De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.

Autor: Chen KE; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Guo Q; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Hill TA; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Cui Y; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia., Kendall AK; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA., Yang Z; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia., Hall RJ; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Healy MD; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Sacharz J; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia., Norwood SJ; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Fonseka S; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Xie B; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA., Reid RC; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Leneva N; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Parton RG; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.; Centre for Microscopy and Microanalysis, The University of Queensland, Queensland, Australia., Ghai R; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Stroud DA; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia.; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria 3052, Australia., Fairlie DP; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Suga H; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan., Jackson LP; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA., Teasdale RD; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia., Passioura T; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan.; Sydney Analytical, School of Life and Environmental Sciences and School of Chemistry, The University of Sydney, Camperdown, New South Wales 2050, Australia., Collins BM; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.

Publikováno v: Science advances [Sci Adv] 2021 Dec 03; Vol. 7 (49), pp. eabg4007. Date of Electronic Publication: 2021 Dec 01.

The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly.

Autor: Rehman A; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Hu SH; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Tnimov Z; Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Whitten AE; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., King GJ; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Jarrott RJ; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Norwood SJ; Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Alexandrov K; Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Collins BM; Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Christie MP; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Martin JL; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, QLD, Australia.

Publikováno v: PloS one [PLoS One] 2017 Aug 25; Vol. 12 (8), pp. e0183366. Date of Electronic Publication: 2017 Aug 25 (Print Publication: 2017).

Mammalian farnesyltransferase α subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)--dependent intracellular trafficking through recycling endosomes.

Autor: Kubala MH; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia., Norwood SJ; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia., Gomez GA; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia., Jones A; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia., Johnston W; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia., Yap AS; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia., Mureev S; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia., Alexandrov K; Institute for Molecular Bioscience, University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia. Electronic address: k.alexandrov@uq.edu.au.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2015 Dec 25; Vol. 468 (4), pp. 580-6. Date of Electronic Publication: 2015 Nov 10.

Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells.

Autor: Ghai R, Tello-Lafoz M, Norwood SJ, Yang Z, Clairfeuille T, Teasdale RD, Mérida I, Collins BM

Publikováno v: Journal of cell science [J Cell Sci] 2015 Feb 01; Vol. 128 (3), pp. 553-65.

Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.

Autor: Mas C; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Norwood SJ; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Bugarcic A; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Kinna G; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Leneva N; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Kovtun O; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Ghai R; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Ona Yanez LE; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Davis JL; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Teasdale RD; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia., Collins BM; From the Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia b.collins@imb.uq.edu.au.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2014 Oct 10; Vol. 289 (41), pp. 28554-68. Date of Electronic Publication: 2014 Aug 22.