Attenuation of Lipopolysaccharide-Induced Inflammatory Responses through Inhibition of the NF-κB Pathway and the Increased NRF2 Level by a Flavonol-Enriched n -Butanol Fraction from Uvaria alba .

Autor: Notarte KIR; Laboratory of Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland21218, United States., Quimque MTJ; Laboratory of Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines.; Chemistry Department, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Tibanga, 9200Iligan City, Philippines., Macaranas IT; Faculty of Medicine and Surgery, University of Santo Tomas, España, 1008Manila, Philippines., Khan A; Department of Bioinformatics and Biostatistics, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dongchuan Road Shanghai, Minhang District, Shanghai200240, China., Pastrana AM; Faculty of Medicine and Surgery, University of Santo Tomas, España, 1008Manila, Philippines., Villaflores OB; Laboratory of Phytochemistry, Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines., Arturo HCP; Laboratory of Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines., Pilapil Iv DYH; Laboratory of Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines., Tan SMM; Laboratory of Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines., Wei DQ; Department of Bioinformatics and Biostatistics, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dongchuan Road Shanghai, Minhang District, Shanghai200240, China., Wenzel-Storjohann A; GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Product Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, 24106Kiel, Germany., Tasdemir D; GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Product Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, 24106Kiel, Germany.; Faculty of Mathematics and Natural Sciences, Kiel University, 24118Kiel, Germany., Yen CH; National Natural Product Libraries and High-Throughput Screening Core Facility, Kaohsiung Medical University, Kaohsiung80708, Taiwan., Ji SY; Department of Biochemistry, Dongeui University College of Korean Medicine, 52-57, Yangjeong-ro, Busanjin-gu, Busan47227Republic of Korea., Kim GY; Department of Marine Life Science, Jeju National University, 102 Jejudaehak-ro, Jeju-si, Jeju Special Self-Governing Province63243, Republic of Korea., Choi YH; Department of Biochemistry, Dongeui University College of Korean Medicine, 52-57, Yangjeong-ro, Busanjin-gu, Busan47227Republic of Korea., Macabeo APG; Laboratory of Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines.

Publikováno v: ACS omega [ACS Omega] 2023 Jan 31; Vol. 8 (6), pp. 5377-5392. Date of Electronic Publication: 2023 Jan 31 (Print Publication: 2023).

Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.

Autor: de Leon VNO; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines.; Department of Biological Sciences, College of Science, University of Santo Tomas, España Blvd., 1015, Manila, Philippines., Manzano JAH; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines.; Department of Biological Sciences, College of Science, University of Santo Tomas, España Blvd., 1015, Manila, Philippines., Pilapil DYH 4th; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines.; Department of Biological Sciences, College of Science, University of Santo Tomas, España Blvd., 1015, Manila, Philippines., Fernandez RAT; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines., Ching JKAR; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines.; Department of Chemistry, College of Science, University of Santo Tomas, España Blvd., 1015, Manila, Philippines., Quimque MTJ; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines.; The Graduate School, University of Santo Tomas, España Blvd., 1015, Manila, Philippines.; Chemistry Department, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Tibanga, 9200, Iligan City, Philippines., Agbay JCM; Chemistry Department, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Tibanga, 9200, Iligan City, Philippines.; Philippine Science High School - Central Mindanao Campus, 9217 Balo-I, Lanao del Norte, Philippines., Notarte KIR; Faculty of Medicine and Surgery, University of Santo Tomas, España Blvd., 1015, Manila, Philippines., Macabeo APG; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines. agmacabeo@ust.edu.ph.

Publikováno v: Journal, genetic engineering & biotechnology [J Genet Eng Biotechnol] 2021 Jul 16; Vol. 19 (1), pp. 104. Date of Electronic Publication: 2021 Jul 16.