GHB – Induced Cognitive Deficits During Adolescence and the Role of NMDA Receptor

Autor: Sircar D, Ratna Sircar, Reddy K, Wu Lc, Basak Ak

Publikováno v: Current Neuropharmacology

We have earlier reported that γ-hydroxybutyric acid (GHB) disrupts the acquisition of spatial learning and memory in adolescent rats. GHB is known to interact with several neurotransmitter systems that have been implicated in cognitive functioning.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c0cabbc550fe7a6215a93608fb773e
https://doi.org/10.2174/157015911795017038

Glutamate downregulates the NR2A subunit of the NMDA-glutamate receptor and decreases the production of cAMP in Jurkat lymphoid T cells

Autor: S. Koriauli, N. Natsvlishvili, David Mikeladze

Publikováno v: Journal of Biological Physics and Chemistry. 8:111-114

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d627901c972bfaaf0289e862bddd6fc
https://doi.org/10.4024/23ko08l.jbpc.0804

Learning in the absence of experience-dependent regulation of NMDAR composition

Autor: Elizabeth M. Quinlan, David Lebel, Edi Barkai, Nishchal Sidhu

Publikováno v: Learning & Memory. 13:566-570

Olfactory discrimination (OD) learning consists of two phases: an initial N-methyl-d-aspartate (NMDA) receptor–sensitive rule-learning phase, followed by an NMDA receptor (NMDAR)–insensitive pair-learning phase. The rule-learning phase is accompa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b110426dae6f46429d8b83ab608f3f0c
https://doi.org/10.1101/lm.276606

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Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

Autor: Saskia Biskup, Jürgen Sperner, Stefan Herms, Anna-Elina Lehesjoki, Per Hoffmann, Markus Wolff, Rikke S. Møller, Hannelore Steinböck, José M. Serratosa, Peter De Jonghe, Ingo Helbig, Michael Alber, Markus Schilhabel, Laura Addis, Sarah E. Buerki, Gabriele Wohlrab, Birgit Neophythou, Johanna A. Jähn, Michael Nothnagel, Ulvi Vaher, D Edda Haberlandt, Ursula Gruber-Sedlmayr, Johannes R. Lemke, Yvonne G. Weber, Judith Kroell, Ulrich Stephani, Kadi Veri, Shan Tang, Natalio Fejerman, Gerhard Kluger, Jan Larsen, Susanne Ruf, Deb K. Pal, Sarah von Spiczak, Kirsten Geider, Bodo Laube, Gerhard Kurlemann, Martha Feucht, Dennis Lal, Bernd A. Neubauer, Robert J. Harvey, Tiina Talvik, Elaine Hughes, Tarja Linnankivi, Katrin Finsterwalder, Fritz Zimprich, Rainer Boor, Christina Kutzer, Petia Dimova, Andreas Hahn, Janine Altmüller, Christian Wilhelm, Barbara Fiedler, Felicitas Becker, Andre Franke, Helle Hjalgrim, Sarah Weckhuysen, Michael Schwake, Isabelle Steiner, Alexandre N. Datta, Gabriel M. Ronen, Rosa Guerrero López, Hiltrud Muhle, Mohammad R. Toliat, Holger Lerche, Eva M. Reinthaler, Peter Nürnberg, Roberto Caraballo, Holger Thiele, Wim Van Paesschen, Julia Geldner

Publikováno v: Lemke, J R, Lal, D, Reinthaler, E M, Steiner, I, Nothnagel, M, Alber, M, Geider, K, Laube, B, Schwake, M, Finsterwalder, K, Franke, A, Schilhabel, M, Jähn, J A, Muhle, H, Boor, R, Van Paesschen, W, Caraballo, R, Fejerman, N, Weckhuysen, S, De Jonghe, P, Larsen, J, Møller, R S, Hjalgrim, H, Addis, L, Tang, S, Hughes, E, Pal, D K, Veri, K, Vaher, U, Talvik, T, Dimova, P, Guerrero López, R, Serratosa, J M, Linnankivi, T, Lehesjoki, A-E, Ruf, S, Wolff, M, Buerki, S, Wohlrab, G, Kroell, J, Datta, A N, Fiedler, B, Kurlemann, G, Kluger, G, Hahn, A, Haberlandt, D E, Kutzer, C, Sperner, J, Becker, F, Weber, Y G, Feucht, M, Steinböck, H, Neophythou, B, Ronen, G M, Gruber-Sedlmayr, U, Geldner, J, Harvey, R J, Hoffmann, P, Herms, S, Altmüller, J, Toliat, M R, Thiele, H, Nürnberg, P, Wilhelm, C, Stephani, U, Helbig, I, Lerche, H, Zimprich, F, Neubauer, B A, Biskup, S & von Spiczak, S 2013, ' Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes ', Nature Genetics, vol. 45, no. 9, pp. 1067-1072 . https://doi.org/10.1038/ng.2728
NATURE GENETICS
Nature genetics
Nature genetics 45(9), 1067-1072 (2013). doi:10.1038/ng.2728

Idiopathic focal epilepsy (IFE) with rolandic spikes is the most common childhood epilepsy, comprising a phenotypic spectrum from rolandic epilepsy (also benign epilepsy with centrotemporal spikes, BECTS) to atypical benign partial epilepsy (ABPE), L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0281aff55ae5d7df342ab95dbc568ddb
https://doi.org/10.5167/uzh-91805