Identification of a novel TIF-IA–NF-κB nucleolar stress response pathway

Autor: Chen, Jingyu, Lobb, Ian T, Morin, Pierre, Novo, Sonia M, Simpson, James, Kennerknecht, Kathrin, von Kriegsheim, Alex, Batchelor, Emily E, Oakley, Fiona, Stark, Lesley A

Publikováno v: Chen, J, Lobb, I T, Morin, P, Novo, S M, Simpson, J, Kennerknecht, K, von Kriegsheim, A, Batchelor, E E, Oakley, F & Stark, L A 2018, ' Identification of a novel TIF-IA–NF-κB nucleolar stress response pathway ', Nucleic Acids Research, vol. 46, no. 12, pp. 6188–6205 . https://doi.org/10.1093/nar/gky455

p53 as an effector of nucleolar stress is well defined, but p53 independent mechanisms are largely unknown. Like p53, the NF-κB transcription factor plays a critical role in maintaining cellular homeostasis under stress. Many stresses that stimulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::6b4033de17f0697b0fc49d11ccd70abd
https://hdl.handle.net/20.500.11820/e16aa7be-73f0-4a29-b950-dd521ab462fa

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p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-kappa B subunit

Autor: O'Hara, Andrew, Simpson, James, Morin, Pierre, Loveridge, Carolyn J., Williams, Ann C., Novo, Sonia M., Stark, Lesley A.

Publikováno v: O'Hara, A, Simpson, J, Morin, P, Loveridge, C J, Williams, A C, Novo, S M & Stark, L A 2014, ' p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-kappa B subunit ', Journal of Cell Science, vol. 127, no. 17, pp. 3659-3665 . https://doi.org/10.1242/jcs.149328

Nucleolar sequestration of the RelA subunit of nuclear factor (NF)-kappa B is an important mechanism for regulating NF-kappa B transcriptional activity. Ubiquitylation, facilitated by COMMD1 (also known as MURR1), acts as a crucial nucleolar-targetin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::438ffb44af8730e7c2c1b187dae17578
https://www.pure.ed.ac.uk/ws/files/17191124/p300_mediated_acetylation_of_COMMD1_regulates_its_stability_and_the_ubiquitylation_and_nucleolar_translocation_of_the_RelA_NF_B_subunit.pdf

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