Intrauterine position effects in a mouse model of maternal immune activation.

Autor: Schaer R; Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Mueller FS; Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Notter T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Weber-Stadlbauer U; Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Meyer U; Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland. Electronic address: urs.meyer@vetpharm.uzh.ch.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2024 Aug; Vol. 120, pp. 391-402. Date of Electronic Publication: 2024 Jun 17.

Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structures: A follow-up study in female mice.

Autor: von Arx AS; Institute of Veterinary Pharmacology and Toxicology, Vetsuisse, University of Zurich, Zurich, Switzerland., Dawson K; Institute of Veterinary Pharmacology and Toxicology, Vetsuisse, University of Zurich, Zurich, Switzerland., Lin HY; Institute of Veterinary Pharmacology and Toxicology, Vetsuisse, University of Zurich, Zurich, Switzerland., Mattei D; MSSM Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Notter T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Meyer U; Institute of Veterinary Pharmacology and Toxicology, Vetsuisse, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland. Electronic address: urs.meyer@vetpharm.uzh.ch., Schalbetter SM; Institute of Veterinary Pharmacology and Toxicology, Vetsuisse, University of Zurich, Zurich, Switzerland.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2023 Jul; Vol. 111, pp. 230-246. Date of Electronic Publication: 2023 Apr 24.

Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems.

Autor: Schalbetter SM; Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland., Mueller FS; Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland., Scarborough J; Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland., Richetto J; Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Weber-Stadlbauer U; Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland., Meyer U; Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Notter T; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, Wales, UK. nottert@cardiff.ac.uk.

Publikováno v: Lab animal [Lab Anim (NY)] 2021 Mar; Vol. 50 (3), pp. 69-75. Date of Electronic Publication: 2021 Feb 22.

Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.

Autor: Schalbetter SM; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland., von Arx AS; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland., Cruz-Ochoa N; Laboratory of Neural Connectivity, Faculties of Medicine and Natural Sciences, Brain Research Institute, University of Zürich, Zürich, Switzerland., Dawson K; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland., Ivanov A; Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitaetsmedizin, Berlin, Germany., Mueller FS; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland., Lin HY; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland., Amport R; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland., Mildenberger W; Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Mattei D; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Beule D; Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitaetsmedizin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Földy C; Laboratory of Neural Connectivity, Faculties of Medicine and Natural Sciences, Brain Research Institute, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zürich, Zürich, Switzerland., Greter M; Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Notter T; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland.; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, Wales, UK., Meyer U; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland.; Neuroscience Center Zürich, Zürich, Switzerland.

Publikováno v: Science advances [Sci Adv] 2022 Mar 04; Vol. 8 (9), pp. eabi6672. Date of Electronic Publication: 2022 Mar 02.

Brain microglia in psychiatric disorders

Autor: Mondelli, Valeria, Vernon, Anthony C, Turkheimer, Federico, Dazzan, Paola, Pariante, Carmine M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., et, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, Peferoen, LA, Vogel, DY, Ummenthum, K, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Steiner, J, Bielau, H, Brisch, R, Schnieder, TP, Trencevska, I, Rosoklija, G, Fillman, SG, Cloonan, N, Catts, VS, Rupprecht, R, Papadopoulos, V, Rammes, G, Qiu, ZK, Li, MS, He, JL, Hannestad, J, Gallezot, JD, Schafbauer, T, Israel, I, Ohsiek, A, Al-Momani, E, Mirzaei, N, Tang, SP, Ashworth, S, Gulyás, B, Makkai, B, Kása, P, Turkheimer, FE, Rizzo, G, Bloomfield, PS, Owen, DR, Yeo, AJ, DellaGioia, N, Setiawan, E, Wilson, AA, Su, L, Faluyi, YO, Hong, YT, Haarman, BC, Lek, RF Riemersma-Van der, Groot, JC de, Berckel, BN van, Bossong, MG, Boellaard, R, Doorduin, J, Vries, EF de, Willemsen, AT, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, Kenk, M, Selvanathan, T, Rao, N, Selvaraj, S, Veronese, M, Coughlin, JM, Wang, Y, Ambinder, EB, Doef, TF van der, Witte, LD de, Sutterland, AL, Hafizi, S, Tseng, HH, Holmes, SE, Hinz, R, Drake, RJ, Yaqub, M, Schuitemaker, A, Edison, P, Pavese, N, Lockhart, A, Davis, B, Matthews, JC, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, Cahn, W, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Brocklehurst, S, Miller, DH, Kubicki, M, Park, H, Westin, CF, Bouix, S, Dahlben, B, Oestreich, LK, Shenton, ME, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Ambler, A, Poulton, R, Caspi, A, Akhtar, R, Ciufolini, S, Meyer, U, So, PW, Lythgoe, DJ, Cotel, MC, Lenartowicz, EM, Anacker, C, Calcia, MA, Bonsall, DR, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F La, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Gschwind, T, Varga, B, Markó, K, Hádinger, N, Cattaneo, A, Ferrari, C, Uher, R, Belvederi, Murri M, Sandiego, CM, Pittman, B, Weber, MD, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Bard, F, Bhattacharya, A, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N

Publikováno v: Lancet psychiatry, 0(0), 587-597. Elsevier Limited
Mondelli, V, Vernon, A C, Turkheimer, F E, Dazzan, P & Pariante, C M 2017, ' Brain microglia in psychiatric disorders ', The Lancet Psychiatry, vol. 4, no. 7, pp. 563-572 . https://doi.org/10.1016/S2215-0366(17)30101-3
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SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming th

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https://research.vumc.nl/en/publications/07f168d1-2b4d-4483-b9b1-1659ff4e83f8