Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Nrf2, nuclear factor erythroid 2–related factor 2"'
Autor:
Cedric O. Renaud, Panos G. Ziros, Dionysios V. Chartoumpekis, Massimo Bongiovanni, Gerasimos P. Sykiotis
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The Keap1/Nrf2 pathway is a key mediator of general redox and tissue-specific homeostasis. It also exerts a dual role in cancer, by preventing cell transformation of normal cells but promoting aggressiveness, and drug resistance of malignant ones. Al
Externí odkaz:
https://doaj.org/article/868e5804eeca46b2b28347b866639367
Autor:
Santos, María Villa-Morales, Laura Pérez-Gómez, Eduardo Pérez-Gómez, Pilar López-Nieva, Pablo Fernández-Navarro, Javier
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10350
The standard-of-care treatment of T-cell acute lymphoblastic leukaemia (T-ALL) with chemotherapy usually achieves reasonable rates of initial complete response. However, patients who relapse or do not respond to conventional therapy show dismal outco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::0e04ae550a5f806850fc930191639a10
Autor:
Christina Thanas, Panos G. Ziros, Dionysios V. Chartoumpekis, Cédric O. Renaud, Gerasimos P. Sykiotis
Publikováno v:
Antioxidants, Vol 9, Iss 11, p 1082 (2020)
The thyroid gland has a special relationship with oxidative stress. On the one hand, like all other tissues, it must defend itself against reactive oxygen species (ROS). On the other hand, unlike most other tissues, it must also produce reactive oxyg
Externí odkaz:
https://doaj.org/article/e1f88ed9dc7e45f9903f42f73222199b
Autor:
Wenbin Huang, Lei Cai, Guolin He, Liang Zhao, Yishi Lu, Mingxin Pan, Donghui Zhang, Yuan Cheng, Hangyu Liao, Weimei Huang, Yujun Tang, Liuran Li, Kunling Chen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1227-1239 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), and reducing sorafenib resistance is an important issue to be resolved for the clinical treatment of HCC. In the current study, we identified that ABCC5 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7546a05995e276bc0a627d79310110
http://www.sciencedirect.com/science/article/pii/S1476558621000919
http://www.sciencedirect.com/science/article/pii/S1476558621000919
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020
https://doi.org/10.1016/j.apsb.2020.12.020
Akademický článek
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Publikováno v:
Regenerative Therapy, Vol 17, Iss, Pp 8-12 (2021)
Regenerative Therapy
Regenerative Therapy
Recent studies have revealed that cancer stem cells (CSCs) undergo metabolic alterations that differentiate them from non-CSCs. Inhibition of specific metabolic pathways in CSCs has been conducted to eliminate the CSC population in many types of canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6e792e0488411d444bcff6479bbf43
https://doi.org/10.1016/j.reth.2021.01.005
https://doi.org/10.1016/j.reth.2021.01.005
Autor:
Ding Yuan, Chengfu Yuan, Liyue Gai, Yan Gao, Yue Shi, Yumin He, Chaoqi Liu, Xuelian Wu, Gang Zhou, Changcheng Zhang
Publikováno v:
Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 3, Pp 408-419 (2021)
Journal of Ginseng Research, Vol 45, Iss 3, Pp 408-419 (2021)
Background: The decreased renal function is known to be associated with biological aging, of which the main pathological features are chronic inflammation and renal interstitial fibrosis. In previous studies, we reported that total saponins from Pana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92217cdd10e9c934df2aec2229c0abbf
https://doi.org/10.1016/j.jgr.2020.08.005
https://doi.org/10.1016/j.jgr.2020.08.005
Autor:
Maged S. Abdel-Kader, Gamal A. Soliman, Ahmed I. Foudah, Abdulaziz S. Saeedan, Reham M. Abd-Elsalam, Hanan A. Ogaly, Rehab F. Abdel-Rahman
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 3, Pp 1713-1722 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Graphical abstract
Diabetes mellitus is a well-known danger element for the progression of male reproductive dysfunctions. Available evidence supports oxidative stress to be the underlying mechanism for the manifestation of testicular dysfunctio
Diabetes mellitus is a well-known danger element for the progression of male reproductive dysfunctions. Available evidence supports oxidative stress to be the underlying mechanism for the manifestation of testicular dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddef32683deddd75fdedb6dda4e14ed
http://www.sciencedirect.com/science/article/pii/S1319562X20306689
http://www.sciencedirect.com/science/article/pii/S1319562X20306689
Autor:
Chang Jia, Jian Xiao, Abdullah Al Mamun, Fahad Munir, Ilma Monalisa, Kailiang Zhou, Yanqing Wu
Publikováno v:
Journal of Advanced Research, Vol 28, Iss, Pp 97-109 (2021)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • Neuroinflammation plays a key role in the secondary injury of acute SCI. • Pyroptosis is defined as a newly programmed cell death. • Recent studies show that pyroptosis play a key role in SCI. • Some molec
Highlights • Neuroinflammation plays a key role in the secondary injury of acute SCI. • Pyroptosis is defined as a newly programmed cell death. • Recent studies show that pyroptosis play a key role in SCI. • Some molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aaa585b7dc4e7f4e03b92a67b2a015
http://www.sciencedirect.com/science/article/pii/S2090123220301880
http://www.sciencedirect.com/science/article/pii/S2090123220301880