Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nrupa Borkar"'
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 6, Pp 507-517 (2018)
Parkinson's disease (PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has a similar chemical structure as
Externí odkaz:
https://doaj.org/article/53e04430893b45ce95f35101a19d6852
Autor:
Anas Al-Khawaja, Stine B. Vogensen, Hans Bräuner-Osborne, Jonas Skovgaard-Petersen, Rasmus P. Clausen, Stefanie Kickinger, Petrine Wellendorph, Arne Schousboe, Rebekka Löffler, Karsten K. Madsen, Gerhard F. Ecker, Emil Rosenthal, Lars N. Jorgensen, Nrupa Borkar
Publikováno v:
Journal of Medicinal Chemistry. 60:8834-8846
N-(1-Benzyl-4-piperidinyl)-2,4-dichlorobenzamide 5 (BPDBA) is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1). We here report the synthesis and structure-activity relationship of 71 analogues. We identify 26m as a more soluble 2,4
Publikováno v:
International Journal of Pharmaceutics. 513:211-217
In the present study, the differences in oral absorption of apomorphine and its diester prodrugs and the effect of lipid-based formulations on the absorption of apomorphine or its prodrugs were investigated. Apomorphine, dilauroyl apomorphine (DLA) a
Autor:
Nrupa Borkar, Pedro L. Esquinas, Peter Bønløkke, Anette Müllertz, Stoyan Karagiozov, Cristina Rodríguez-Rodríguez, Katayoun Saatchi, Urs O. Häfeli, Thomas Rades, Jakob Plum, Thuy Tran, Zeynab Nosrati, Sophie Strindberg
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 317
Using lipid-based drug delivery systems (LbDDS) is an efficient strategy to enhance the low oral bioavailability of poorly water-soluble drugs. Here the oral absorption of fenofibrate (FF) from LbDDS in rats was investigated in pharmacokinetic, in vi
Publikováno v:
Borkar, N, Mu, H & Holm, R 2018, ' Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease ', Asian Journal of Pharmaceutical Sciences, vol. 13, no. 6, pp. 507-517 . https://doi.org/10.1016/j.ajps.2017.11.004
Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 6, Pp 507-517 (2018)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 6, Pp 507-517 (2018)
Asian Journal of Pharmaceutical Sciences
Graphical abstract Image, graphical abstract
Parkinson's disease (PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss
Parkinson's disease (PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4126fc9f4997948bd56b6cacef3ba2a6
https://curis.ku.dk/ws/files/216310712/1_s2.0_S1818087617306189_main.pdf
https://curis.ku.dk/ws/files/216310712/1_s2.0_S1818087617306189_main.pdf
Autor:
Anders E. Håkansson, Zhizhong Chen, Mingshi Yang, Nrupa Borkar, René Holm, Lasse Saaby, Anette Müllertz, Christian Schönbeck, Huiling Mu
Publikováno v:
International Journal of Pharmaceutics. 509:499-506
Oral delivery of apomorphine via prodrug principle may be a potential treatment for Parkinson's disease. The purpose of this study was to investigate the transport and stability of apomorphine and its esters across Caco-2 cell monolayer and their aff
Publikováno v:
The Journal of pharmacy and pharmacology. 69(9)
Objectives Apomorphine is used to symptomatically treat Parkinson's disease (PD). Oral delivery of apomorphine is generally limited by its short plasma half-life and a hepatic first-pass metabolism. This study was aimed at evaluating the behavioural
Autor:
Rasmus P. Clausen, Lars N. Jorgensen, Andreas Jurik, Emiliano Rosatelli, Stine B. Vogensen, Birgitte Nielsen, Arne Schousboe, Karsten K. Madsen, Nrupa Borkar, Gerhard F. Ecker
Publikováno v:
Bioorganicmedicinal chemistry. 23(10)
A series of β-amino acids with lipophilic diaromatic side chain was synthesized and characterized pharmacologically on mouse γ-amino butyric acid (GABA) transporter subtypes mGAT1-4 in order to investigate structure activity relationships (SAR) for
Autor:
Nrupa Borkar, Mingshi Yang, René Holm, Boyang Li, Anette Müllertz, Huiling Mu, Anders E. Håkansson
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 89
Apomorphine, a subcutaneously administered drug for Parkinson’s disease with short half-life requires frequent administration leading to patient non-compliance. This study aimed at synthesising and purifying lipophilic diesters of apomorphine, and
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 51
Lipid matrix particles (LMP) may be used as better carriers for poorly water-soluble drugs than liquid lipid carriers because of reduced drug mobilization in the formulations. However, the digestion process of solid lipid particles and their effect o