NTR1 is involved in heat stress tolerance through mediating expression regulation and alternative splicing of heat stress genes in Arabidopsis

Autor: Lei He, Qi Wu, Ye Jin, Ye Fan, Huazhong Shi, Yizhong Wang, Wannian Yang

Publikováno v: Frontiers in Plant Science, Vol 13 (2023)

As a common adverse environmental factor, heat stress (HS) not only drastically changes the plant transcriptome at the transcription level but also increases alternative splicing (AS), especially intron retention (IR) events. However, the exact mecha

Externí odkaz: https://doaj.org/article/2a666be536974e538cf432d677f77246

Effect of neurotensin on cultured mouse preimplantation embryos

Autor: Yuki HIRADATE, Kenshiro HARA, Kentaro TANEMURA

Publikováno v: The Journal of Reproduction and Development, Vol 66, Iss 5, Pp 421-425 (2020)

Previously, we revealed that neurotensin (NTS) derived from the oviduct and uterus can function during fertilization. However, little is known about NTS actions on the pre-implantation embryo after fertilization. Here, we found that pro-Nts mRNA is e

Externí odkaz: https://doaj.org/article/1e648bdc2f2245389282da3a43b8e9b0

Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner

Autor: Heidi L. Weiss, Stephanie A. Rock, Tianyan Gao, Chi Wang, Jing Li, B. Mark Evers, Yuanyuan Wu, Kai Jiang, Yajuan Liu, Jianhang Jia

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 501-516 (2022)

Background & Aims: Intestinal stem cells (ISCs) are sensitive to dietary alterations and nutrient availability. Neurotensin (NT), a gut peptide localized predominantly to the small bowel and released by fat ingestion, stimulates the growth of intesti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b829f42bc7cc4f64577e8588c520793
https://doi.org/10.1016/j.jcmgh.2021.09.006

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New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

Autor: Pedron, Julien, Boudot, Clotilde, Brossas, Jean-Yves, Pinault, Emilie, Bourgeade-Delmas, Sandra, Sournia-Saquet, Alix, Boutet-Robinet, Elisa, Destere, Alexandre, Tronnet, Antoine, Bergé, Justine, Bonduelle, Colin, Deraeve, Céline, Pratviel, Geneviève, Stigliani, Jean-Luc, Paris, Luc, Mazier, Dominique, Corvaisier, Sophie, Since, Marc, Malzert-Fréon, Aurélie, Malzert-Freón, Aureĺie, Wyllie, Susan, Milne, Rachel, Fairlamb, Alan, Valentin, Alexis, Courtioux, Bertrand, Verhaeghe, Pierre

Publikováno v: ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, 2020, 11 (4), pp.464-472. ⟨10.1021/acsmedchemlett.9b00566⟩
ACS Medicinal Chemistry Letters, American Chemical Society, 2020, 11 (4), pp.464-472. ⟨10.1021/acsmedchemlett.9b00566⟩
ACS Medicinal Chemistry Letters, American Chemical Society, 2020, ⟨10.1021/acsmedchemlett.9b00566⟩

International audience; An antikinetoplastid pharmacomodulation study was conducted at position 6 of the 8-nitroquinolin-2(1H)-one pharmacophore. Fifteen new derivatives were synthesized and evaluated in vitro against L. infantum, T. brucei brucei, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9a1059a2d3cb39294182acf9b81e37
https://unilim.hal.science/hal-02476867/document