Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Normann Goodwin"'
Autor:
Greg M. Thurber, Normann Goodwin, Lorraine Thompson, James Legg, Thomas Sandal, Adnan O. Abu-Yousif, Thomas A. Keating, Qifeng Qiu, Anna Kopp, Steven Vance, Eshita Khera, Ian Nessler
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA-approved antibody–drug conjugates (ADC). However, a variety of pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb7ab2805dd13cdbb4ee95f79492b5
https://doi.org/10.1158/0008-5472.c.6511984.v1
https://doi.org/10.1158/0008-5472.c.6511984.v1
Autor:
Thomas Sandal, Ian Nessler, Steven Vance, Thomas A. Keating, Anna Kopp, Lorraine Thompson, Eshita Khera, Adnan O. Abu-Yousif, Qifeng Qiu, Greg M. Thurber, Normann Goodwin, James Legg
Publikováno v:
Cancer Research. 80:1268-1278
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA-approved antibody–drug conjugates (ADC). However, a variety of pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8f338667a5db5f2954b8cbbd436a79
https://doi.org/10.1158/0008-5472.can-19-2295
https://doi.org/10.1158/0008-5472.can-19-2295
Autor:
Thomas K. Berger, Christoph Brenker, Dagmar Wachten, U. Benjamin Kaupp, Timo Strünker, Normann Goodwin, Eberhard Krause, David M. Fußhöller, Astrid Müller, Nasim Dokani Khesroshahi, Wolfgang Bönigk
Publikováno v:
The Journal of Physiology. 595:1533-1546
Key points In human sperm, proton flux across the membrane is controlled by the voltage-gated proton channel Hv1. We show that sperm harbour both Hv1 and an N-terminally cleaved isoform termed Hv1Sper. The pH-control of Hv1Sper and Hv1 is distinctive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da9b7ee07c741fe605d9c9205f9da30
https://doi.org/10.1113/jp273189
https://doi.org/10.1113/jp273189
Autor:
Ian, Nessler, Eshita, Khera, Steven, Vance, Anna, Kopp, Qifeng, Qiu, Thomas A, Keating, Adnan O, Abu-Yousif, Thomas, Sandal, James, Legg, Lorraine, Thompson, Normann, Goodwin, Greg M, Thurber
Publikováno v:
Cancer Res
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA approved antibody-drug conjugates (ADCs). However, a variety of pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::841418c4a10f2dda8f4603f2f99fa0aa
https://pubmed.ncbi.nlm.nih.gov/31941698
https://pubmed.ncbi.nlm.nih.gov/31941698
Autor:
Emma L. Robinson, Anne Segonds-Pichon, Jonas Skogestad, Ioannis Smyrnias, David Oxley, Dagmar Wachten, Jan Magnus Aronsen, Normann Goodwin, Kateryna Demydenko, Martin D. Bootman, H. Llewelyn Roderick, Karin R. Sipido, Sakthivel Sadayappan
Publikováno v:
Journal of Molecular and Cellular Cardiology, 117, 1-18. ELSEVIER SCI LTD
The shortening of sarcomeres that co-ordinates the pump function of the heart is stimulated by electrically-mediated increases in [Ca]. This process of excitation-contraction coupling (ECC) is subject to modulation by neurohormonal mediators that tun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b51bea80335f23881775418a1a23db2
https://cris.maastrichtuniversity.nl/en/publications/9352f28b-b397-43a4-be02-91f4e85e1139
https://cris.maastrichtuniversity.nl/en/publications/9352f28b-b397-43a4-be02-91f4e85e1139
Autor:
U. Benjamin Kaupp, Christian Trötschel, Astrid Müller, Wolfgang Bönigk, Dmitry Fridman, Elisabeth Kremmer, Patric Pelzer, Timo Strünker, Normann Goodwin, Florian Windler, Jan F. Jikeli, Heiner Kuhl, Ansgar Poetsch, Bernd Timmermann, Melanie Flick, Nachiket D. Kashikar, Reinhard Seifert, Luis Alvarez
Publikováno v:
EMBO J. 34, 379-392 (2015)
The EMBO Journal
EMBO Journal
The EMBO Journal
EMBO Journal
Sperm guidance is controlled by chemical and physical cues. In many species, Ca(2+) bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca(2+) bursts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a181263b705f5d33f966ff218f58ad0
https://doi.org/10.15252/embj.201489376
https://doi.org/10.15252/embj.201489376
Autor:
Ulrich Benjamin Kaupp, Ingo Weyand, Nachiket D. Kashikar, Timo Strünker, Normann Goodwin, M. Krahling, M. Naruse, Astrid Müller, Christoph Brenker
Publikováno v:
The EMBO Journal. 31:1654-1665
The sperm-specific CatSper channel controls the intracellular Ca2+ concentration ([Ca2+]i) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins—female factors that stimulate Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ea6723b3211a00d988c6aa6ab067069
https://doi.org/10.1038/emboj.2012.30
https://doi.org/10.1038/emboj.2012.30
Autor:
Normann Goodwin, Jeannick Cizeau, Rachelle L. Dillon, Gregory P. Adams, Arjune Premsukh, Glen C. MacDonald, Shilpa Chooniedass, Bethan Archer, Lorraine Thompson
Publikováno v:
Cancer Research. 78:5770-5770
Targeted protein therapeutics or TPTs are single-protein therapeutics composed of targeting moieties genetically fused via peptide linker to cytotoxic protein payloads. TPTs are designed to overcome efficacy and safety challenges inherent within ADCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92512c04d44dbfb7d5cefbd71adf8f1f
https://doi.org/10.1158/1538-7445.am2018-5770
https://doi.org/10.1158/1538-7445.am2018-5770
Autor:
Timo Strünker, Normann Goodwin, Nachiket D. Kashikar, Reinhard Seifert, Magdalena Sznapka, U. Benjamin Kaupp
Publikováno v:
Biophysical Journal. 102(3)
In sea urchin sperm of Arbacia punctulata, a guanylyl cyclase (GC) serves as chemotaxis receptor that enables sperm to respond to a single molecule of the chemoattractant, resact. The efficiency of resact capture is high, because GC covers about 50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb947a6561d9804aa83ef73c21555e2
Autor:
Christoph, Brenker, Normann, Goodwin, Ingo, Weyand, Nachiket D, Kashikar, Masahiro, Naruse, Miriam, Krähling, Astrid, Müller, U Benjamin, Kaupp, Timo, Strünker
Publikováno v:
The EMBO journal. 31(7)
The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aab67006ab462871a9388d6cab800f97
https://pubmed.ncbi.nlm.nih.gov/22415366
https://pubmed.ncbi.nlm.nih.gov/22415366