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Long-term social isolation inhibits autophagy activation, induces postsynaptic dysfunctions and impairs spatial memory.

Autor: Wang B; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, Dalian Medical University, Dalian, Liaoning, China. Electronic address: wb101900@163.com., Wu Q; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, Dalian Medical University, Dalian, Liaoning, China., Lei L; Technology Centre of Target-based Nature Products for Prevention and Treatment of Ageing-related Neurodegeneration, Dalian Medical University, Dalian, Liaoning, China., Sun H; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, Dalian Medical University, Dalian, Liaoning, China., Michael N; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, Dalian Medical University, Dalian, Liaoning, China., Zhang X; Technology Centre of Target-based Nature Products for Prevention and Treatment of Ageing-related Neurodegeneration, Dalian Medical University, Dalian, Liaoning, China., Wang Y; Department of Cardiology, Institute of Heart and Vessel Diseases of Dalian Medical University, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning, China., Zhang Y; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, Dalian Medical University, Dalian, Liaoning, China., Ge B; Technology Centre of Target-based Nature Products for Prevention and Treatment of Ageing-related Neurodegeneration, Dalian Medical University, Dalian, Liaoning, China., Wu X; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, Dalian Medical University, Dalian, Liaoning, China., Wang Y; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning, China., Xin Y; Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning, China. Electronic address: jimxin@hotmail.com., Zhao J; Technology Centre of Target-based Nature Products for Prevention and Treatment of Ageing-related Neurodegeneration, Dalian Medical University, Dalian, Liaoning, China. Electronic address: zhaoj@dmu.edu.cn., Li S; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, Dalian Medical University, Dalian, Liaoning, China. Electronic address: lishao89@dmu.edu.cn.

Publikováno v: Experimental neurology [Exp Neurol] 2019 Jan; Vol. 311, pp. 213-224. Date of Electronic Publication: 2018 Sep 13.