Výsledky vyhledávání - "Nozomi Tomimatsu"

Akademický článek

DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis

Autor: Yuxin Huang, Wenjing Li, Tzeh Foo, Jae-Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu, Rouf Maqbool, Bipasha Mukherjee, Tengyang Ni, Salvador Alejo, Yuan He, Sandeep Burma, Li Lan, Bing Xia, Weixing Zhao

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA-binding domain (DBD) which is frequently targeted by cancer-associated pathogenic vari

Externí odkaz: https://doaj.org/article/f3092df21106479a9c84ccc7612b0ff2

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Akademický článek

Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing

Autor: Chaoyou Xue, Sameer J. Salunkhe, Nozomi Tomimatsu, Ajinkya S. Kawale, Youngho Kwon, Sandeep Burma, Patrick Sung, Eric C. Greene

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Bloom syndrome is a genetic disorder associated with increased cancer risk and is caused by mutations in Bloom helicase. This study investigates the mechanisms used by BLM helicase as initiates the repair of broken chromosomes.

Externí odkaz: https://doaj.org/article/249006cafba94dcf911c7aad8b796856

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Akademický článek

Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

Autor: James M. Daley, Nozomi Tomimatsu, Grace Hooks, Weibin Wang, Adam S. Miller, Xiaoyu Xue, Kevin A. Nguyen, Hardeep Kaur, Elizabeth Williamson, Bipasha Mukherjee, Robert Hromas, Sandeep Burma, Patrick Sung

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resectio

Externí odkaz: https://doaj.org/article/984479d037a94bbc940c8e7db07e22e0

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Akademický článek

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

Autor: Bipasha Mukherjee, Nozomi Tomimatsu, Kaushik Amancherla, Cristel V. Camacho, Nandini Pichamoorthy, Sandeep Burma

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 1, Pp 34-43 (2012)

Inhibitors of PI3K/Akt signaling are being actively developed for tumor therapy owing to the frequent mutational activation of the PI3K-Akt-mTORC1 pathway in many cancers, including glioblastomas (GBMs). NVP-BEZ235 is a novel and potent dual PI3K/mTO

Externí odkaz: https://doaj.org/article/3a0224af826648ffb77aacf013f8895b

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