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pro vyhledávání: '"Nuala Daw"'
Autor:
Nisha, Padmanabhan, Katerina, Menelaou, Jiali, Gao, Alexander, Anderson, Georgina E T, Blake, Tanya, Li, B Nuala, Daw, Erica D, Watson
Publikováno v:
The Journal of Physiology
Key points Folate (folic acid) deficiency and mutations in folate‐related genes in humans result in megaloblastic anaemia.Folate metabolism, which requires the enzyme methionine synthase reductase (MTRR), is necessary for DNA synthesis and the tran
Publikováno v:
The Journal of General Physiology
The Ca(2+)-sensitive K(+) channel of human red blood cells (RBCs) (Gardos channel, hIK1, hSK4) was implicated in the progressive densification of RBCs during normal senescence and in the mechanism of sickle cell dehydration. Saturating RBC Ca(2+) loa
Publikováno v:
Journal of Laboratory and Clinical Medicine. 137:199-207
No specific inhibitors of the plasma membrane Ca2+ pump have been found to date, limiting research on the particular contribution of this pump to the Ca2+ homeostasis of animal cells. The search for Ca2+ pump inhibitors may have been hampered by the
Autor:
Deisy Perdomo, Zipora Etzion, Teresa Tiffert, Robert M. Bookchin, Lynn Macdonald, Virgilio L. Lew, Nuala Daw
Publikováno v:
Blood. 105(1)
The Ca2+-activated K+ channels of human red blood cells (RBCs) (Gardos channels, hIK1, hSK4) can mediate rapid cell dehydration, of particular relevance to the pathophysiology of sickle cell disease. Previous investigations gave widely discrepant est
Publikováno v:
Blood. 102(12)
The plasma membrane calcium pump (PMCA) is the only active Ca2+ transporter in human red blood cells (RBCs). Previous measurements of maximal Ca2+ extrusion rates (Vmax) reported only mean values in the RBC population. Despite early evidence for diff
Publikováno v:
Blood. 108:1243-1243
We described earlier a small fraction of sickle (SS) and normal RBC that resisted dehydration when K+-permeabilized in low-K+ media with valinomycin (val) or Ca2+ + [A23187][1] (“valres” and “calres”, together “CVres”) (Bookchin et al, PN
Publikováno v:
Blood. 106:1670-1670
We recently demonstrated that the activity of the PMCA varies greatly among the RBCs in a normal blood sample (Lew et al., Blood102:4206,2003). To test the possibility that these variations might be related to cell age, we designed a new experimental