Rates of Adverse Events in Patients With Ulcerative Colitis Undergoing Colectomy During Treatment With Tofacitinib vs Biologics: A Multicenter Observational Study.

Autor: Dragoni G; IBD Referral Centre, Careggi University Hospital, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio,' University of Florence, Florence, Italy., Innocenti T; IBD Referral Centre, Careggi University Hospital, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio,' University of Florence, Florence, Italy., Amiot A; Department of Gastroenterology, Henri Mondor University Hospital, Paris Est-Creteil University, Creteil, France., Castiglione F; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy., Melotti L; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy., Festa S; IBD Unit, 'San Filippo Neri' Hospital, Rome, Italy., Savarino EV; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Truyens M; Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium., Argyriou K; Department of Gastroenterology, University Hospital of Larisa, Larissa, Greece., Noviello D; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Molnar T; Department of Gastroenterology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary., Bouillon V; Department of Gastroenterology, Erasme University Hospital, Brussels, Belgium., Bezzio C; IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Eder P; Department of Gastroenterology, Dietetics and Internal Medicine-Poznań University of Medical Sciences, Heliodor Święcicki University Hospital, Poznań, Poland., Fernandes S; Department of Gastroenterology and Hepatology, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte, Lisboa, Portugal.; Clínica Universitária da Faculdade de Medicina de Lisboa, Lisboa, Portugal., Kagramanova A; Moscow Clinical Scientific Center named after A.S. Loginov, Moscow, Russian Federation., Armuzzi A; IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Oliveira R; Gastroenterology Department, Algarve University Hospital Centre-Portimão Unit, Algarve, Portugal., Viola A; IBD-Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Ribaldone DG; Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy., Drygiannakis I; Department of Gastroenterology, University Hospital of Heraklion, Heraklion, Greece., Viganò C; Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Fondazione IRCCS San Gerardo dei Tintori, Monza, Italia., Calella F; SOC Gastroenterologia ed endoscopia digestiva, Azienda USL Toscana Centro, Ospedale 'San Giuseppe,' Empoli, Italy., Gravina AG; Hepatogastroenterology Unit, Department of Precision Medicine, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Pugliese D; CEMAD, IBD Unit, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy., Chaparro M; Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain., Ellul P; Department of Medicine, Division of Gastroenterology, Mater Dei Hospital, Msida, Malta., Vieujean S; Hepato-Gastroenterology and Digestive Oncology, University Hospital CHU of Liège, Liège, Belgium., Milla M; IBD Referral Centre, Careggi University Hospital, Florence, Italy., Caprioli F; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.

Publikováno v: The American journal of gastroenterology [Am J Gastroenterol] 2024 Aug 01; Vol. 119 (8), pp. 1525-1535. Date of Electronic Publication: 2024 Feb 02.

Comparison between tofacitinib and ustekinumab as a third-line therapy in refractory ulcerative colitis: A multicenter international study.

Autor: Allocca M; Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele and University Vita-Salute San Raffaele, Milan, Italy., Catalano G; Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele and University Vita-Salute San Raffaele, Milan, Italy., Savarino EV; Department of Surgery, Oncology and Gastroenterology, Division of Gastroenterology, University of Padua, Padua, Italy., Chaparro M; Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain., Levartovsky A; Gastroenterology, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel., Michalopoulos G; Gastroenterology, General Hospital of Athens 'G. Gennimatas', Athens, Greece., Viazis N; Gastroenterology, 'Evangelismos-Polykliniki' GHA, Athens, Greece., Fousekis FS; Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, University of Ioannina School of Health Sciences, Ioannina, Greece., Psistakis A; Gastroenterology, Venizeleio General Hospital, Heraklion, Crete, Greece., Noviello D; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Nascimento CND; Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal., Caron B; Department of Gastroenterology and Inserm NGERE 1256, University Hospital of Nancy, Université de Lorraine, Nancy, France., Kitsou V; GI-Unit, 3rd Academic Department of Internal Medicine, National & Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Bamias G; GI-Unit, 3rd Academic Department of Internal Medicine, National & Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., García MJ; Gastroenterology and Hepatology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain., Zacharopoulou E; Gastroenterology, General Hospital of Nikaia and Piraeus 'Agios Panteleimon'- General Hospital Dytikis Attikis 'Agia Varvara', Athens, Greece., Foteinogiannopoulou K; Gastroenterology, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Crete, Greece., D'Amico F; Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele and University Vita-Salute San Raffaele, Milan, Italy., Koutroubakis I; Gastroenterology, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Crete, Greece., Ellul P; Gastroenterology, Mater Dei Hospital, Msida, Malta., Tzouvala M; Gastroenterology, General Hospital of Nikaia and Piraeus 'Agios Panteleimon'- General Hospital Dytikis Attikis 'Agia Varvara', Athens, Greece., Peyrin-Biroulet L; Department of Gastroenterology and Inserm NGERE 1256, University Hospital of Nancy, Université de Lorraine, Nancy, France.; Groupe Hospitalier privé Ambroise Paré - Hartmann, Paris IBD Center, Neuilly sur Seine, France., Torres J; Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal., Caprioli F; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Karmiris K; Gastroenterology, Venizeleio General Hospital, Heraklion, Crete, Greece., Theodoropoulou A; Gastroenterology, Venizeleio General Hospital, Heraklion, Crete, Greece., Katsanos KH; Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, University of Ioannina School of Health Sciences, Ioannina, Greece., Christodoulou DK; Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, University of Ioannina School of Health Sciences, Ioannina, Greece., Mantzaris GJ; Gastroenterology, 'Evangelismos-Polykliniki' GHA, Athens, Greece., Kopylov U; Gastroenterology, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel., Gisbert JP; Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain., Danese S; Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele and University Vita-Salute San Raffaele, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Magro F; Gastroenterology and Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal., Carla F; Department of Medicine and Surgery, Research Centre on Public Health, University of Milano -Bicocca, Monza, Italy., Fiorino G; Vita-Salute San Raffaele University, Milan, Italy.; Gastroenterology and Digestive Endoscopy, San Camillo-Forlanini Hospital, Rome, Italy.

