Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ntlotlang, Mokgautsi"'
Autor:
Ntlotlang Mokgautsi, Alexander TH Wu, Sheng-Yao Cheng, Jih-Chin Lee, Thomashire Anita George, Jia-Hong Chen
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 3, Pp 105561- (2024)
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive cancer affecting over half a million people worldwide each year. Although recent FDA-approved treatments, like cetuximab, have shown promise, the five-year survival rate remains bel
Externí odkaz:
https://doaj.org/article/b3ee116482564b0baee3bfe0fe3f4f50
Autor:
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T.H Wu, Hsu-Shan Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 1, Pp 105423- (2024)
Tetraheterocyclic compounds, derived from natural sources and contemporary pharmaceuticals, have shown promise as multitarget therapeutic agents. However, their mechanisms of action remain partially understood. In this study, we synthesized a series
Externí odkaz:
https://doaj.org/article/47e48b334a9b414aa185b8989a82291c
Publikováno v:
Cells, Vol 13, Iss 8, p 700 (2024)
Cervical cancer is a major cause of death in women despite the advancement of current treatment modalities. The conventional therapeutic agent, cisplatin (CCDP), is the standard treatment for CC; however, resistance often develops due to the cancer
Externí odkaz:
https://doaj.org/article/fe46af46e2614d3fb9dd9c43546c8128
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 2011 (2023)
Tumor angiogenesis and lymphangiogenesis pathways have been identified as important therapeutic targets in non-small cell lung cancer (NSCLC). Bevacizumab, which is a monoclonal antibody, was the initial inhibitor of angiogenesis and lymphangiogenesi
Externí odkaz:
https://doaj.org/article/b1cb7da7b67a44ad8b76a965b87aedc3
Autor:
Yi-Fong Chen, Bashir Lawal, Li-Jiau Huang, Sheng-Chu Kuo, Maryam Rachmawati Sumitra, Ntlotlang Mokgautsi, Hung-Yun Lin, Hsu-Shan Huang
Publikováno v:
Molecules, Vol 28, Iss 2, p 555 (2023)
Our previous study found that 2-phenyl-4-quinolone (2-PQ) derivatives are antimitotic agents, and we adopted the drug design concept of scaffold hopping to replace the 2-aromatic ring of 2-PQs with a 4-aromatic ring, representing 4-phenyl-2-quinolone
Externí odkaz:
https://doaj.org/article/1ed60b03c4ea474186cda1f3f11edc1b
Autor:
Ntlotlang Mokgautsi, Yu-Cheng Kuo, Yan-Jiun Huang, Chien-Hsin Chen, Debabrata Mukhopadhyay, Alexander T. H. Wu, Hsu-Shan Huang
Publikováno v:
Cells, Vol 12, Iss 2, p 266 (2023)
Colorectal cancer (CRC) is one of the most common cancers, and it frequently metastasizes to the liver and lymph nodes. Despite major advances in treatment modalities, CRC remains a poorly characterized biological malignancy, with high reported cases
Externí odkaz:
https://doaj.org/article/9a61204bb5d54058907b3edabbb27900
Autor:
Ntlotlang Mokgautsi, Yu-Cheng Kuo, Chien-Hsin Chen, Yan-Jiun Huang, Alexander T. H. Wu, Hsu-Shan Huang
Publikováno v:
Cells, Vol 12, Iss 2, p 340 (2023)
Colorectal cancer (CRC) is one of the most prevalent malignant tumors, and it contributes to high numbers of deaths globally. Although advances in understanding CRC molecular mechanisms have shed significant light on its pathogenicity, current treatm
Externí odkaz:
https://doaj.org/article/1b912d32059e4380b5201e3eb46e230b
Autor:
Bashir Lawal, Ching-Yu Lee, Ntlotlang Mokgautsi, Maryam Rachmawati Sumitra, Harshita Khedkar, Alexander T.H. Wu, Hsu-Shan Huang
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundThe application of computational and multi-omics approaches has aided our understanding of carcinogenesis and the development of therapeutic strategies. NSC765598 is a novel small molecule derivative of salicylanilide. This study aims to in
Externí odkaz:
https://doaj.org/article/4e316418df5b40258273fc203b8b814b
Autor:
Wai-Hung Leung, Jing-Wen Shih, Jian-Syun Chen, Ntlotlang Mokgautsi, Po-Li Wei, Yan-Jiun Huang
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 377 (2022)
Approximately 25% of colorectal cancer (CRC) patients will develop metastatic (m)CRC despite treatment interventions. In this setting, tumor cells are attracted to the epidermal growth factor receptor (EGFR) oncogene. Kirsten rat sarcoma (RAS) 2 vira
Externí odkaz:
https://doaj.org/article/bef6fa7010a7449c972675517530e165
Autor:
Alexander T. H. Wu, Hsu-Shan Huang, Ya-Ting Wen, Bashir Lawal, Ntlotlang Mokgautsi, Thanh-Tuan Huynh, Michael Hsiao, Li Wei
Publikováno v:
Cells, Vol 10, Iss 9, p 2391 (2021)
Glioblastoma (GBM) is one of the most aggressive brain malignancies with high incidences of developing treatment resistance, resulting in poor prognoses. Glioma stem cell (GSC)-derived exosomes are important players that contribute to GBM tumorigenes
Externí odkaz:
https://doaj.org/article/e6a3a5ed9d5343ee87aaa867eb8dfc66