Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion.

Autor: Lamarche C; Department of Surgery, University of British Columbia, Vancouver V6T 1Z4, BC, Canada.; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; Department of Medicine, Hôpital Maisonneuve-Rosemont Research Center, Université de Montréal, Montreal H1T 2M4, QC, Canada., Ward-Hartstonge K; Department of Surgery, University of British Columbia, Vancouver V6T 1Z4, BC, Canada.; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand., Mi T; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105., Lin DTS; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, BC, Canada., Huang Q; Department of Surgery, University of British Columbia, Vancouver V6T 1Z4, BC, Canada.; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada., Brown A; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver V6T 1Z4, BC, Canada., Edwards K; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, BC, Canada., Novakovsky GE; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, BC, Canada., Qi CN; Department of Surgery, University of British Columbia, Vancouver V6T 1Z4, BC, Canada.; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada., Kobor MS; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, BC, Canada., Zebley CC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105., Weber EW; Division of Oncology, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104., Mackall CL; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305.; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305., Levings MK; Department of Surgery, University of British Columbia, Vancouver V6T 1Z4, BC, Canada.; BC Children's Hospital Research Institute, Vancouver V5Z 4H4, BC, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver V6T 1Z4, BC, Canada.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 04; Vol. 120 (14), pp. e2219086120. Date of Electronic Publication: 2023 Mar 27.

bioSyntax: syntax highlighting for computational biology.

Autor: Babaian A; Terry Fox Laboratory, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada. ababaian@bccrc.ca.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. ababaian@bccrc.ca., Ebou A; Departement de Formation et de Recherches Agriculture et Ressources Animales, Institut National Polytechnique Felix Houphouet-Boigny, Yamoussoukro, Côte d'Ivoire., Fegen A; Faculty of Science, University of British Columbia, Vancouver, BC, Canada., Kam HY; Faculty of Mathematics, University of Waterloo, Waterloo, ON, Canada., Novakovsky GE; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Wong J; Genome Science and Technology, University of British Columbia, Vancouver, BC, Canada., Aïssi D; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany., Yao L; THU-PKU Joint Center for Life Sciences, Tsinghua University, Beijing, China.

Publikováno v: BMC bioinformatics [BMC Bioinformatics] 2018 Aug 22; Vol. 19 (1), pp. 303. Date of Electronic Publication: 2018 Aug 22.

A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4.

Autor: Evstafieva AG; 1] Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia [2] Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119992, Russia., Garaeva AA; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119992, Russia., Khutornenko AA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia., Klepikova AV; 1] Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119992, Russia [2] Faculty of Biology, Department of Genetics, Lomonosov Moscow State University, Moscow, 119992, Russia., Logacheva MD; 1] Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia [2] Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119992, Russia., Penin AA; 1] Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119992, Russia [2] Faculty of Biology, Department of Genetics, Lomonosov Moscow State University, Moscow, 119992, Russia., Novakovsky GE; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119992, Russia., Kovaleva IE; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia., Chumakov PM; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Street 32, Moscow, 119991, Russia.

Publikováno v: Cell death & disease [Cell Death Dis] 2014 Nov 06; Vol. 5, pp. e1511. Date of Electronic Publication: 2014 Nov 06.