: An urgent need exists to rapidly screen potential therapeutics for severe COVID-19 or other emerging pathogens associated with high morbidity and mortality. Methods: Using an adaptive platform design created to rapidly evaluate i
Externí odkaz:
https://doaj.org/article/455f6804c6664df29b7f69d1279558b0
Autor:
Christopher H Gu, Layla A Khatib, Ayannah S Fitzgerald, Jevon Graham-Wooten, Caroline A Ittner, Scott Sherrill-Mix, YuChung Chuang, Laurel J Glaser, Nuala J Meyer, Frederic D Bushman, Ronald G Collman
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0289923 (2023)
BackgroundThe gut microbiome is believed to contribute to bloodstream infection (BSI) via translocation of dominant gut bacteria in vulnerable patient populations. However, conclusively linking gut and blood organisms requires stringent approaches to
Externí odkaz:
https://doaj.org/article/ae39e855920246ee9b732456a41a8b9f