Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nozomi Takai"'
Autor:
Yukari Tanaka, Nozomi Takai
Publikováno v:
Bioanalysis. 7:2639-2648
Analysis of drug and metabolite distribution is essential for understanding of the mechanisms underlying the pharmacological or toxicological effects. MS imaging (MSI) can visualize the distribution of drugs or biological molecules in tissue sections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e566d0e298a842fe196befa1421ef779
https://doi.org/10.4155/bio.15.184
https://doi.org/10.4155/bio.15.184
Autor:
Nozomi Takai, Misato Tonomura, Natsumi Imamoto, Naoki Kanegawa, Kenji Morimoto, Kohji Abe, Miwa Ito, Katsunori Sakai, Osamu Inoue, Kenichiro Todoroki, Kazumi Fukumoto
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 34:1907-1913
To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential of the hydroethidine derivative as a radiotracer to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f438aa5eabe33a41bee1d3d84d9fa88
https://doi.org/10.1038/jcbfm.2014.160
https://doi.org/10.1038/jcbfm.2014.160
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:1549-1556
RATIONALE Recently, the requirement for a quantitative research method using imaging mass spectrometry (IMS) to be developed has been discussed. Specifically, the simultaneous quantification of a drug in multiple organs by using whole-body sections c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2327ef28a1e81434ceb8664edcaf564d
https://doi.org/10.1002/rcm.6256
https://doi.org/10.1002/rcm.6256
Autor:
Hideo Saji, Nozomi Takai, Kantaro Nishigori, Yan Zhao, Masashi Shiomi, Yasushi Kiyono, Junko Kamihashi, Yuki Ogawa, Takashi Temma, Yuji Kuge, Seigo Ishino
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 37:2093-2104
Membrane type 1 matrix metalloproteinase (MT1-MMP) activates pro-MMP-2 and pro-MMP-13 to their active forms and plays important roles in the destabilization of atherosclerotic plaques. This study sought to determine the usefulness of (99m)Tc-labelled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b175a297ced680b670894bbb4c0cd6
https://doi.org/10.1007/s00259-010-1521-2
https://doi.org/10.1007/s00259-010-1521-2
Publikováno v:
Biological and Pharmaceutical Bulletin. 32:1272-1277
Membrane type-1 matrix metalloproteinase (MT1-MMP) expressed on the tumor cell surface activates pro-MMP-2 and pro-MMP-13 to exacerbate the malignancy, suggesting its suitability as a target molecule for diagnosis by in vivo molecular imaging. Thus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d47a5896ce4498151a2582164f73335
https://doi.org/10.1248/bpb.32.1272
https://doi.org/10.1248/bpb.32.1272
Autor:
Noriaki Kume, Seigo Ishino, Junko Kamihashi, Nozomi Takai, Mikako Ogawa, Toru Kita, Takahiro Mukai, Hideo Saji, Masashi Shiomi, Yuji Kuge, Manabu Minami
Publikováno v:
Journal of Nuclear Medicine. 49:1677-1685
Lectinlike oxidized low-density lipoprotein (LDL) receptor 1 (LOX-1), a cell surface receptor for oxidized LDL, has been implicated in vascular cell dysfunction related to plaque instability, which could be a potential target for an atherosclerosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fff2dab9fbed421a7777319095537c
https://doi.org/10.2967/jnumed.107.049536
https://doi.org/10.2967/jnumed.107.049536
Autor:
Nozomi Takai, Seigo Ishino, Takahiro Mukai, Yuji Kuge, Masashi Shiomi, Yuki Ogawa, Noriaki Kume, Hideo Saji, Manabu Minami
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:1475-1482
Background: Despite increasing in vitro evidence that lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL, is implicated in the atherogenesis and thrombus formation, its in vivo participatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7626e16e8b8c16f22eaffbb80c60b74
https://doi.org/10.1248/bpb.31.1475
https://doi.org/10.1248/bpb.31.1475
Autor:
Natsumi Imamoto, Kenji Morimoto, Miwa Ito, Kazumi Fukumoto, Sotaro Momosaki, Nozomi Takai, Misato Tonomura, Kae Fujisawa, Osamu Inoue, Kohji Abe, Nobuo Takasu
Publikováno v:
EJNMMI Research
Background Reactive oxygen species (ROS) have been implicated in cisplatin-induced nephrotoxicity. The aim of this study was to investigate the potential of using [3H]-labeled N-methyl-2,3-diamino-6-phenyl-dihydrophenanthridine ([3H]hydromethidine) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba16f99fdf6e486706f4fdd32cc7d6e2
https://doi.org/10.1186/s13550-015-0116-0
https://doi.org/10.1186/s13550-015-0116-0
Autor:
Kohji Abe, Kenji Morimoto, Miwa Ito, Nozomi Takai, Misato Tonomura, Natsumi Imamoto, Sotaro Momosaki, Kazumi Fukumoto, Takemi Rokugawa, Osamu Inoue
Publikováno v:
EJNMMI Research
Background Reactive oxygen species (ROS) have been implicated in the pathophysiology of the brain after ischemic stroke. In this study, we investigate the generation of brain ROS after transient focal ischemia in mice using a radical trapping radiotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dabf31581f7ba20fa55067dae43b17b
https://doi.org/10.1186/s13550-015-0115-1
https://doi.org/10.1186/s13550-015-0115-1
Autor:
Ayahisa Watanabe, Keiko Ogawa, Ryosuke Watari, Ken-ichi Nezasa, Ryosuke Shimizu, Nozomi Takai, Yukari Tanaka, Yoshitaka Yamaguchi
Publikováno v:
Journal of pharmaceutical sciences. 104(3)
In pharmacokinetic evaluation of mice, using serial sampling methods rather than a terminal blood sampling method could reduce the number of animals needed and lead to more reliable data by excluding individual differences. In addition, using serial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147ac2489f46a3175dea4676d76435f4
https://pubmed.ncbi.nlm.nih.gov/28756848
https://pubmed.ncbi.nlm.nih.gov/28756848