Výsledky vyhledávání - "Nouf N. Alluqmani"

Impact of viral sensitizer-enhanced oncolytic virus immunotherapy on the anti-tumor immune response

Autor: Nouf N. Alluqmani, Anabel Bergeron, Andrew Chen, Sarwat Khan, Nicole Forbes, Rozanne Arulanandam, Christiano Souza, Debbi C. Crans, Jean-Simon Diallo

Publikováno v: The Journal of Immunology. 204:169.21-169.21

Oncolytic viruses (OVs) have emerged as promising anticancer treatment platforms, able to specifically replicate in and kill cancer cells. OVs also have immunostimulatory effects, promoting antitumor immune responses, and several strategies have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a6c42a7449913c73813283d5824376f
https://doi.org/10.4049/jimmunol.204.supp.169.21

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Complementary dual-virus strategy drives synthetic target and cognate T-cell engager expression for endogenous-antigen agnostic immunotherapy.

Autor: Taha Z; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. ztaha053@uottawa.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. ztaha053@uottawa.ca., Crupi MJF; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. mcrupi@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. mcrupi@ohri.ca., Alluqmani N; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., MacKenzie D; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Vallati S; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Whelan JT; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Fareez F; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Alwithenani A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Petryk J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Chen A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Spinelli MM; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ng K; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Sobh J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., de Souza CT; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Bharadwa PR; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Lee TKH; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Thomas DA; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Huang BZ; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Kassas O; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Poutou J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Gilchrist VH; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Boulton S; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Thomson M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Marius R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Hooshyar M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., McComb S; Cancer Immunology Team, National Research Council of Canada, Human Health Therapeutics, Ottawa, ON, K1A 0R6, Canada., Arulanandam R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ilkow CS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Bell JC; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jbell@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. jbell@ohri.ca., Diallo JS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jsdiallo@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. jsdiallo@ohri.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 23; Vol. 15 (1), pp. 7267. Date of Electronic Publication: 2024 Aug 23.

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Akademický článek

A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection.

Autor: Boulton S; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Poutou J; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Gill R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Alluqmani N; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., He X; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Singaravelu R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Crupi MJF; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Petryk J; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Austin B; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Angka L; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Taha Z; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Teo I; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Singh S; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Jamil R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Marius R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Martin N; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Jamieson T; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Azad T; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Faculty of Medicine and Health Sciences, Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.; Centre de Recherche du CHUS, Sherbrooke, QC J1H 5N4, Canada., Diallo JS; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Ilkow CS; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Bell JC; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2023 Sep 16; Vol. 31, pp. 101110. Date of Electronic Publication: 2023 Sep 16 (Print Publication: 2023).

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Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus.

Autor: Taha Z; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Crupi MJF; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Alluqmani N; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Fareez F; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Ng K; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Sobh J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Lee E; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Chen A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Thomson M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Spinelli MM; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Ilkow CS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Bell JC; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Arulanandam R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Diallo JS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Apr 19; Vol. 14, pp. 1181014. Date of Electronic Publication: 2023 Apr 19 (Print Publication: 2023).

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Akademický článek

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX.

Autor: Whelan JT; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Singaravelu R; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Public Health Agency of Canada, Ottawa, ON, Canada., Wang F; McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, ON, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada., Pelin A; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Tamming LA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Pugliese G; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Martin NT; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Crupi MJF; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Petryk J; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Austin B; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., He X; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Marius R; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Duong J; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Jones C; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Fekete EEF; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Alluqmani N; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Chen A; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Boulton S; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Huh MS; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Tang MY; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Taha Z; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Scut E; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Diallo JS; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Azad T; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Lichty BD; McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, ON, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada., Ilkow CS; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Bell JC; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Innovation Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jan 13; Vol. 13, pp. 1050250. Date of Electronic Publication: 2023 Jan 13 (Print Publication: 2022).

