Zobrazeno 1 - 10
of 961
pro vyhledávání: '"Ns5b polymerase"'
Autor:
Li, Jie Jack, author
Publikováno v:
Conquest of Invisible Enemies : A Human History of Antiviral Drugs, 2022.
Externí odkaz:
https://doi.org/10.1093/oso/9780197609859.003.0003
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Background Hepatitis C virus (HCV) is considered a worldwide health problem since it affects over 3% of the population and causes 300,000 fatalities per year. Chronic infection causes high morbidity and mortality in patients, leading to live
Externí odkaz:
https://doaj.org/article/796b31e718d44ea0aa21a2287fafd762
Akademický článek
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Akademický článek
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Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2761-2774 (2021)
GS-9669 is a non-nucleos(t)ide inhibitor (NNI) binding to the thumb site II of the Hepatitis C virus (HCV) NS5B polymerase and has advanced into phase II trials. To clarify the drug resistance mechanisms of GS-9669 caused by M423T/I/V, L419M, R422K,
Externí odkaz:
https://doaj.org/article/fadf596756f349f8b259ecc2cc70a92b
Autor:
Sabrina Bagaglio, Caterina Uberti-Foppa, Alessandro Olgiati, Emanuela Messina, Hamid Hasson, Camilla Ferri, Giulia Morsica
Publikováno v:
Virology Journal, Vol 15, Iss 1, Pp 1-7 (2018)
Abstract Background We evaluated the frequency of naturally occurring resistance associated substitutions (RASs) and their characteristic of polymorphic or non-polymorphic amino acid change to direct acting antivirals (DAAs) in NS5b HCV subtypes 1a a
Externí odkaz:
https://doaj.org/article/ae0393b2d54c4670ae1ba9cc569af5c3
Publikováno v:
The Journal of Engineering and Exact Sciences, Vol 4, Iss 2, Pp 0265-0275 (2018)
A combined three-dimensional quantitative structure-activity relationship (QSAR) modeling and molecular docking studies were carried out on the 64 indole derivatives and was accomplished to profoundly understand the structure-activity correlation of
Externí odkaz:
https://doaj.org/article/d9faa4105cd54699a74d6b7bc424bc31
Akademický článek
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Publikováno v:
Letters in Drug Design & Discovery. 19:54-68
Background: In recent years, the number of people infected with the hepatitis C virus (HCV) is increasing rapidly. This has become a major threat to global health, therefore, new anti- HCV drugs are urgently needed. HCV NS5B polymerase is an RNA-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1a7c971430fbb11c5910632f543707b
https://doi.org/10.2174/1570180818666210804125607
https://doi.org/10.2174/1570180818666210804125607
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2761-2774 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2761-2774 (2021)
Graphical abstract
GS-9669 is a non-nucleos(t)ide inhibitor (NNI) binding to the thumb site II of the Hepatitis C virus (HCV) NS5B polymerase and has advanced into phase II trials. To clarify the drug resistance mechanisms of GS-9669 caused by M
GS-9669 is a non-nucleos(t)ide inhibitor (NNI) binding to the thumb site II of the Hepatitis C virus (HCV) NS5B polymerase and has advanced into phase II trials. To clarify the drug resistance mechanisms of GS-9669 caused by M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385aee917fa2ed19301449c57d574ec7
http://europepmc.org/articles/PMC8134009
http://europepmc.org/articles/PMC8134009