Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Normand J. Cloutier"'
Autor:
Lei Zhao, Paul Whitehead, Lei Li, Mary Ellen Cvijic, Erica Cook, Akbar M. Siddiqui, Zhuyin Li, Darren Locke, Normand J. Cloutier, Dana E. Vanderwall, Youping Xiao, Larnie Myer, Holmes Derek A, Jia Peng, Richard W. Bishop, Shannon Hamilton
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
Quantitatively determining in vivo achievable drug concentrations in targeted organs of animal models and subsequent target engagement confirmation is a challenge to drug discovery and translation due to lack of bioassay technologies that can discrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9724a7b42ac240a9add9270f93ef94e
http://link.springer.com/article/10.1038/s41598-020-71347-6
http://link.springer.com/article/10.1038/s41598-020-71347-6
Autor:
Martyn Banks, Andrea D. Weston, Lisa Elkin, Jonathan O’Connell, Debra Nickischer, Normand J. Cloutier
Publikováno v:
Methods in Molecular Biology ISBN: 9781493973552
Within the Drug Discovery industry, there is a growing recognition of the value of high content screening (HCS), particularly as researchers aim to screen compounds and identify hits using more physiologically relevant in vitro cell-based assays. Ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2773afaf4e6bf70a4e60829b2e3d6bde
https://doi.org/10.1007/978-1-4939-7357-6_11
https://doi.org/10.1007/978-1-4939-7357-6_11
Autor:
Marga Spiller, Normand J. Cloutier, Randall B. Lauffer, Peter Caravan, Thomas J. Mcmurry, Jeffrey J. Ellison, Jaclyn M. Chasse, Claudio Luchinat, Giacomo Parigi, Sarah A. McDermid
Publikováno v:
Inorganic Chemistry. 46:6632-6639
The amphiphilic gadolinium complex MS-325 ((trisodium-{(2-(R)-[(4,4-diphenylcyclohexyl) phosphonooxymethyl] diethylenetriaminepentaacetato) (aquo)gadolinium(III)}) is a contrast agent for magnetic resonance angiography (MRA). MS-325 consists of two s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f61c279916d9ab9687d5fbb57cefac4
https://doi.org/10.1021/ic700686k
https://doi.org/10.1021/ic700686k
Autor:
Sarah A. McDermid, John C. Amedio, Matthew T. Greenfield, Arnold M. Raitsimring, Peter Caravan, Marga Spiller, Normand J. Cloutier, Randall B. Lauffer, Thomas J. McMurry, Stephen U. Dunham, Stephan G. Zech, Richard J. Looby
Publikováno v:
Chemistry - A European Journal. 11:5866-5874
The synthesis of a novel ligand, based on N-methyl-diethylenetriaminetetraacetate and containing a diphenylcyclohexyl serum albumin binding group (L1) is described and the coordination chemistry and biophysical properties of its Gd(III) complex Gd-L1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf30a66549f61dd180a265b82a46fe9
https://doi.org/10.1002/chem.200500338
https://doi.org/10.1002/chem.200500338
Autor:
Ronald M. Supkowski, William DeW. Horrocks, Richard J. Looby, Thomas J. McMurry, Randall B. Lauffer, Jeff W.M. Bulte, John C. Amedio, Sarah A. McDermid, Normand J. Cloutier, Matthew T. Greenfield, Peter Caravan, Stephen U. Dunham
Publikováno v:
Journal of the American Chemical Society. 124:3152-3162
MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to human serum albumin (HSA) in plasma. Binding to HSA serves to prolong plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ada0ace5b3191a314e80bf237e2b9a9
https://doi.org/10.1021/ja017168k
https://doi.org/10.1021/ja017168k
Autor:
Dandan Zhao, Alexander Zelensky, Qi Guo, Yingjie Zhu, Richard Shaginaw, Judith Wardwell-Swanson, Mahesh Nawade, Donald G. Jackson, Mohammad Shaikh, Michele Agler, Myles Fennell, Normand J. Cloutier, Michael Lenard, James V. Scharpf, Christopher P. Miller, James Gill
Publikováno v:
Journal of biomolecular screening. 15(7)
The effective analysis and interpretation of high-content screening (HCS) data requires joining results to information on experimental treatments and controls, normalizing data, and selecting hits or fitting concentration-response curves. HCS data ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f0353e86b85d6805436a01355efe75
https://pubmed.ncbi.nlm.nih.gov/20639503
https://pubmed.ncbi.nlm.nih.gov/20639503
Publikováno v:
Plant Cell Reports. 11:86-89
When cell suspension cultures of Catharanthus roseus are treated with autoclaved elicitor from the fungus Pythium aphanidermatum, they respond with the rapid transient induction of tryptophan decarboxylase (TDC) and strictosidine synthase (SS) enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffaef618a89b9ddf076996d62c18d7f3
https://doi.org/10.1007/bf00235259
https://doi.org/10.1007/bf00235259
Autor:
Christian D. Ferrante, Moneesh Chatterjee, Lynda S. Cook, John E. Leet, Elizabeth A. Dumas, Martyn Banks, David A. Stock, John G. Houston, Normand J. Cloutier, Meredith Ferrante, William E. Monahan, Sandra L. Matson, John Watson
Publikováno v:
Journal of biomolecular screening. 14(5)
Preserving the integrity of the compound collection and providing high-quality materials for drug discovery in an efficient and cost-effective manner are 2 major challenges faced by compound management (CM) at Bristol-Myers Squibb (BMS). The demands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c928e07608d74d2a3abca533a60fdd59
https://pubmed.ncbi.nlm.nih.gov/19483144
https://pubmed.ncbi.nlm.nih.gov/19483144
Isotopic labeling of RNA with 13C and 15N has become a routine procedure in structural studies by NMR spectroscopy. The methodology in this paper describes the random fractional deuteration of RNA using the obligate methylotropic bacterium, Methyloph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5eaf3445cb5be20dcd0507e7ec4fe8
https://europepmc.org/articles/PMC146305/
https://europepmc.org/articles/PMC146305/
Autor:
Atsushi Nagahisa, Normand J. Cloutier, Stephen R. Wilson, Emily Miao, Chunsong Zuo, William H. Orme-Johnson, Subhendu Joardar, Chang Yon Byon
Publikováno v:
Biochemistry. 34(26)
(20S)-22-thiacholesterol (1) is found to be a potent competitive inhibitor of pregnenolone biosynthesis from cholesterol by purified reconstituted bovine adrenal cytochrome P-450scc. The apparent dissociation constant Kd, determined from difference s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f81cde592643f4abf5d7d02a9147570
https://pubmed.ncbi.nlm.nih.gov/7599132
https://pubmed.ncbi.nlm.nih.gov/7599132