Angiopoietin-Like Protein 3 Promotes Preservation of Stemness during Ex Vivo Expansion of Murine Hematopoietic Stem Cells

Autor: Shazia Arshad, Trudi P. Visser, Elnaz Farahbakhshian, Dirk Geerts, Niek P. van Til, Frank Grosveld, Noveen Riaz, Sima Kheradmandkia, Jules P.P. Meijerink, Monique M A Verstegen

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105642 (2014)
Farahbakhshian, E, Verstegen, M M, Visser, T P, Kheradmandkia, S, Geerts, D, Arshad, S, Riaz, N, Grosveld, F, van Til, N P & Meijerink, J P P 2014, ' Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells ', PLoS ONE, vol. 9, no. 8, pp. e105642 . https://doi.org/10.1371/journal.pone.0105642
PLoS ONE
PLoS One (print), 9(8). Public Library of Science
PLoS ONE, 9(8). Public Library of Science

Allogeneic hematopoietic stem cell (HSC) transplantations from umbilical cord blood or autologous HSCs for gene therapy purposes are hampered by limited number of stem cells. To test the ability to expand HSCs in vitro prior to transplantation, two g

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https://doi.org/10.1371/journal.pone.0105642