Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Noune Tahmassian Morse"'
Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity
Autor:
Melinda Przetak, Aditee Deshpande, Simone C. Zimmerli, Noune Tahmassian Morse, Evgeni Tzvetkov, Albertina Pereira, Sonja Reissig, Robert L. Walsky, Shinji L. Okitsu, Philipp Haselmayer, Djordje Musil, Sherer Brian A, Jaromir Vlach, Theresa L. Johnson, Andrew Bender
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:397-409
Toll-like receptor (TLR) 7 and TLR8 are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production, which is normally a protective host response. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963e63bf34625b4b6f50f0a262d440b1
https://doi.org/10.1124/jpet.120.000275
https://doi.org/10.1124/jpet.120.000275
Autor:
Shinji L. Okitsu, Sherer Brian A, Philipp Haselmayer, Evgeni Tzvetkov, Andrew Bender, Melinda Przetak, Albertina Pereira, Noune Tahmassian Morse, Jaromir Vlach, Sonja Reissig
Publikováno v:
Oral presentations.
Background TLR 7/8 are transmembrane receptors that recognize single-stranded RNA. In humans, TLR7 is mainly expressed in B cells and plasmacytoid dendritic cells and its activation stimulates antibody production and secretion of cytokines including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08c3e660bb1f65098a930a36dba4857f
https://doi.org/10.1136/lupus-2020-eurolupus.48
https://doi.org/10.1136/lupus-2020-eurolupus.48
Autor:
Hui Tian, Richard D. Caldwell, Jayadevan Jayashankaran, Andreas Goutopoulos, Srinivasa R. Karra, Sherer Brian A, Matthew Bleich, Susan Zhang, Jeyaprakashnarayanan Seenisamy, Noune Tahmassian Morse, Potnick Justin, Chekler Eugene, Mohanraj Dhanabal, Yufang Xiao, Venkataraman Sriraman
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(13)
The P2X7 receptor (P2X7R) plays an important role in diverse conditions associated with tissue damage and inflammation, suggesting that the human P2X7R (hP2X7R) is an attractive therapeutic target. In the present study, the synthesis and structure-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89f7c92fca5fbd2462d086687cb4644
https://pubmed.ncbi.nlm.nih.gov/31031055
https://pubmed.ncbi.nlm.nih.gov/31031055