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Vanadyl sulfate-enhanced oncolytic virus immunotherapy mediates the antitumor immune response by upregulating the secretion of pro-inflammatory cytokines and chemokines.

Autor: Alluqmani N; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, ON, Canada.; Research Center, Molecular Oncology Department King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Jirovec A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, ON, Canada., Taha Z; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, ON, Canada., Varette O; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Chen A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Serrano D; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Maznyi G; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Khan S; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Forbes NE; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Arulanandam R; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Auer RC; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Surgery, University of Ottawa, Ottawa, ON, Canada., Diallo JS; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Nov 28; Vol. 13, pp. 1032356. Date of Electronic Publication: 2022 Nov 28 (Print Publication: 2022).

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Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer.

Autor: Crupi MJF; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Taha Z; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Janssen TJA; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Petryk J; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Boulton S; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Alluqmani N; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Jirovec A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Kassas O; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Khan ST; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Vallati S; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Lee E; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Huang BZ; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Huh M; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Pikor L; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., He X; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Marius R; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Austin B; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Duong J; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Pelin A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Neault S; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Azad T; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Breitbach CJ; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Stojdl DF; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Burgess MF; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., McComb S; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Auer R; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Diallo JS; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Ilkow CS; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Bell JC; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Nov 03; Vol. 13, pp. 1029269. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).

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Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen.

Autor: Taha Z; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Arulanandam R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Maznyi G; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Godbout E; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Carter-Timofte ME; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Kurmasheva N; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Reinert LS; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Chen A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Crupi MJF; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Boulton S; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Laroche G; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Phan A; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Rezaei R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Alluqmani N; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Jirovec A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Acal A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Fekete EEF; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Singaravelu R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Petryk J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Idorn M; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Potts KG; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Todesco H; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., John C; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Mahoney DJ; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Ilkow CS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Giguère P; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Alain T; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada., Côté M; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Paludan SR; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Olagnier D; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Bell JC; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Azad T; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Diallo JS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: jsdiallo@ohri.ca.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 Sep 07; Vol. 30 (9), pp. 2998-3016. Date of Electronic Publication: 2022 May 06.

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Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy.

Autor: Wong B; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6 Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Bergeron A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6 Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Alluqmani N; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6 Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Maznyi G; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6 Canada., Chen A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6 Canada., Arulanandam R; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6 Canada., Diallo JS; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6 Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Publikováno v: Molecular therapy oncolytics [Mol Ther Oncolytics] 2022 Apr 19; Vol. 25, pp. 146-159. Date of Electronic Publication: 2022 Apr 19 (Print Publication: 2022).

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Akademický článek

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy.

Autor: Wedge ME; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., Jennings VA; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Institute of Cancer Research, London, UK.; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Crupi MJF; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Poutou J; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Jamieson T; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Pelin A; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Pugliese G; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., de Souza CT; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Petryk J; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Laight BJ; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Boileau M; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Taha Z; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Alluqmani N; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., McKay HE; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Pikor L; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Khan ST; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Azad T; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Rezaei R; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Austin B; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., He X; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Mansfield D; Institute of Cancer Research, London, UK., Rose E; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Brown EEF; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Crawford N; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Alkayyal A; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Surendran A; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Singaravelu R; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Roy DG; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Migneco G; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., McSweeney B; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Cottee ML; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Jacobus EJ; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Oncology, University of Oxford, Oxford, UK., Keller BA; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Yamaguchi TN; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA., Boutros PC; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Geoffrion M; University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Rayner KJ; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Chatterjee A; The Ottawa Hospital, Division of Gastroenterology, Ottawa, Ontario, Canada., Auer RC; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada., Diallo JS; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Gibbings D; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., tenOever BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Melcher A; Institute of Cancer Research, London, UK., Bell JC; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Ilkow CS; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. cilkow@uottawa.ca.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada. cilkow@uottawa.ca.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 07; Vol. 13 (1), pp. 1898. Date of Electronic Publication: 2022 Apr 07.

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