Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Norrapat Shih"'
Autor:
Cho Yeow Koh, Norrapat Shih, Christina Y. C. Yip, Aaron Wei Liang Li, Weiming Chen, Fathiah S. Amran, Esther Jia En Leong, Janaki Krishnamoorthy Iyer, Grace Croft, Muhammad Ibrahim Bin Mazlan, Yen-Lin Chee, Eng-Soo Yap, Dougald M. Monroe, Maureane Hoffman, Richard C. Becker, Dominique P. V. de Kleijn, Vaishali Verma, Amita Gupta, Vijay K. Chaudhary, A. Mark Richards, R. Manjunatha Kini, Mark Y. Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used i
Externí odkaz:
https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1
Autor:
Maitreyee Sharma, Janaki Krishnamurthy Iyer, Norrapat Shih, Munmi Majumder, Venkata Satish Kumar Mattaparthi, Rupak Mukhopadhyay, Robin Doley
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153770 (2016)
In the present study a major protein has been purified from the venom of Indian Daboia russelii russelii using gel filtration, ion exchange and Rp-HPLC techniques. The purified protein, named daboxin P accounts for ~24% of the total protein of the cr
Externí odkaz:
https://doaj.org/article/447f876917154b33a21c4a97cf93a8d9
Autor:
Mark Y. Chan, Dougald M. Monroe, Norrapat Shih, Richard C. Becker, Aaron Wei Liang Li, Amita Gupta, R. Manjunatha Kini, Esther Jia En Leong, Eng Soo Yap, Janaki Krishnamoorthy Iyer, Vijay K. Chaudhary, Maureane Hoffman, Grace Croft, Yen-Lin Chee, Fathiah S Amran, Muhammad Ibrahim Bin Mazlan, Weiming Chen, A. Mark Richards, Dominique P.V. de Kleijn, Christina Yip, Cho Yeow Koh, Vaishali Verma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Despite their limitations, unfractionated heparin (UFH) and bivalirudin remain standard-of-care parenteral anticoagulants for percutaneous coronary intervention (PCI). We discovered novel direct thrombin inhibitors (DTIs) from tick salivary transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9318071bcc96f9e7dc232dcd0ce1b1fb
https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1
https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1
Autor:
Rajamani Lakshminarayanan, Norrapat Shih, Gavin S. Dawe, Subhi Marwari, Anders Poulsen, Brian W. Dymock, R. Manjunatha Kini, Charles W. Johannes
Publikováno v:
British Journal of Pharmacology
Background and purpose Depression and anxiety are common causes of disability, and innovative tools and potential pharmacological targets are actively sought for prevention and treatment. Therapeutic strategies targeting the relaxin-3 peptide or its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7876c9fbeb9e10bda86907bbcf1a91
https://doi.org/10.1111/bph.14774
https://doi.org/10.1111/bph.14774
Publikováno v:
Journal of Analytical and Applied Pyrolysis. 165:105547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da140c4f9828c27accbed3cc88bea2ce
https://doi.org/10.1016/j.jaap.2022.105547
https://doi.org/10.1016/j.jaap.2022.105547
Autor:
Cho Yeow Koh, Esther Jia En Leong, R M Kini, Norrapat Shih, F S Amran, Mark Y. Chan, Aaron Wei Liang Li
Publikováno v:
European Heart Journal. 40
Background We have isolated, variegin, a unique direct thrombin inhibitor (DTI) from tropical bont tick Amblyomma variegatum. Variegin inhibits thrombin active site and exosite-1 with an inhibitory constant of 0.3 nM (9-fold better than bivalirudin).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::443ccf221df04ee0687307cb73f3c005
https://doi.org/10.1093/eurheartj/ehz748.0135
https://doi.org/10.1093/eurheartj/ehz748.0135
Development of bioanalytical assays for variegin, a peptide-based bivalent direct thrombin inhibitor
Autor:
Yie Hou Lee, Norrapat Shih, Leonardo Pinto de Carvalho, Adriano Henrique Pereira Barbosa, José Marconi Almeida de Sousa, Antonio Carlos Camargo Carvalho, R. Manjunatha Kini, Mark Y. Chan, Mauricio Macario Rocha
Publikováno v:
Bioanalysis. 9(9)
Aim: Variegin is an anticoagulant peptide that will be tested in porcine models of percutaneous coronary intervention. We developed three bioanalytical assays for variegin quantitation and utilized these methods to evaluate pharmacokinetics of varieg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e054a56ad18d90b2c75400312b681c
https://pubmed.ncbi.nlm.nih.gov/28488882
https://pubmed.ncbi.nlm.nih.gov/28488882
Autor:
Rupak Mukhopadhyay, Robin Doley, Venkata Satish Kumar Mattaparthi, Munmi Majumder, Janaki Krishnamurthy Iyer, Norrapat Shih, Maitreyee Sharma
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0153770 (2016)
PLoS ONE, Vol 11, Iss 4, p e0153770 (2016)
In the present study a major protein has been purified from the venom of Indian Daboia russelii russelii using gel filtration, ion exchange and Rp-HPLC techniques. The purified protein, named daboxin P accounts for ~24% of the total protein of the cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235f8c5ddd7bd605b4cff69df59fb5b4
https://pubmed.ncbi.nlm.nih.gov/27089306
https://pubmed.ncbi.nlm.nih.gov/27089306