Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Novalia, Pishesha"'
Autor:
Elisha R. Verhaar, Anouk Knoflook, Novalia Pishesha, Xin Liu, Willemijn J. C. van Keizerswaard, Kai W. Wucherpfennig, Hidde L. Ploegh
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
MICA and MICB are Class I MHC-related glycoproteins that are upregulated on the surface of cells in response to stress, for instance due to infection or malignant transformation. MICA/B are ligands for NKG2D, an activating receptor on NK cells, CD8+
Externí odkaz:
https://doaj.org/article/4230f67bb0f74c8fb8136fca687a145b
Autor:
Paul W. Rothlauf, Zeyang Li, Novalia Pishesha, Yushu Joy Xie, Andrew W. Woodham, Djenet Bousbaine, Stephen C. Kolifrath, Vincent L. Verschoor, Hidde L. Ploegh
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immuno-positron emission tomography (immuno-PET) is a noninvasive imaging method that enables tracking of immune cells in living animals. We used a nanobody that recognizes mouse CD8α and labeled it with 89Zr to image mouse CD8+ T cells in the cours
Externí odkaz:
https://doaj.org/article/ec6daeeda9f54e4fa8a2670439ceeeaf
Autor:
Rhogerry Deshycka, Valentino Sudaryo, Nai-Jia Huang, Yushu Xie, Liyan Y. Smeding, Moon Kyung Choi, Hidde L. Ploegh, Harvey F. Lodish, Novalia Pishesha
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Low plasma levels of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) are associated with decreased low-density lipoprotein (LDL) cholesterol and a reduced risk of cardiovascular disease. PCSK9 binds to the epidermal growth factor-like repeat A (EGFA
Externí odkaz:
https://doaj.org/article/6e2cb9ebe8ff46288add6d9019ba5414
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs). Here, we considered
Externí odkaz:
https://doaj.org/article/c9c7f73f218b48b3adc9eb2198b61764
Autor:
Nai-Jia Huang, Novalia Pishesha, Jean Mukherjee, Sicai Zhang, Rhogerry Deshycka, Valentino Sudaryo, Min Dong, Charles B. Shoemaker, Harvey F. Lodish
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The therapeutic use of single-chain antibodies (VHHs) is limited by their short half-life in the circulation. Here the authors engineer mouse and human red blood cells to express VHHs against botulinum neurotoxin A (BoNT/A) on their surface and show
Externí odkaz:
https://doaj.org/article/cc5b7658df0d48e1aa16746d22081aea
Autor:
Novalia Pishesha, Thibault Harmand, Claire Carpenet, Xin Liu, Atul Bhan, Ashraful Islam, Renate van den Doel, William Pinney, Hidde L. Ploegh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(43)
The distribution of Ly6C/G-positive cells in response to an infection of the mouse respiratory tract with influenza A virus was followed noninvasively over time by immuno-positron emission tomography. We converted nanobodies that recognize Ly6C and L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7082cd0a784e13b187177f791da60e8b
https://pubmed.ncbi.nlm.nih.gov/36252038
https://pubmed.ncbi.nlm.nih.gov/36252038
Autor:
Hidde L. Ploegh, Noor Momin, Tao Fang, Novalia Pishesha, Jessica R. Ingram, Michael Dougan, Yushu Joy Xie
Chimeric antigen receptor (CAR) T-cell therapy is effective in the treatment of cancers of hematopoietic origin. In the immunosuppressive solid tumor environment, CAR T cells encounter obstacles that compromise their efficacy. We developed a strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7442a6ef5389991a500ac45e44b91090
https://doi.org/10.1158/2326-6066.c.6550033.v1
https://doi.org/10.1158/2326-6066.c.6550033.v1
Autor:
Stephanie K. Dougan, Hidde L. Ploegh, Ulrich H. von Andrian, Quang-De Nguyen, Mohammad Rashidian, Mariah M. Servos, Paul M. Tyler, Olga Blomberg, Novalia Pishesha, Lestat Ali, Patrick T. Bruck, Munir M. Mosaheb, Hee-Jin Jeong, Jessica R. Ingram, Michael Dougan
S6. A12-IFNγ alters the tumor microenvironment in KPC organoid model of pancreatic cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eeab2ddf65065bd70c2ec3f5c4c9796
https://doi.org/10.1158/2326-6066.22540097
https://doi.org/10.1158/2326-6066.22540097
Autor:
Stephanie K. Dougan, Hidde L. Ploegh, Ulrich H. von Andrian, Quang-De Nguyen, Mohammad Rashidian, Mariah M. Servos, Paul M. Tyler, Olga Blomberg, Novalia Pishesha, Lestat Ali, Patrick T. Bruck, Munir M. Mosaheb, Hee-Jin Jeong, Jessica R. Ingram, Michael Dougan
Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a71fd01468783f14b9fc002e6399036
https://doi.org/10.1158/2326-6066.c.6549281
https://doi.org/10.1158/2326-6066.c.6549281