Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nozomu Koyanagi"'
Autor:
Haruhiko Yoshida, Masao Omata, Ryoko Kuromatsu, Tetsuo Katamoto, Tatsuya Yamashita, Yukihiro Koike, Yoshiyuki Ueno, Kyosuke Yamamoto, Naohiko Masaki, Kunihiko Tsuji, Hiroko Oka, Takao Kawabe, Akihisa Ishikawa, Toshiya Osawa, Isao Sakaida, Yasuyuki Araki, Toshihiko Mizuta, Minoru Nomoto, Masamichi Kojiro, Hidekatsu Kuroda, Shuichiro Shiina, Kentaro Kikuchi, Namiki Izumi, Masataka Seike, Kazumi Tagawa, Kenichi Saito, Hiroshi Ikeda, Nozomu Koyanagi, Haruhiko Kobashi, Shotaro Sakisaka, Hiroshi Kasugai, Joji Toyota, Seiji Kawazoe, Masao Ichinose, Toshihito Seki, Yukio Osaki, Yasushi Shiratori, Hiroyuki Kokuryu, Masatoshi Kudo
Publikováno v:
Hepatology. 54:532-540
Hepatocellular carcinoma (HCC) is characterized by frequent recurrence, even after curative treatment. Vitamin K2, which has been reported to reduce HCC development, may be effective in preventing HCC recurrence. Patients who underwent curative ablat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29cc7e50600cf735103614986d82a75
https://doi.org/10.1002/hep.24430
https://doi.org/10.1002/hep.24430
Autor:
Kentaro Yoshimatsu, Katsuji Nakamura, Takeshi Nagasu, Hiroyuki Sugumi, Jun Niijima, Toshimi Okada, Toshimitsu Uenaka, Nozomu Koyanagi, Kappei Tsukahara, Atsumi Yamaguchi, Hiroshi Yoshino, Kyosuke Kitoh, Junichi Kamata, Yoshihiko Kotake
Publikováno v:
Chemical and Pharmaceutical Bulletin. 52:1071-1081
As part of a series of studies to discover new topoisomerase II inhibitors, novel pyrimidoacridones, pyrimidophenoxadines, and pyrimidocarbazoles were synthesized, and in vitro and in vivo antitumor activities and DNA-protein and/or DNA-topoisomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dc5f0c0baabab56e3b6f243222fc67
https://doi.org/10.1248/cpb.52.1071
https://doi.org/10.1248/cpb.52.1071
Autor:
Takeshi Nagasu, Tatsuo Okauchi, Hiroshi Yoshino, Yoichi Ozawa, Kentaro Yoshimatsu, Takashi Owa, Nozomu Koyanagi, Kyosuke Kitoh, Tadashi Okabe, Naoko Hata Sugi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2097-2100
We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its toler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee916508bb3e72d63ebe5d8a9c3ebf09
https://doi.org/10.1016/s0960-894x(02)00376-1
https://doi.org/10.1016/s0960-894x(02)00376-1
Publikováno v:
Cancer Chemotherapy and Pharmacology. 47:179-184
Purpose: E7010 is an orally active sulfonamide antitumor agent showing good activity against various subcutaneously inoculated rodent tumors and human tumor xenografts. The purpose of this study was to evaluate the effect of E7010 on liver metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8bf10026ced0ca183c554f5feff5f9
https://doi.org/10.1007/s002800000199
https://doi.org/10.1007/s002800000199
Autor:
Naoko Hata Sugi, Takashi Owa, Kentaro Yoshimatsu, Kyosuke Kitoh, Nozomu Koyanagi, T. Watanabe, Takeshi Nagasu, Hiroshi Yoshino, Yoichi Ozawa
Publikováno v:
European Journal of Cancer. 37:2275-2282
E7070 (N-(3-Chloro-7-indolyl)-1,4-benzenedisulphonamide) was selected from our sulphonamide compound collections via antitumour screening and flow cytometric analysis. Following treatment with E7070, the cell cycle progression of P388 murine leukaemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93720b748394b56c42dee132ee5a1603
https://doi.org/10.1016/s0959-8049(01)00275-1
https://doi.org/10.1016/s0959-8049(01)00275-1
Autor:
Takeshi Nagasu, Naoko Hata Sugi, Nozomu Koyanagi, Hiroshi Yoshino, Takashi Owa, Kyosuke Kitoh, Tatsuo Okauchi, Kentaro Yoshimatsu, Tadashi Okabe, Yoichi Ozawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1223-1226
A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531dad03953c1e9f534bbb2bce8595c0
https://doi.org/10.1016/s0960-894x(00)00219-5
https://doi.org/10.1016/s0960-894x(00)00219-5
Autor:
Yoichi Ozawa, Kentaro Yoshimatsu, Nozomu Koyanagi, Tatsuo Okauchi, Takeshi Nagasu, Naoko Hata Sugi, Hiroshi Yoshino, Kyosuke Kitoh, Takashi Owa
Publikováno v:
Journal of Medicinal Chemistry. 42:3789-3799
Described herein is the discovery of a novel series of antitumor sulfonamides targeting G1 phase of the cell cycle. Cell cycle control in G1 phase has attracted considerable attention in recent cancer research, because many of the important proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f24d3b989b5a13c1b106518ae983f4c
https://doi.org/10.1021/jm9902638
https://doi.org/10.1021/jm9902638
Publikováno v:
Journal of Surgical Oncology. 71:83-90
Background and Objectives Orthotopic transplantation of human colon tumors was a useful method for producing hepatic metastasis in mice. In many cases, however, it took about 3 months for evaluation. We examined an in vivo model of hepatic metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40ab585cf580349bf4a182140c6f3a1
https://doi.org/10.1002/(sici)1096-9098(199906)71:2<83::aid-jso5>3.0.co
https://doi.org/10.1002/(sici)1096-9098(199906)71:2<83::aid-jso5>3.0.co
Autor:
Kyosuke Kitoh, N. Tamai, Yoshihiko Kotake, Yoichi Ozawa, Atsumi Iijima, Kentaro Yoshimatsu, Hiroaki Nomura, Nozomu Koyanagi
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e84ff65ce2ef3128652b8b863d310b0
https://doi.org/10.1002/chin.199443240
https://doi.org/10.1002/chin.199443240
Autor:
Kentaro Yoshimatsu, Takashi Owa, Nozomu Koyanagi, Takeshi Nagasu, Tadashi Okabe, Naoko Hata Sugi, Tatsuo Okauchi, Yoichi Ozawa, Kyosuke Kitoh, Hiroshi Yoshino
Publikováno v:
ChemInform. 33
We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its toler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a91dac1b672c162fa3b9c266f5bb18da
https://doi.org/10.1002/chin.200249130
https://doi.org/10.1002/chin.200249130