Publikováno v: United European gastroenterology journal [United European Gastroenterol J] 2024 Jun; Vol. 12 (5), pp. 543-551. Date of Electronic Publication: 2024 Feb 28.

The carbon cost of inappropriate endoscopy.

Autor: Elli L; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., La Mura S; Department of Energy, Politecnico di Milano, Milan, Italy., Rimondi A; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Scaramella L; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Tontini GE; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Monica F; Gastroenterology and Digestive Endoscopy, Academic Hospital Cattinara, Trieste, Italy., Soncini M; Department of Internal Medicine, A. Manzoni Hospital, Lecco, Italy., Topa M; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Bortoluzzi F; Gastrointestinal Unit, Ospedale dell'Angelo, Venice, Italy., Sorge A; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Cavallaro F; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Nandi N; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Noviello D; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Piagnani A; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Maregatti M; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Caldato M; Cascina Brandezzata Hospice, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Vecchi M; Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Publikováno v: Gastrointestinal endoscopy [Gastrointest Endosc] 2024 Feb; Vol. 99 (2), pp. 137-145.e3. Date of Electronic Publication: 2023 Sep 09.

An Intestinal Th17 Subset is Associated with Inflammation in Crohn's Disease and Activated by Adherent-invasive Escherichia coli.

Autor: Paroni M; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy.; Department of Biosciences, Università degli Studi di Milano, Milan, Italy., Leccese G; Department of Biosciences, Università degli Studi di Milano, Milan, Italy., Ranzani V; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Moschetti G; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Chiara M; Department of Biosciences, Università degli Studi di Milano, Milan, Italy., Perillo F; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy., Ferri S; Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy., Clemente F; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Noviello D; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Conforti FS; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Ferrero S; Pathology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Biomedical, Surgical, and Dental Sciences, Università degli Studi di Milano, Milan, Italy., Karnani B; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Bosotti R; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Vasco C; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Curti S; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Crosti MC; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Gruarin P; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy., Rossetti G; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy.; Molecular Oncology and Immunology, FIRC Institute of Molecular Oncology [IFOM], Milan, Italy., Conte MP; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, Rome, Italy., Vecchi M; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Pagani M; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy.; Molecular Oncology and Immunology, FIRC Institute of Molecular Oncology [IFOM], Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Landini P; Department of Biosciences, Università degli Studi di Milano, Milan, Italy., Facciotti F; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy.; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.; Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy., Abrignani S; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy.; DISCCO, Department of Clinical Science and Community Health, University of Milan, Milan, Italy., Caprioli F; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Geginat J; INGM-National Institute of Molecular Genetics 'Romeo ed Enrica Invernizzi', Milan, Italy.; DISCCO, Department of Clinical Science and Community Health, University of Milan, Milan, Italy.

Publikováno v: Journal of Crohn's & colitis [J Crohns Colitis] 2023 Dec 30; Vol. 17 (12), pp. 1988-2001.

Gut virome-colonising Orthohepadnavirus genus is associated with ulcerative colitis pathogenesis and induces intestinal inflammation in vivo .

Autor: Massimino L; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy.; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy., Palmieri O; Division of Gastroenterology and Endoscopy, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Foggia, Italy., Facoetti A; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Fuggetta D; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Spanò S; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy.; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy., Lamparelli LA; IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., D'Alessio S; PhoenixLAB, Lodi, Italy., Cagliani S; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Furfaro F; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy., D'Amico F; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy., Zilli A; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy., Fiorino G; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Parigi TL; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Noviello D; Department of Pathophysiology and Transplantation, University of Milan, Milano, Italy., Latiano A; Division of Gastroenterology and Endoscopy, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Foggia, Italy., Bossa F; Division of Gastroenterology and Endoscopy, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Foggia, Italy., Latiano T; Division of Gastroenterology and Endoscopy, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Foggia, Italy., Pirola A; GalSeq s.r.l, Milan, Italy., Mologni L; Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Piazza RG; Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; Hematology and Clinical Research Unit, San Gerardo Hospital, Monza, Italy., Abbati D; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy., Perri F; Division of Gastroenterology and Endoscopy, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Foggia, Italy., Bonini C; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Peyrin-Biroulet L; Inserm NGERE, University of Lorraine, Nancy, France.; Department of Hepato-Gastroenterology, University Hospital Centre Nancy, Nancy, France., Malesci A; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Jairath V; Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada., Danese S; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy.; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy., Ungaro F; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milano, Italy ungaro.federica@hsr.it.; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy.; Faculty of Medicine, Università Vita Salute San Raffaele, Milano, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Publikováno v: Gut [Gut] 2023 Oct; Vol. 72 (10), pp. 1838-1847. Date of Electronic Publication: 2023 Feb 14.