Výsledky vyhledávání - "Novakovic, Mihajlo"

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On the Potential of Fourier-Encoded Saturation Transfers for Sensitizing Solid-State Magic-Angle Spinning NMR Experiments

Autor: Jaroszewicz, Michael J., Novakovic, Mihajlo, Frydman, Lucio

Chemical exchange saturation transfer (CEST) is widely used for enhancing the solution NMR signatures of magnetically-dilute spin pools; in particular species at low concentrations undergoing chemical exchanges with an abundant spin pool. CEST's main

Externí odkaz: http://arxiv.org/abs/2110.15451

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Heteronuclear transfers from labile protons in biomolecular NMR: Cross Polarization, revisited

Autor: Novakovic, Mihajlo, Jayanthi, Sundaresan, Lupulescu, Adonis, Concilio, Maria Grazia, Kim, Jihyun, Columbus, David, Kuprov, Ilya, Frydman, Lucio

INEPT- and HMQC-based pulse sequences are widely used to transfer polarization between heteronuclei, particularly in biomolecular spectroscopy: they are easy to setup and involve low power deposition. Still, these short-pulse polarization transfers s

Externí odkaz: http://arxiv.org/abs/2109.01079

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Assessing site-specific enhancements imparted by hyperpolarized water in folded and unfolded proteins by 2D HMQC NMR

Autor: Szekely, Or, Olsen, Gregory Lars, Novakovic, Mihajlo, Rosenzweig, Rina, Frydman, Lucio

Hyperpolarized water can be a valuable aid in protein NMR, leading to amide group 1H polarizations that are orders of magnitude larger than their thermal counterparts. Suitable procedures can exploit this to deliver 2D 1H-15N correlations with good r

Externí odkaz: http://arxiv.org/abs/2004.12813

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Hadamard magnetization transfers achieve dramatic sensitivity enhancements in homonuclear multidimensional NMR correlations of labile sites in proteins, polysaccharides and nucleic acids

Autor: Novakovic, Mihajlo, Kupce, Eriks, Oxenfarth, Andreas, Battistel, Marcos D., Freedberg, Daron I., Schwalbe, Harald, Frydman, Lucio

EXSY, TOCSY and NOESY lie at the foundation of homonuclear NMR experiments in organic and pharmaceutical chemistry, as well as in structural biology. Limited magnetization transfer efficiency is an intrinsic downside of these methods, particularly wh

Externí odkaz: http://arxiv.org/abs/2004.13063

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Enhanced Hyperpolarized Chemical Shift Imaging Based on a priori Segmented Information

Autor: Farkash, Gil, Markovic, Stefan, Novakovic, Mihajlo, Frydman, Lucio

Purpose: To develop an approach for improving the resolution and sensitivity of hyperpolarized 13C MRSI based on a priori anatomical information derived from featured, water-based 1H images. Methods: A reconstruction algorithm exploiting 1H MRI for t

Externí odkaz: http://arxiv.org/abs/1811.09370

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