A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors

Autor: Tiffany Hood, Fern Slingsby, Viktor Sandner, Winfried Geis, Timo Schmidberger, Nicola Bevan, Quentin Vicard, Julia Hengst, Pierre Springuel, Noushin Dianat, Qasim A. Rafiq

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Ex vivo genetically-modified cellular immunotherapies, such as chimeric antigen receptor T cell (CAR-T) therapies, have generated significant clinical and commercial outcomes due to their unparalleled response rates against relapsed and refractory bl

Externí odkaz: https://doaj.org/article/88a6db15b9b047b2b3a776a3de30ffb6

Cellules souches pluripotentes humaines et modélisation de maladies hépatiques

Autor: Noushin Dianat, Anne Dubart-Kupperschmitt, Anne Weber

Publikováno v: Biologie Aujourd'hui. 210:19-26

Le foie est associe a de nombreuses pathologies parmi lesquelles les maladies metaboliques et cholestatiques, les cirrhoses, les hepatites chroniques et aigues. Toutefois, la connaissance des mecanismes impliques dans la physiopathologie de ces malad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::036b83f7cffe70404b910b3bf6899b8b
https://doi.org/10.1051/jbio/2016006

Messenger RNA- Versus Retrovirus-Based Induced Pluripotent Stem Cell Reprogramming Strategies: Analysis of Genomic Integrity

Autor: Noushin Dianat, Inmaculada Moreno-Gimeno, Eléanor Luce, Anne Dubart-Kupperschmitt, Gérard Tachdjian, Joëlle Marie, Clara Steichen, Lucie Tosca, Jérome Maluenda, Deborah J. Burks, Christophe Desterke, Judith Melki, Sylvie Goulinet-Mainot, Sarah Awan-Toor, Anne Weber

Publikováno v: Stem Cells Translational Medicine
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname

The use of synthetic messenger RNAs to generate human induced pluripotent stem cells (iPSCs) is particularly appealing for potential regenerative medicine applications, because it overcomes the common drawbacks of DNA-based or virus-based reprogrammi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91942aa5c29f66c97ae603704f6872f3

The potential of induced pluripotent stem cell derived hepatocytes

Autor: Anne Weber, Zara Hannoun, Anne Dubart-Kupperschmitt, Noushin Dianat, Clara Steichen

Publikováno v: Journal of hepatology. 65(1)

Orthotopic liver transplantation remains the only curative treatment for liver disease. However, the number of patients who die while on the waiting list (15%) has increased in recent years as a result of severe organ shortages; furthermore the incid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1d790b7d3871ac67d57c3c9052372e
https://pubmed.ncbi.nlm.nih.gov/26916529

Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells

Autor: Anne Weber, Philippe Leclerc, Anne Corlu, Christophe Desterke, Noushin Dianat, Aurélien Raveux, Hélène Dubois-Pot-Schneider, Laurent Combettes, Clara Steichen, Anne Dubart-Kupperschmitt

Publikováno v: Hepatology (Baltimore, Md.)
Hepatology
Hepatology, Wiley-Blackwell, 2014, 60 (2), pp.700--714. ⟨10.1002/hep.27165⟩
Hepatology, 2014, 60 (2), pp.700--714. ⟨10.1002/hep.27165⟩

International audience; Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development. In this study we investigated the potential of human embryonic stem cells (hESCs) to differentiate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faac062e8c0cb6eff8a809302ddc55d1
https://pubmed.ncbi.nlm.nih.gov/24715669