Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Normand LeBlanc"'
Autor:
Ciara Viola, Thomas W Gould, Nicole Procacci, Normand Leblanc, Josette Zaklit, Gale L Craviso
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283736 (2023)
In studies exploring the potential for nanosecond duration electric pulses to serve as a novel modality for neuromodulation, we found that a 5 ns pulse triggers an immediate rise in [Ca2+]i in isolated bovine adrenal chromaffin cells. To facilitate o
Externí odkaz:
https://doaj.org/article/83214b1748a64e3cb85f01527a258079
Autor:
Tultul Saha, Joydeep Aoun, Paramita Sarkar, Andrea J. Bourdelais, Daniel G. Baden, Normand Leblanc, John M. Hamlyn, Owen M. Woodward, Kazi Mirajul Hoque
Publikováno v:
Pharmaceutical Biology, Vol 59, Iss 1, Pp 1008-1015 (2021)
Context Cucumber (Cucumis sativus Linn. [Cucurbitaceae]) is widely known for its purgative, antidiabetic, antioxidant, and anticancer therapeutic potential. However, its effect on gastrointestinal (GI) disease is unrecognised. Objective This study in
Externí odkaz:
https://doaj.org/article/4d4c56a7fd524cb48851e0eb97bd40fa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Exposing adrenal chromaffin cells to single 150 to 400 ns electric pulses triggers a rise in intracellular Ca2+ ([Ca2+]i) that is due to Ca2+ influx through voltage-gated Ca2+ channels (VGCC) and plasma membrane electropores. Immediate deliv
Externí odkaz:
https://doaj.org/article/33152d64968d4df4ab71a9e6c2b9f11b
Autor:
Tultul Saha, Joydeep Aoun, Mikio Hayashi, Sheikh Irshad Ali, Paramita Sarkar, Prasanta Kumar Bag, Normand Leblanc, Nadia Ameen, Owen M. Woodward, Kazi Mirajul Hoque
Publikováno v:
Biochemistry and Biophysics Reports, Vol 25, Iss , Pp 100912- (2021)
TMEM16A (Transmembrane protein 16A or Anoctamin1) is a calcium-activated chloride channel.(CaCC),that exerts critical roles in epithelial secretion. However, its localization, function, and regulation in intestinal chloride (Cl−) secretion remain o
Externí odkaz:
https://doaj.org/article/e21626b8bb1f4a1d99010739096d5722
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234114 (2020)
We previously reported that a single 5 ns high intensity electric pulse (NEP) caused an E-field-dependent decrease in peak inward voltage-gated Na+ current (INa) in isolated bovine adrenal chromaffin cells. This study explored the effects of a pair o
Externí odkaz:
https://doaj.org/article/f8fec88e0d274234b95da51cdb1b5d96
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181002 (2017)
This study examined the effect of 5 ns electric pulses on macroscopic ionic currents in whole-cell voltage-clamped adrenal chromaffin cells. Current-voltage (I-V) relationships first established that the early peak inward current was primarily compos
Externí odkaz:
https://doaj.org/article/85153b46c02d4f4782df4133acaaad78
Autor:
Nicole M. Procacci, Robert Louis Hastings, Aamir A. Aziz, Nina M. Christiansen, Jie Zhao, Claire DeAngeli, Normand LeBlanc, Lucia Notterpek, Gregorio Valdez, Thomas W. Gould
Publikováno v:
Glia. 71:926-944
Non-myelinating Schwann cells (NMSC) play important roles in peripheral nervous system formation and function. However, the molecular identity of these cells remains poorly defined. We provide evidence that Kir4.1, an inward-rectifying K+ channel enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297338af09bde886c0963cdf569b8e7a
https://doi.org/10.1002/glia.24315
https://doi.org/10.1002/glia.24315
Autor:
Jessica S. Reimche, Robert E. del Carlo, Edmund D. Brodie, Joel W. McGlothlin, Karen Schlauch, Michael E. Pfrender, Normand Leblanc, Chris R. Feldman
Publikováno v:
Molecular Ecology. 31:3827-3843
The repeated evolution of tetrodotoxin (TTX) resistance provides a model for testing hypotheses about the mechanisms of convergent evolution. This poison is broadly employed as a potent antipredator defence, blocking voltage-gated sodium channels (Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35482e05680ba4d5f4ad12bf9aaec50
https://doi.org/10.1111/mec.16538
https://doi.org/10.1111/mec.16538
Autor:
Normand Leblanc
Publikováno v:
Function. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da613029df50c7e3ae0613f13d0e829
https://doi.org/10.1093/function/zqad006
https://doi.org/10.1093/function/zqad006
Publikováno v:
Biophysical Journal
Cellular effects of nanosecond-pulsed electric field exposures can be attenuated by an electric field reversal, a phenomenon called bipolar pulse cancellation. Our investigations of this phenomenon in neuroendocrine adrenal chromaffin cells show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6743cf745f1fbb9bed0b9a23320ce888
https://doi.org/10.1016/j.bpj.2020.12.017
https://doi.org/10.1016/j.bpj.2020.12.017