Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Nozomu, Kono"'
Autor:
Chiaki Inoue, Kojiro Mukai, Tatsuyuki Matsudaira, Jun Nakayama, Nozomu Kono, Junken Aoki, Hiroyuki Arai, Yasunori Uchida, Tomohiko Taguchi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Yes-associated protein (YAP) is a transcriptional coactivator that is essential for the malignancy of various cancers. We have previously shown that YAP activity is positively regulated by phosphatidylserine (PS) in recycling endosomes (REs)
Externí odkaz:
https://doaj.org/article/8d6cacaebed848179498734751cbfd5d
Autor:
Sari Sugahara, Yuki Ishino, Koki Sawada, Tsumugi Iwata, Yuta Shimanaka, Junken Aoki, Hiroyuki Arai, Nozomu Kono
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100443- (2023)
Phosphatidylserine (PS) is an acidic phospholipid that is involved in various cellular events. Heterologous dominant mutations have been identified in the gene encoding PS synthase 1 (PSS1) in patients with a congenital disease called Lenz-Majewski s
Externí odkaz:
https://doaj.org/article/65aeb195de3f4f9ab3916345f171d867
Autor:
Kasparas Petkevicius, Henrik Palmgren, Matthew S. Glover, Andrea Ahnmark, Anne-Christine Andréasson, Katja Madeyski-Bengtson, Hiroki Kawana, Erik L. Allman, Delaney Kaper, Martin Uhrbom, Liselotte Andersson, Leif Aasehaug, Johan Forsström, Simonetta Wallin, Ingela Ahlstedt, Renata Leke, Daniel Karlsson, Hernán González-King, Lars Löfgren, Ralf Nilsson, Giovanni Pellegrini, Nozomu Kono, Junken Aoki, Sonja Hess, Grzegorz Sienski, Marc Pilon, Mohammad Bohlooly-Y, Marcello Maresca, Xiao-Rong Peng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The regulation of cellular phosphatidylethanolamine (PE) acyl chain composition is poorly understood. Here, the authors show that TLCD1 and TLCD2 proteins mediate the formation of monounsaturated fatty acid-containing PE species and promote the progr
Externí odkaz:
https://doaj.org/article/15464563b39b4d54986a8c040d9d92b8
Autor:
Zhikuan Zhang, Norimichi Nomura, Yukiko Muramoto, Toru Ekimoto, Tomoko Uemura, Kehong Liu, Moeko Yui, Nozomu Kono, Junken Aoki, Mitsunori Ikeguchi, Takeshi Noda, So Iwata, Umeharu Ohto, Toshiyuki Shimizu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
M protein plays essential roles in virus assembly and morphogenesis. Here, authors reveal two cryo-EM structures of M protein from SARS-CoV-2 that suggest conformational dynamics of M protein and its role in virus assembly.
Externí odkaz:
https://doaj.org/article/a5db8836d0a44eb0879660163e86a76f
Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling
Autor:
Hidenori Moriyama, Jin Endo, Masaharu Kataoka, Yuta Shimanaka, Nozomu Kono, Yuki Sugiura, Shinichi Goto, Hiroki Kitakata, Takahiro Hiraide, Naohiro Yoshida, Sarasa Isobe, Tsunehisa Yamamoto, Kohsuke Shirakawa, Atsushi Anzai, Yoshinori Katsumata, Makoto Suematsu, Kenjiro Kosaki, Keiichi Fukuda, Hiroyuki Arai, Motoaki Sano
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Pulmonary hypertension is a fatal disease that causes right heart failure due to pulmonary artery stenosis. Here, the authors find that ω-3 epoxides produced by the phospholipase PAF-AH2 in mast cells regulate pulmonary vascular remodeling.
Externí odkaz:
https://doaj.org/article/bf596d8cbe734fc7b41acec18cce7abc
Autor:
Takeaki Shibata, Hiroki Kawana, Yuri Nishino, Yoshiko Ito, Hiroyasu Sato, Hirofumi Onishi, Kuniyuki Kano, Asuka Inoue, Yoshitaka Taketomi, Makoto Murakami, Satoshi Kofuji, Hiroshi Nishina, Atsuo Miyazawa, Nozomu Kono, Junken Aoki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Phospholipids in the membrane consist of diverse pairs of fatty acids bound to a glycerol backbone. The biological significance of the diversity, however, remains mostly unclear. Part of this diversity is due to lysophospholipid acyltransfer
Externí odkaz:
https://doaj.org/article/121df52d1e1a4756bdb7aee0adf128be
Autor:
Yuta Shimanaka, Keiko Matsumoto, Yuki Tanaka, Yuki Ishino, Shenwei Ni, Jun-Lin Guan, Hiroyuki Arai, Nozomu Kono
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-10 (2022)
Phosphoinositide (PIP) species play important roles in a number of cellular events, but the simultaneous quantification of individual PIP species remains challenging using conventional methods. Here, the authors report a supercritical fluid chromatog
Externí odkaz:
https://doaj.org/article/caf2da6812934241b23ddaa97142df8d
Autor:
Hiroki Kawana, Masaya Ozawa, Takeaki Shibata, Hirofumi Onishi, Yukitaka Sato, Kuniyuki Kano, Hideo Shindou, Takao Shimizu, Nozomu Kono, Junken Aoki
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 10, Pp 100271- (2022)
The main fatty acids at the sn-1 position of phospholipids (PLs) are saturated or monounsaturated fatty acids such as palmitic acid (C16:0), stearic acid (C18:0), and oleic acid (C18:1) and are constantly replaced, like unsaturated fatty acids at the
Externí odkaz:
https://doaj.org/article/da1169dbe34f4f01a7fb010653c09042
Autor:
Taiga Iwama, Kuniyuki Kano, Hiroki Kawana, Hideo Shindou, Takao Shimizu, Nozomu Kono, Junken Aoki
Publikováno v:
Analytical Chemistry; 7/23/2024, Vol. 96 Issue 29, p11771-11779, 9p
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100029- (2021)
Abstract: Lysophosphatidic acid (LPA) is a potent signaling lipid, and state-dependent alterations in plasma LPA make it a promising diagnostic marker for various diseases. However, plasma LPA concentrations vary widely among reports, even under norm
Externí odkaz:
https://doaj.org/article/cb71ac2ab8934d2da7c4365a9589d3f0