Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Norris D. Flagler"'
Autor:
Mark J. Hoenerhoff, Keith R. Shockley, Ramesh C Kovi, Ronald Herbert, Raveena M Chhabria, Mamta Behl, Kevin Gerrish, Robert C. Sills, Arun R. Pandiri, Thai-Vu Ton, Teja N Peddada, Norris D Flagler
Publikováno v:
Arch Toxicol
Rodent alveolar/bronchiolar carcinomas (ABC) that arise either spontaneously or due to chemical exposure are similar to a subtype of lung adenocarcinomas in humans. B6C3F1/N mice and F344/NTac rats exposed to cobalt metal dust (CMD) by inhalation dev
Autor:
Julie F. Foley, Min Shi, Jingli Liu, Lindsay A Santiago, Lysandra Castro, Michael Staup, Linda Yu, Trey Saddler, Linda S. Birnbaum, William Xue, Alanna Burwell, Darlene Dixon, Norris D Flagler
Publikováno v:
Toxicol Res Appl
Toxicology Research and Application, Vol 5 (2021)
Toxicology Research and Application, Vol 5 (2021)
Tetrabromobisphenol A (TBBPA) is a brominated flame retardant that induces endometrial adenocarcinoma and other uterine tumors in Wistar Han rats; however, early molecular events or biomarkers of TBBPA exposure remain unknown. We investigated the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d289bf433bda9dad3e101b0e75bcded
https://europepmc.org/articles/PMC8774279/
https://europepmc.org/articles/PMC8774279/
Autor:
Natasha P. Clayton, Jingli Liu, Lysandra Castro, Linda Yu, Darlene Dixon, Norris D. Flagler, Stephen S. Li, Pierre R. Bushel, Erica Scappini, Yitang Yan
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Julie F. Foley, Sylvia C. Hewitt, Pawinee Piyachaturawat, Apichart Suksamrarn, Elizabeth Ney, Norris D. Flagler, Brianna Pockette, Wipawee Winuthayanon, Robnet T. Kerns, Pierre R. Bushel, Kenneth S. Korach
Publikováno v:
Environmental Health Perspectives
Background: Concerns regarding potential endocrine-disrupting chemicals (EDCs) have led to a need for methods to evaluate candidate estrogenic chemicals. Our previous evaluations of two such EDCs revealed a response similar to that of estradiol (E2)
Autor:
Xiaohua Gao, Michelle Klippel, Darlene Dixon, Alicia B. Moore, Yi Lu, Hoang-Long C. Huynh, Grace E. Kissling, Lysandra Castro, Norris D. Flagler, Linda Yu
Publikováno v:
Journal of Signal Transduction
Estrogen and growth factors play a major role in uterine leiomyoma (UtLM) growth possibly through interactions of receptor tyrosine kinases (RTKs) and estrogen receptor-alpha (ERα) signaling. We determined the genomic and nongenomic effects of 17β-
Autor:
Darlene Dixon, Linda Yu, Lysandra Castro, Charles J. Tucker, Norris D Flagler, Yitang Yan, Xiaohua Gao, Grace E. Kissling, Kyle Ham, Trevor K. Archer, Ray Dong
Publikováno v:
Cell Communication and Signaling : CCS
Background The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells. In this study, we evaluat
Autor:
Darlene Dixon, Elizabeth Ney, J. Mark Cline, Georgette D. Hill, Grace E. Kissling, Norris D. Flagler, Alicia B. Moore
Publikováno v:
Toxicologic Pathology. 39:508-515
Hormone replacement therapy and selective estrogen receptor modulators have been controversial treatment options for postmenopausal women because of their potential health benefits and/or risks. In this study, we determine the effects of the hormonal
Autor:
Berta Brodsky, Sheetal Trivedi, Uri Wormser, Shyamal D. Peddada, Norris D. Flagler, Abraham Nyska
Publikováno v:
Archives of Toxicology. 80:212-216
Sulfur mustard (SM) is powerful alkylator and highly cytotoxic blisterogen in both humans and animals. This study in male guinea pigs shows that, at an early stage (5 h) after SM exposure, a marked increase occurred in epithelial nuclear vacuolation,
Publikováno v:
Toxicology Methods. 7:123-136
The S-phase hepatocyte labeling index (LI) in rodents has been routinely evaluated by using the labeling agent 5-bromo-2' -deoxyuridine (BrdU) administered by surgically implanted osmotic minipumps or intraperitoneal injections. In this study, BrdU w
Autor:
Natasha P. Clayton, Jo Anne Johnson, Katsuhiko Yoshizawa, Norris D. Flagler, Grace E. Kissling, Abraham Nyska
Publikováno v:
Toxicologic Pathology. 33:1-3
Figure 1 presents the chemical names and structures of these 13 compounds. We summarize below the information concerning usages and effects in humans of these chemicals. Table 1 shows data from rats indicating the relationship between the severity of