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Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain

Autor: Isamu Shiina, Natsumi Shibata, Takumi Iwasawa, Takahisa Shinomiya, Nozomi Ota, Kenya Nakata, Yukitoshi Nagahara

Publikováno v: Biological and Pharmaceutical Bulletin. 42:401-410

Ridaifen (RID)-B is an analog derived from tamoxifen (TAM). TAM has an antitumor effect by acting as an antagonist to estrogen receptor (ER). However, TAM is known to also induces apoptosis in cancer cells that do not have ER. We clarified that RID-B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8848c670a7d2c8fa1cb84824d9867aa
https://doi.org/10.1248/bpb.b18-00643

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Automated segmentation of 2D low-dose CT images of the psoas-major muscle using deep convolutional neural networks

Autor: Nozomi Ota, Shigeru Ito, Akihiro Kakimoto, Fumio Hashimoto, Sadahiko Nishizawa

Publikováno v: Radiological physics and technology. 12(2)

The psoas-major muscle has been reported as a predictive factor of sarcopenia. The cross-sectional area (CSA) of the psoas-major muscle in axial images has been indicated to correlate well with the whole-body skeletal muscle mass. In this study, we e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229aabacf3dc4e3a06032a6bdcc15dcb
https://pubmed.ncbi.nlm.nih.gov/30937726

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Anti-proliferative effect of ridaifen-B on hepatoma cells

Autor: G. O. Hasegawa, Kotomi Akatsuka, Isamu Shiina, Kayako Suda, Akihito Mizusawa, Natsumi Shibata, Yumiko Yokoe, Nozomi Ota, Keita Hiruma, Kaho Tsuchiya, Moyuru Hayashi, Motoyuki Shimonaka

Ridaifens (RIDs), a novel series of tamoxifen derivatives, exhibit a potent growth-inhibitory effect against numerous tumor cells regardless of the expression of estrogen receptors, and are thus promising candidates as novel anti-tumor drugs. RID-B i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671abc30fffb19f3988e0bdb7701828e
https://europepmc.org/articles/PMC6036825/

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Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors

Autor: Isamu Shiina, Tatsuki Sasaki, Yoichi Takakusagi, Fumio Sugawara, Senko Tsukuda, Shinji Kamisuki, Shingo Dan, Kengo Morohashi, Tomoe Kusayanagi, Nozomi Ota, Kentaro Ikeda, Shoko Uetake, Takao Yamori, Akihito Mizusawa

Publikováno v: Bioorganic & Medicinal Chemistry. 23:6118-6124

Ridaifen-G (RID-G), a tamoxifen analog that we previously synthesized, has potent growth inhibitory activity against various cancer cell lines. Tamoxifen is an anticancer drug known to act on an estrogen receptor (ER) and other proteins. However, our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad975c66b39e8c391f4af39cfae2a56
https://doi.org/10.1016/j.bmc.2015.08.001

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Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death

Autor: Makoto Hasegawa, Yunhao Zhu, Nozomi Ota, Masafumi Shionyu, Isamu Shiina, Natsumi Shibata, Ryuzo Sasaki, Tamio Mizukami, Akihito Mizusawa, Makoto Tanaka, Chihiro Watanabe

Publikováno v: European journal of medicinal chemistry. 146

Ridaifen-F (RID-F) potently inhibits proteolytic activities of the 20S proteasome but poorly inhibits those of the 26S proteasome. Here, we report preparation of several conjugates in which various peptides are connected to RID-F. Conjugates with pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c00beb24d4217f4a0e15f3528c29285
https://pubmed.ncbi.nlm.nih.gov/29407987

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