Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Norton P Peet"'
Autor:
Adam Schafer, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E Ramirez, Norton P Peet, Michael Caffrey, Gregory R J Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009312 (2021)
Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that tor
Externí odkaz:
https://doaj.org/article/513584dcab26402ea212101359422d10
Autor:
Saad Alqarni, Laura Cooper, Jazmin Galvan Achi, Ryan Bott, Veeresh Kumar Sali, Andrew Brown, Bernard D. Santarsiero, Aleksej Krunic, Balaji Manicassamy, Norton P. Peet, Pin Zhang, Gregory R. J. Thatcher, Irina N. Gaisina, Lijun Rong, Terry W. Moore
Publikováno v:
Journal of Medicinal Chemistry. 65:14104-14120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2419fd8cb167e8defe6024cc591faf50
https://doi.org/10.1021/acs.jmedchem.2c01329
https://doi.org/10.1021/acs.jmedchem.2c01329
Autor:
Lijun Rong, Gregory R. J. Thatcher, Kevin Furlong, Norton P. Peet, Han Cheng, Ruikun Du, Balaji Manicassamy, Irina N. Gaisina, Qinghua Cui, Michael Caffrey, Ping Li
Publikováno v:
J Med Chem
Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9523f6963461e7f1d194489f6155c247
https://doi.org/10.1021/acs.jmedchem.9b01900
https://doi.org/10.1021/acs.jmedchem.9b01900
Autor:
Terry L. Bowlin, Donald T. Moir, Michelle M. Butler, James C. Burnett, Bing Li, Norton P. Peet
Publikováno v:
Molecules, Vol 16, Iss 1, Pp 202-220 (2010)
Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, le
Externí odkaz:
https://doaj.org/article/d719bdd325de4d4b8f36262565b81756
Autor:
Norton P. Peet, Adam Schafer, Lijun Rong, Julianna Han, Balaji Manicassamy, Han Cheng, Jasmine T. Perez
Publikováno v:
Curr Med Chem
Background: Influenza viruses cause severe upper respiratory illness in children and the elderly during seasonal epidemics. Influenza viruses from zoonotic reservoirs can also cause pandemics with significant loss of life in all age groups. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4a90ec787623f17465495928e7de3c
https://doi.org/10.2174/0929867324666170920165926
https://doi.org/10.2174/0929867324666170920165926
Publikováno v:
Molecular cancer therapeutics. 20(9)
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in humans. Over the past several decades, despite improvements in neurosurgical techniques, development of powerful chemotherapeutic agents, advances in rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c044125012203ad348fe8df45cd7952c
https://pubmed.ncbi.nlm.nih.gov/34172531
https://pubmed.ncbi.nlm.nih.gov/34172531
Autor:
Hyun Lee, Adam Schafer, Lijun Rong, Norton P. Peet, Yangfeng Li, Raghad Nowar, Rui Xiong, Erica Ollmann Saphire, Han Cheng, Michael Caffrey, Laura Cooper, Benjamin E. Ramirez, Gregory R. J. Thatcher
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009312 (2021)
PLoS Pathogens
PLoS Pathogens
Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that tor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e2e2dba33d62491007061fd573a91b
https://doaj.org/article/513584dcab26402ea212101359422d10
https://doaj.org/article/513584dcab26402ea212101359422d10
Autor:
Han Cheng, Lijun Rong, Norton P. Peet, Adam Schafer, Letitia Wong, Manu Anantpadma, Irina N. Gaisina, Robert A. Davey, Gregory R. J. Thatcher
Publikováno v:
J Med Chem
The recent Ebola epidemics in West Africa underscore the great need for effective and practical therapies for future Ebola virus outbreaks. We have discovered a new series of remarkably potent small molecule inhibitors of Ebola virus entry. These 4-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fec83c6d317babf7e714cf21796d988
https://pubmed.ncbi.nlm.nih.gov/32490678
https://pubmed.ncbi.nlm.nih.gov/32490678
Autor:
Eiman Mohammed AbdulRahman, Smanla Tundup, Norton P. Peet, Soheir Fathy Helal, Mervat Gaber El-Enany, Amira F.A. Hussein, Balaji Manicassamy, Jasmine T. Perez, Lijun Rong, Elizabeth Varhegyi, Aleksandar Antanasijevic, Han Cheng, Michael Caffrey
Publikováno v:
Antiviral Res
Influenza A viruses (IAVs) cause seasonal flu and occasionally pandemics. The current therapeutics against IAVs target two viral proteins - neuraminidase (NA) and M2 ion-channel protein. However, M2 ion channel inhibitors (amantadine and rimantadine)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ae436cc9f0bdfa7b9b549ac53861ff
https://europepmc.org/articles/PMC7243365/
https://europepmc.org/articles/PMC7243365/
Autor:
Veronica Soloveva, Dima N. Gharaibeh, Adam Schafer, Norton P. Peet, Cary Retterer, Tara Kenny, Rouzbeh Zamani, Lijun Rong, Han Cheng, Sina Bavari
Publikováno v:
Antiviral Research
Filoviruses, consisting of Ebola virus, Marburg virus and Cuevavirus, cause severe hemorrhagic fevers in humans with high mortality rates up to 90%. Currently, there is no approved vaccine or therapy available for the prevention and treatment of filo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f3d4e9e8ec9dfb90dbf235f2b665d8
https://doi.org/10.1016/j.antiviral.2017.06.015
https://doi.org/10.1016/j.antiviral.2017.06.015